Abstract
In recent years, complex interactions between the nervous, the endocrine and the immune system have been thoroughly investigated resulting in a large database of knowledge. On the other hand, the effectiveness of electromagnetic stimulation of the neurons has also been widely demonstrated, and the techniques of such stimulation are well established. A combination of the two knowledges offers a possibility to artificially influence the nervous - endocrine - immune (NEI) interactions, in cases when the immunity of a person is impaired, or its glandular functions are disordered. There is a wealth of reports on the use of electromagnetic fields to treat various pathological conditions. The number of diagnostic procedures that rely on the use of electromagnetic fields is also increasing. Therapeutic and diagnostic approaches include: surgical knife, cancer treatment (both hyperthermia and sub-hyperthermal EMF treatment, alone or in combination with other antitumor treatments), chronic and acute wound healing, bone healing, magnetic resonance imaging and spectroscopy, catheter ablation for cardiac arrhythmia, pain treatment, thermotherapy of musculo-skeletal tissue in physical medicine and rehabilitation, edema treatment, etc [1–5]. A number of these therapeutic procedures rely on excessive local heating of the tissue by means of radio frequency electromagnetic field. Other therapeutic procedures however do not have fully established mechanisms of EMFs. It is also very interesting that various signals in terms of amplitudes, pulse shape and frequencies are successfully used. At the moment a large database of EMF interactions with biological systems on various levels are available. Yet, due to very complex interactions between different levels, it is difficult if not impossible to explain reported therapeutic effects. Additional problem is that dosimetric determinations are only available in electrosurgery, catheter ablation, cancer hyperthermia and MR imaging and spectroscopy.
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References
Pakhomov, A.G. et al. (1998) Current state and implications of research on biological effects of millimeter waves: A review of the literature, Bioelectromagnetics 19, 393–413.
Elson, E. (1995) Biologic effects of radio frequency and microwave fields: In vivo and in vitro experimental results, in J.D. Bronzino (ed.), The Biomedical Engineering Handbook, CRC Press, Boca Raton, pp.1417–1423.
Chou, C.K. (1995) Radiofrequency hyperthermia in cancer therapy, in J.D. Bronzino (ed.), The Biomedical Engineering Handbook, CRC Press, Boca Raton, pp.1424–1430.
Consensus conference on use of electrical and magnetic stimulation in orthopedics and traumatology, Giornale Italiano di Ortopedia e Traumatologia (in press).
Pilla, A.A. et al. (1996) Effect of pulsed radio frequency therapy on edema from grades I and II ankle sprains: a placebo controlled, randomized, multi-site double blind clinical study, J. Athl. Training 31, 53.
Chadwick, D. J. and Marsh, J. (1992) Functional Anatomy of the Hypothalamus,John Wiley & Sons, New York.
Sabharwal, P. et al. (1992) Prolactin synthesized and secreted by human peripheral blood mononuclear cells: An autocrine growth factor for lymphoproliferation, Proc. Natl. Acad. Sci. USA 89, 7713–7716.
Cunningham, E.T.Jr. and De Souza, E.B. (1993) Interleukin 1 receptors in the brain and endocrine tissues, Immunol. Today 14, 171–176.
Krueger, J.M. and Majde, J.A. (1994) Microbial products and cytokines in sleep and fever regulation, Crit. Rev. Immunol. 14, 355–362.
Vodovnik, L. and Karba, R. (1992) Treatment of chronic wounds by means of electric and electromagnetic fields. Part 1: Literature review, Med. Biol. Eng. Comput. 30, 257–266.
Miklavcic, D. et al. (1997) Host’s immune response in electrotherapy of murine tumors by direct current, Eur. Cytokine Netw. 8, 275–279.
Grosse, C. and Schwan, H.P. (1992) Cellular membrane potentials induced by alternating fields, Biophys. J. 63, 1632–1642.
Komik, T., Miklavcic, D., and Slivnik, T. (1998) Time course of transmembrane voltage induced by time-varying electric fields - a method for theoretical analysis and its application. Bioelectrochem. Bioenerg. 45, 3–16.
Fear, E.C. and Stuchly, M.A. (1998) Biological cells with gap junctions in low frequency electric fields, IEEE Trans. Biomed. Eng. 45, 856–866.
Spadaro, J.A. (1997) Mechanical and electrical interactions in bone remodelling, Bioelectromagnetics 18, 193–202.
Sorrentino, V. (1989) Growth factors, growth inhibitors and cell cycle control - A review, Anticancer Res. 9, 1925–1936.
Chandy, K.G. et al. (1985) Electroinimmunology: The physiologic role of ion channels in the immune system, J. Immunol. 135, 787–791.
Illis, L.S., Sedgwick, E.M., and Tallis, R.C. (1980) Spinal cord stimulation in multiple sclerosis: Clinical results, J. Neurol. Neurosurg. Psych. 43, 1–14.
Kaada, B. (1983) Promoted healing of chronic ulceration by transcutaneous nerve stimulation (TNS), VASA J. Vascular. Dis. 12, 262–269.
Sabbioni, M.E.E. (1993) Psychoneuroimmunological issues in psycho-oncology, Cancer Invest. 11, 440–450.
Husband, A.J. (1993) Role of central nervous system and behaviour in the immune response, Vaccine 11, 805–814.
Old, L.J. (1988) Tumor necrosis factor, Sci. Am. 258(3), 41–49.
Chambers, D.A., Cohen, R.L., and Perlman, R.L. (1993) Neuroimmune modulation: Signal transduction and catecholamines, Neurochem. Int. 22, 95–100.
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Miklavčič, D., Vodovnik, L., Kotnik, T. (2000). Possible Effects of Electromagnetic Fields on the Nervous — Endocrine — Immune Interactions. In: Klauenberg, B.J., Miklavčič, D. (eds) Radio Frequency Radiation Dosimetry and Its Relationship to the Biological Effects of Electromagnetic Fields. NATO Science Series, vol 82. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4191-8_53
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DOI: https://doi.org/10.1007/978-94-011-4191-8_53
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