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Function and Dysfunction of the Sinus Node: Clinical Studies in the Evaluation of Sinus Node Function

  • Chapter
The Sinus Node

Abstract

The sick sinus syndrome is a descriptive term coined by Lown (1966) and popularized by Ferrer (1968), referring to a constellation of clinical signs, symptoms, and electrocardio-graphic (ECG) criteria defining sinus node dysfunction. The syndrome is characterized by syncope or other manifestations of cerebral dysfunction in association with sinus brady-cardia, sinus arrest, sinoatrial block, alternating bradyarrhythmias and tachyarrhythmias and/or carotid hypersensitivity. Clinical signs and symptoms, however, result from failure of escape pacemaker function not from sinus node malfunction per se (Mandel and Laks, 1974); thus, the sick sinus syndrome may represent a generalized disorder of the conduc- tion system.

This work was supported in part by NIH Grant no. 17651.

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References

  • Abbott, J.P., Kunkel, F., Hirschfeld, D.S., Scheinman, M.M.: Effects of cardiac pacing and heart rate acceleration on exercise-induced symptoms in patients with sick sinus syndrome. Circulation 49 and 50: 111–119, 1974

    Google Scholar 

  • Amory, D.W., West, T.C.: Chronotropic response following direct electrical stimulation of the isolated sinoatrial node: A pharmacological evaluation. J Pharmacol Exptl Therap 137; 14, 1962

    CAS  Google Scholar 

  • Arguss, N.S., Rosin, E.Y., Adolph, A.J., Fowler, NO.: Significance of chronic sinus bradycardia in elderly people. Circulation 46: 924, 1972

    Google Scholar 

  • Balke, B., Ware, R.W.: An experimental study of physical fitness of air force personnel. US. Armed Forces MedJ lO: 675, 1959

    Google Scholar 

  • Barks, J.B., Bosman, C.K., Cochrane, J.W.C.: Congenital cardiac arrhythmias. Lancet 2: 531, 1964

    Google Scholar 

  • Bashour, T., Hemb, R., Wickramesekaran, R., Strauss, H.C., Bigger, J.T., Jr.: An unusual effect of atropine on overdrive suppression. Circulation 48: 911, 1973

    PubMed  CAS  Google Scholar 

  • Beiser, G.D., Epstein, S.E., Stampfer, M., Goldstein, R.E.: Impaired heart rate response to sympathetic nerve stimulation in patients with cardiac decompensation. Circulation 38: VI–40, 1968

    Google Scholar 

  • Bigger, J.T.: A simple, rapid method for the diagnosis of first-degree sinoatrial block in man. Am Heart J 87: 731, 1974

    Article  PubMed  Google Scholar 

  • Bigger, J.T.: The sick sinus syndrome. Prac Cardiol 3: 66, 1977

    Google Scholar 

  • Bond, R.C., Engel, T.R., Schaal, S.F.: Effect of digitalis on sinoatrial conduction in man (abstract). Am J Cardiol 33: 128, 1974

    Article  Google Scholar 

  • Bonke, F.I.M., Bouman, L.N., Van Rijn H.E.: Change of cardiac rhythm in the rabbit after an atrial premature beat. Circ Res 24: 533, 1969

    PubMed  CAS  Google Scholar 

  • Bonke, F.I.M., Bouman, L.N., Schopman, F.J.G.: Effect of an early atrial premature beat on activity of the sinoatrial node and atrial rhythm in the rabbit. Circ Res 24: 704, 1971

    Google Scholar 

  • Brasil, A.: Autonomic sinoatrial block. A new disturbance of the heart mechanism. Arquivos Brasileiras de Cardiologia 8: 159, 1955

    CAS  Google Scholar 

  • Breithardt, G., Seipel, L.: The effect of premature atrial depolarization on sinus node automaticity in man. Circulation 53: 920, 1976

    PubMed  CAS  Google Scholar 

  • Breithardt, G., Seipel, L., Both, A., Loogen, F.: The effect of atropine ofcalculated sinoatrial conduction time in man. Eur J Cardiol 4: 49, 1976

    PubMed  CAS  Google Scholar 

  • Breithardt, G., Seipel, L., Loogen, F.: Sinus node recovery time and calculated sinoatrial conduction time in normal subjects and patients with sinus node dysfunction. Circulation 56: 43, 1977

    PubMed  CAS  Google Scholar 

  • Brooks, C./McC., Lu, H.-H.: The sinoatrial pacemaker of the heart. Charles C. Thomas, Publishing Co., Springfield, Illinois, p. 109–110, 1972

    Google Scholar 

  • Chadda, K.D., Banke, V.S., Bodenheimer, M.M., Helfant, R.H.: Corrected sinus node recovery time: Experimental, physiological and pathologic determinents. Circulation 51: 797, 1975

    PubMed  CAS  Google Scholar 

  • Childers, R.W., Arnsdorf, M.F., de la Fuente, D.J., Gambetta, M., Svenson, R.: Sinus node echoes. Am J Cardiol 31: 220, 1973

    Article  PubMed  CAS  Google Scholar 

  • Cohen, A.E., Lewis, T.: Auricular fibrillation and complete heart block: A description of a case of Adams-Stokes syndrome including the postmortem examination. Heart 4: 15, 1912

    Google Scholar 

  • Cohn, A.E., Lewis, T.: Auricular fibrillation and complete heart block. A description of a case of Adams-Stokes syndrome including the postmortem examination. Heart 4: 15, 1913

    Google Scholar 

  • Conde, C., Leppo, J., Lipski, J., Stimmel, B., Litwak, R., Donoso, E., Dack, S.: Effectiveness of pacemaker treatment in the bradycardiatachycardia syndrome. Am J Cardiol 32: 209, 1973

    Article  PubMed  CAS  Google Scholar 

  • Corday, E., Bazika, V., Lang, T.W., Pappelbaum, S., Gold, H., Berstein, H.: Detection of phantom arrhythmias and evanescent ECG abnormalities. JAMA 193: 417, 1965

    PubMed  CAS  Google Scholar 

  • Covell, J.W., Chidsey, C.A., Braunwald, E.: Reduction of the cardiac responses to postganglionic sympathetic nerve stimulation in patients with cardiac decompensation. Circ Res 19: 51, 1966

    Google Scholar 

  • Crook, B.R.M., Cashman, P.M.M., Stott, F.D., Raftery, E.B.: Tape monitoring of the electrocardiogram in ambulant patients with sinoatrial disease. Br Heart J 35: 1009, 1973

    Article  PubMed  CAS  Google Scholar 

  • Dauchat, P., Gravenstein, J.S.: Effects of atropine on the electrocardiogram in different age groups. Clin Pharmacol Therap 12: 274, 1974

    Google Scholar 

  • Davies, M.J., Pomerance, A.: Quantitative study of aging changes in the human sinoatrial node and internodal tracts. Br Heart J 34: 150, 1972

    Article  PubMed  CAS  Google Scholar 

  • Denes, P., Delon, W., Dhingra, R.: The effects of cycle length on cardiac refractory periods in man. Circulation 49: 32, 1974

    PubMed  CAS  Google Scholar 

  • Dhingra, R.C., Wyndham, C., Amat-y-Leon, F., Denes, P., Wu, D., Rosen, K.M.: Sinus nodal responses to atrial extra-stimuli in patients without apparent sinus node disease. Am J Cardiol 36: 445, l975a

    Article  Google Scholar 

  • Dhingra, R.C., Amat-y-Leon, F., Wyndam, C., Denes, P., Wu, D, Pouget, J.M., Rosen, K.M.: Electrophysiologic effects of atropine on human sinus node and atrium. Am J Cardiol 38: 429, 1976a

    Article  PubMed  CAS  Google Scholar 

  • Dhingra, R.C., Amat-y-Leon, F., Wyndham, C., Wu, D., Denes, P., Rosen, K.M.: The electrophysiological effects of ouabain on sinus node and atrium in man. J Clin Invest, 56: 555, l975b

    Article  Google Scholar 

  • Dhingra, R.C., Amat-y-Leon, F., Wyndham, C., Denes, P., Wu, D., Miller, R.H., Rosen, K.M.: Electrophysiologic effects of atropine on sinus node and atrium in patients with sinus node dysfunction. Am J Cardiol 38: 848, 1976b

    Article  PubMed  CAS  Google Scholar 

  • Dhingra, R.C., Amat-y-Leon, F., Wyndham, C., Deedwania, P.C., Wu, D., Denes, P., Rosen, K.: Clinical significance of prolonged sinoatrial conduction time. Circulation 55: 8, 1977

    PubMed  CAS  Google Scholar 

  • Dighton, D.H.: Sinus bradycardia: Autonomic influences and clinical assessment. Br Heart J 36: 791, 1974

    Article  PubMed  CAS  Google Scholar 

  • Dighton, D.H.: Sinoatrial block: Autonomic influences and clinical assessment. Br Heart J 37: 321, 1975

    Article  PubMed  CAS  Google Scholar 

  • Eckberg, D.L., Drabinsky, M., Braunwald, E.: Defective cardiac parasympathetic control in patients with heart disease. New Engl J Med 285: 877, 1971

    Article  PubMed  CAS  Google Scholar 

  • Ellestad M.H.: Stress testing: Principles and practice. F.A. Davis, Publishing Co., Philadelphia Penn., p. 38, 1975

    Google Scholar 

  • Engel, T.R., Schaal, S.F.: Digitalis in the sick sinus syndrome: The effects of digitalis on sinoatrial automaticity and atrioventricular conduction. Circulation 48: 1201, 1973

    PubMed  CAS  Google Scholar 

  • Engel, T.R., Meister, S.G., Feitosa, G.S., Fisher H.A., Franki, W.S.: Appraisal of sinus node artery disease. Circulation 52: 286, 1975

    PubMed  CAS  Google Scholar 

  • Engel, T.R., Bond, R.C., Schaal, S.F.: First-degree sinoatrial heart block: Sinoatrial block in the sick sinus syndrome. Am Heart J 91: 303, 1976

    Article  PubMed  CAS  Google Scholar 

  • Ferrer, M.I.: The sick sinus syndrome in atrial disease. JAMA 206: 645, 1968

    Article  PubMed  CAS  Google Scholar 

  • Fisch, C., Greenspan, K., Knobel, SB., Feigenbaum, H.: Effect of digitalis on conduction of the heart. Frog Cardiovasc Dis 6: 343, 1964

    Article  CAS  Google Scholar 

  • Furchgott, R.F., Dc Gubaroff, T., Grossman, A.: Release of autonomic mediators in cardiac tissue by suprathreshold stimulation. Science 129: 328, 1959

    Article  PubMed  CAS  Google Scholar 

  • Fraser, G.R., Froggatt, P., James, TN.: Congenital deafness associated with electrocardiographic abnormalities, fainting attacks and sudden death: A recessive syndrome. Quart J Med 33: 361, 1964

    PubMed  CAS  Google Scholar 

  • George, C.F., Conolly, M.E., Briant, F., Dollery, C.T.: Intravenously administered isoproterenol sulfate: Dose-response curves in man. Arch Int Med 30: 361, 1972

    Article  Google Scholar 

  • Goldberg, A.N., Moran, J.F., Resnekov, L.: Multistage electrocardiographic tests. Am J Cardiol 26: 84, 1970

    Article  Google Scholar 

  • Goldreyer, B.N., Damato, AN.: Sinoatrial node entrance block. Circulation 44: 789, 1971

    PubMed  CAS  Google Scholar 

  • Goldstein, R.E., Beiser, D.G., Stampfer, M., Epstein, S.E.: Impairment of autonomically mediated heart rate control in patients with cardiac dysfunction. Circ Res 36: 571, 1975

    PubMed  CAS  Google Scholar 

  • Goodman, D.J., Rosen, R.M., Ingham, R., Rider, A.K., Harrison, D.C.: Sinus node function in the deverated human heart. Effect of digitalis. Br Heart J 37: 612, 1975

    Article  PubMed  CAS  Google Scholar 

  • Gupta, P.K., Lichstein, E., Chadda, K.D., Baduri, E.: Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. Am J Cardiol 34: 265, 1974

    Article  PubMed  CAS  Google Scholar 

  • Hamlin, R.L., Smith, C.R., Smetzer, D.L.: Sinus arrhythmia in the dog. Am J Physiol 210: 321, 1966

    PubMed  CAS  Google Scholar 

  • Han, J.H., Malozzi, A.M., Moe, G.K.: Sino-atrial reciprocation in the isolated rabbit heart. Circ Res 22: 355, 1968

    PubMed  CAS  Google Scholar 

  • Hartel, G., Talvensaari, T.: Treatment of sinoatrial syndrome with permanent cardiac pacing in 90 patients. Acta Med Scan 198: 341, 1975

    Article  CAS  Google Scholar 

  • Hirschfeld, D.S., Peters, R., Kunkel, F., Scheinman, M.M.: Sinoatrial conduction time (SACT) and abnormal perinodal refractoriness in patients with sinus node disease (SND). Circulation 52: II–112, 1975

    Google Scholar 

  • Hoffman, B.F., Cranefield, P.F.: Electrophysiology of the heart. New York, McGraw-Hill, 1960

    Google Scholar 

  • Hoffman, B.F., Singer D.H.: Effects of digitalis on electrical activity of cardiac fibers. Frog Cardiovasc Dis 7: 226, 1964

    Article  CAS  Google Scholar 

  • Holden, W., McAnullty, J., Rahimtoola, S.: Inadequate heart rate response to exercise in the sick sinus syndrome. Circulation 53 and 54: II–146, 1976

    Google Scholar 

  • James, T.N.: Myocardial infarction and atrial arrhythmias. Circulation 24: 761, 1961

    PubMed  CAS  Google Scholar 

  • Jordan, J.L., Yamaguchi, I., Mandel, W.J.: The sick sinus syndrome: Pathophysiology, significance and treatment. Cardiol Dig 12: 11, 1977a

    Google Scholar 

  • Jordan, J., Yamaguchi, I., Mandel, W.J., McCullen, A.E.: Comparative effects of overdrive on sinus and subsidiary pacemaker function. Am Heart J 93: 367, 1977b

    Article  PubMed  CAS  Google Scholar 

  • Jordan, J.L., Yamaguchi, I., Mandel, W.J.: Characteristics of sinoatrial conduction in patients with coronary artery disease. Circulation 55: 569, 1977c

    PubMed  CAS  Google Scholar 

  • Jordan, J.L., Yamaguchi, I., Mandel, W.J.: Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome. Circulation, 1977d (in press)

    Google Scholar 

  • Jose, A.D., Collison, D.: The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res 4: 160, 1970

    Article  PubMed  CAS  Google Scholar 

  • Kaplin, B.M., Langendorf, R., Lev, M., Pick, A.: Tachycardiabradycardia syndrome (so-called “sick sinus syndrome”). Pathology, mechanisms and treatment. Am J Cardiol 31: 497, 1973

    Article  Google Scholar 

  • Klein, H.O., Singer, D.H., Hoffman, B.F.: Effects of atrial premature systoles on sinus rhythm in the rabbit. Circ Res 32: 480, 1973

    PubMed  CAS  Google Scholar 

  • Konisai, T.: Electrophysiologic consideration on sick sinus syndrome. Japan Circ J 40: 194, 1976

    Article  Google Scholar 

  • Kulbertus, H.E., Leval-Rutten, F. de, Demoulin, J.C.: Sino-atrial disease: A report on 13 cases. J Electrocardiol 6: 303, 1973

    Article  PubMed  CAS  Google Scholar 

  • Kulbertus, H.E., Leval-Rutten, F. de, Mary, L., Casters, P.: Sinus node recovery time in the elderly. Br Heart J 37: 420, 1975

    Article  PubMed  CAS  Google Scholar 

  • Lange, G.: Action of driving stimuli from intrinsic and extrinsic sources on in situ cardiac pacemaker tissues. Circ Res 17: 449, 1965

    PubMed  CAS  Google Scholar 

  • Langendorf, R., Lesser, M.E., Plotkin, P., Levin, B.D.: Atrial parasystole with interpolation: Observations on prolonged sinoatrial conduction. Am Heart J 63: 649, 1962

    Article  PubMed  CAS  Google Scholar 

  • Lown, B.: In 14th Hahnemann symposium on mechanisms and therapy of cardiac arrhythmias, Edited by Dreifus, L., Likoff, W., Moyer, J., Philadelphia, Grune Stratton, 1966, p. 185

    Google Scholar 

  • Lu, H.H., Lange, G., Brooks, C.McC.: Factors controlling pacemaker action in cells of the siroatrial node. Circ Res 17: 460, 1965

    PubMed  CAS  Google Scholar 

  • Mandel, W.J., Hayakawa, H., Danzig, R., Marcus, H.S.: Evaluation of sino-atrial node function in man by overdrive suppression. Circulation 44: 59, 1971

    PubMed  CAS  Google Scholar 

  • Mandel, W.J., Laks M.M.: Overview of the sick sinus syndrome. Chest 66: 223, 1974

    Article  PubMed  CAS  Google Scholar 

  • Mandel, W.J., Laks, M.M., Obayashi, K.: Sinus node function: Evaluation in patients with and without sinus node disease. Arch Int Med 135: 388, 1975

    Article  CAS  Google Scholar 

  • Masini, 0., Dianda, R., Grazina, A.: Analysis of sinoatrial conduction in man using premature atrial stimulation. Cardiovasc Res 9: 498, 1975

    Article  PubMed  CAS  Google Scholar 

  • Metzger, A.L., Goldberg, A.N., Hunter, R.L.: Sick sinus node syndrome as the presenting manifestation of reticulum cell sarcoma. Chest 60: 602, 1971

    Article  PubMed  CAS  Google Scholar 

  • Miller, H.C., Strauss, H.C.: Measurement of sinoatrial conduction time by premature atrial stimulation in the rabbit. Circ Res 35: 935, 1974

    PubMed  CAS  Google Scholar 

  • Moss, A.J., Davis, R.J.: Brady-tachy syndrome. Frog Cardiovasc Dis 16: 439, 1974

    Article  CAS  Google Scholar 

  • Narula, O.S.: Sinus node reentry. A mechanism for supraventricular tachycardia. Circulation 50: 114, 1974

    Google Scholar 

  • Narula, O.S., Samet, P., Javier, R.P.: Significance of the sinus node recovery time. Circulation 45: 140, 1972

    PubMed  CAS  Google Scholar 

  • Okimoto, T., Veda, K., Kamata, C., Yoshida, H., Ohkawa, S., Hiracka, K., Kuwajima, I., Sugiura, M., Murakami, M., Matsuo, H.: Sinus node recovery time and abnormal post-pacing phase in the aged patients with sick sinus syndrome. Japan Heart J 17: 290, 1976

    Article  CAS  Google Scholar 

  • Paritsky, Z., Obayashi, K., Mandel, W.J.: Atrial tachycardia secondary to sino-atrial node reentry. Chest 66: 526, 1974

    Article  Google Scholar 

  • Pasmooij, J.H., Van Enst G.C., Bouman, L.N., Allessie, M.A., Bonke, F.I.M.: The effect of heart rate on the membrane responsiveness of rabbit atrial muscle. Pflügers Arch 366: 223, 1976

    Article  PubMed  CAS  Google Scholar 

  • Paulay, K.L., Varghese, P.J., Damato, A.N.: Atrial rhythms in response to an early atrial premature depolarization in man. Am Heart J 85: 323, 1973a.

    Article  Google Scholar 

  • Paulay, K.L., Varghese, P.J., Damato, A.N.: Sinus node reentry: An in vivo demonstration in the dog. Circ Res 32: 455, l973b

    Google Scholar 

  • Radford, D.J., Julian, D.G.: Sick sinus syndrome: Experience of a cardiac pacemaker clinic. Br Med J 3: 504, 1974

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen, K.: Chronic sinoatrial heart block. Am Heart J 81: 38, 1971

    Article  Google Scholar 

  • Reiffel, J.A., Bigger, J.T., Konstam, M.A.: The relationship between sinoatrial conduction time and sinus cycle length during spontaneous sinus arrhythmia in adults. Circulation 50: 924, 1974

    PubMed  CAS  Google Scholar 

  • Reiffel, J.P., Bigger, J.T., Giardina, E.-G.V.: “Paradoxical” prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. Am J Cardiol 36: 98, 1975

    Article  PubMed  CAS  Google Scholar 

  • Rokseth, R., Hatle, L.: Prospective study on the occurrence and management of chronic sinoatrial disease with follow-up. Br Heart J 36: 582, 1974

    Article  PubMed  CAS  Google Scholar 

  • Rosen, K.M., Loeb, H.S., Sinno, M.Z., Rahimtoola, S.H., Gunnar, R.M.: Cardiac conduction in patients with symptomatic sinus node disease. Circulation 43: 836, 1971.

    PubMed  CAS  Google Scholar 

  • Rosen, M.R., Wit, A.L., Hoffman, B.F.: Electrophysiology and pharmacology of cardiac arrhythmias. IV. Cardiac antiarrhythmic and toxic effects of digitalis. Am Heart J 89: 391, 1975

    Article  PubMed  CAS  Google Scholar 

  • Rubenstein, J.J., Schulman, C.L., Yurchack, P.M., et al.: Clinical spectrum of the sick sinus syndrome. Circulation 46: 5, 1972

    PubMed  CAS  Google Scholar 

  • Sano, T., Yamagishi, S.: Spread of excitation from the sinus node. Circ Res 16: 423, 1965

    PubMed  CAS  Google Scholar 

  • Saroff, A., Strauss, H.C., Bigger, J.T., Steiner, C., Giardina, E.-G.V.: Evaluation of sinus node function in patients with sinus bradycardia. Circulation 44: II–97, 1971

    Google Scholar 

  • Scheinman, M.M., Kunkel, F.W., Peter, R.W., Schoenfeld, P.L., Abbott, J.A.: Sino-atrial function and atrial refractoriness in patients with sick sinus syndrome. Circulation 48: IV–2l5, 1973

    Google Scholar 

  • Scheinman, M.M., Peter, R., Hirschfeld, D.S., Abbott, J.A., Kunkel, F.W.: The sick sinus and failing atrium. West J Med 121: 473, 1974

    PubMed  CAS  Google Scholar 

  • Scher, A.M., Rodrigues, M.I., Lukane, J., Young, A.C.: The mechanism of atrio-ventricular conduction. Circ Res 7: 54, 1959

    PubMed  CAS  Google Scholar 

  • Scherf, D.: The mechanisms of sinoatrial block. Am J Cardiol 23: 769, 1969

    Article  PubMed  CAS  Google Scholar 

  • Scherlag, B.J., Abelleira, J.L., Narula, O.S., Samet, P.: The differential effects of ouabain on sinus, AV nodal, His bundle and idioventricular rhythms. Am Heart J 81: 227, 1971

    Article  PubMed  CAS  Google Scholar 

  • Seipel, L., Both, A., Breithardt, G., Gleichman, U., Loogen, F.: Action of antiarrhythmic drugs on His bundle electrogram and sinus node function. Acta Cardiol XVIII: 251, 1974

    Google Scholar 

  • Sigurd, B., Jensen, G., Meibom, J., Sandoe, E.: Adams-Stokes syndrome caused by sinoatrial block. Br Heart J 35: 1002, 1973

    Article  PubMed  CAS  Google Scholar 

  • Sowton, E., Hendrix, G., Roy, P.: Ten-year survey of treatment with implanted cardiac pacemaker. Brit Med J 3: 155, 1974

    Article  PubMed  CAS  Google Scholar 

  • Spellberg, R.D.: Familial sinus node disease. Chest 60: 246, 1971

    Article  PubMed  CAS  Google Scholar 

  • Steinbeck, G., Lüderitz, B.: Comparative study of sinoatrial conduction time and sinus node recovery time. Br Heart J 37: 956, 1975

    Article  PubMed  CAS  Google Scholar 

  • Strauss, H.C., Bigger, J.T.: Electrophysiological properties of the rabbit sinoatrial perinodal fibers. Circ Res 31: 490, 1972

    PubMed  CAS  Google Scholar 

  • Strauss, H.C., Saroff, A.L., Bigger, J.T., Giardina E.-G.V.: Premature atrial stimulation as a key to the understanding of sinoatrial conduction in man. Presentation of data and cirtical review of the literature. Circulation 47: 86, 1973

    PubMed  CAS  Google Scholar 

  • Strauss, H.C., Saroff, A.L., Bigger, J.T.: Slowed conduction, block and reentry in perinodal fibers. Circulation 43 and 44, suppl. II, 1974

    Google Scholar 

  • Strauss, H.C., Gilbert, M., Svenson, R., Miller, H.C., Wallace, A.G.: Electrophysiologic effects of propranolol on sinus node function in patients with sinus node dysfunction. Circulation 54: 452, 1976a

    PubMed  CAS  Google Scholar 

  • Strauss, H.C., Bigger, J.T., Saroff, A.L., Giardina, E.-G.V.: Electrophysiologic evaluation of sinus node function in patients with sinus node dysfunction. Circulation 53: 763, 1976b

    PubMed  CAS  Google Scholar 

  • Szekeres, L., Papp, G.J.: Experimental cardiac arrhythmias and antiarrhythmic drugs. Budapest, Akademiai Kiado, 1971

    Google Scholar 

  • Ten Eick, R.E., Hoffman, B.F.: Chronotropic effect on cardiac glycosides in dogs, cats, and rabbits. Circ Res 25: 365, 1969

    PubMed  CAS  Google Scholar 

  • Toda, N., West, T.C.: Influence of ouabain on chalinergic responses in sonoatrial node. J. Pharmacol Exp Ther 153: 104, 1966

    PubMed  CAS  Google Scholar 

  • Vincenzi, F.F., West, T.C.: Release of autonomic mediators in cardiac tissue by direct subthreshold electrical stimulation. J Pharmacol Exp Ther 141: 185, 1963

    PubMed  CAS  Google Scholar 

  • Wan, S.H., Lee, G.S., Ton, C.S.: The sick sinus syndrome. A study of 15 cases. Br Heart J 34: 942, 1972

    Article  PubMed  CAS  Google Scholar 

  • Ward, P.C.: A new familial cardiac syndrome in children. J Irish Med Assoc 54: 103, 1964

    CAS  Google Scholar 

  • Yabek, SM., Jarmakani, J.M., Robert, N.K.: Sinus node function in children. Factors influencing its evaluation. Circ 53: 28, 1976

    CAS  Google Scholar 

  • Yamaguchi, I., Mandel, W.J.: The effect of stimulation site on electrophysiologic features of the sinus node. Am J Cardiol 41: 374, 1978

    Article  Google Scholar 

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  1. Jay L. Jordan
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  2. Iwao Yamaguchi
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  3. William J. Mandel
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  1. Dept. of Physiology, Biomedical Center, University of Limburg, Maastricht, The Netherlands

    Felix I. M. Bonke

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Jordan, J.L., Yamaguchi, I., Mandel, W.J. (1978). Function and Dysfunction of the Sinus Node: Clinical Studies in the Evaluation of Sinus Node Function. In: Bonke, F.I.M. (eds) The Sinus Node. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9715-8_1

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  • DOI: https://doi.org/10.1007/978-94-009-9715-8_1

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