Abstract
Hydroxypropyl cyclodextrins are one of the most freely soluble cyclodextrin derivatives. These cyclodextrins have been found very useful in parenteral preparations [1] and in solid dosage forms [2] because of their non-toxic nature, complete and rapid dissolution in water. Hydroxypropyl gamma cyclodextrin can effectively encapsulate a number of bulky drug molecules due to its large cavity diameter. Tolbutamide is a poorly water-soluble hypoglycaemic agent; it forms inclusion compounds with b-cyclodextrin [3,4] and hydroxypropyl b-cyclodextrin [5]. In this paper attempt has been made to know if the solubility and dissolution of this drug become affected due to the presence of hydroxypropyl gamma cyclodextrin both in kneaded systems and in physical mixtures.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brewster, M.E., Simpkins, J.W., Hora, M.S., Stern, W.C. and Bodor, N. J. (1998) The potential uase of cyclodextrin in parenteral formulations. Parenteral Sci. Technol. 43, 231–240.
Pitha, J., Harman, S.M. and Michel, M.E. (1986) Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones. J.Pharm.Sci. 75, 165–167.
Gandhi, R.B. and Karara, A.H. (1988) Characterisation, dissolution and diffusion properties of tolbutamide-ß-cyclodextrin complex system. Drug Dev. Ind. Pharm. 14, 657–682.
Veiga, F., Teixeira-Dias, J.J.C., Kedzierewicz, F., Sousa, A. and Maincent, P. (1996) Inclusion complexation of tolbutamide with ß-cyclodextrin and hydroxypropyl ß-cyclodextrin. Int. J. Pharm. 129, 63–71.
Veiga, M.D. and Ahsan, F. (1998) Solubility study of tolbutamide in monocomponent and dicomponent solution of water. Int.J. of Pharm. 160, 143–149.
Higuchi, T. and Connors, A. (1965) Phase solubility techniques, in Reilly, C. (ed.) Advances in Analytical Chemistry and Instrumentation, Wiley Interscience Publishers, New York, pp. 117–212.
Rajewski, R.A. and Stella, V.J (1996) Pharmaceutical applications of cyclodextrin. 2. In vivo drug delivery. J. Pharm. Sci. 85, 1142–1169.
Thompson, D.O. (1997) Cyclodextrins—enabling excipients: Their present and future use in pharmaceuticals CRC Cht. Rev. Ther. Drug Carrier Syst. 14, 1–104.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Veiga, MD., Ahsan, F. (1999). Hydroxypropyl Gamma Cyclodextrin as a Solubiliser and Dissolution Enhancing Agent: The Case of Tolbutamide—A Poorly Water-Soluble Drug. In: Labandeira, J.J.T., Vila-Jato, J.L. (eds) Proceedings of the Ninth International Symposium on Cyclodextrins. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4681-4_75
Download citation
DOI: https://doi.org/10.1007/978-94-011-4681-4_75
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5971-8
Online ISBN: 978-94-011-4681-4
eBook Packages: Springer Book Archive