Abstract
In this report, normal lymphocytes from bovine lymph nodes have been used to study the metabolic interactions of tumor promoting phorbol esters and antitumor-promoting retinoids. As shown earlier with this model system, 12-0-tetradecanoylphorbol-13-acetate (TPA) and related tumor-promoting phorbol esters act as co-mitogens in cells treated with a suboptimal level of phytohemagglutinin (PHA) or concanavalin A (con A) (1,2). This mitogenic response, as measured by an increase in the level of DNA synthesis in cultures 48 hours after the initiation of TPA-PHA treatment, is prevented when the cultures are treated simultaneously with retinoic acid (RA) or a related retinoid with anti-tumor promoting activity in mouse skin. This antagonism by RA was also seen in the case of the co-induction of ornithine decarboxylase (ODC) activity by the combination of PHA and TPA during the first 18 hours in such cultures (3).
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Mastro, A. M., and Mueller, G. C.: 1974, Exp. Cell Res. 88, pp. 40–46.
Kensler, T. W., and Mueller, G. C.: 1978, Cancer Res. 38, pp. 771–775.
Kensler, T. W., Verraa, A. K., Boutwell, R. K., and Mueller, G. C.: 1978, Cancer Res. 38, pp. 2896–2899.
Kensler, T. W., Wertz, P. W., and Mueller, G. C.: 1979, Biochim. Biophys. Acta 585, p. 43–52.
Wertz, P. W., and Mueller, G. C.: 1978, Cancer Res. 38, pp. 2900–2904.
Wertz, P. W., Kensler, T. W., Mueller, G. C., Verma, A. K., and Boutwell, R. K.: 1979, Nature 277, pp. 227–229.
Wertz, P. W., Mueller, G. C.: 1980, Cancer Res. 40, pp. 776–781.
DeChatelet, L. R., Shirley, P. S., and Johnson, R. B.: 1976, Blood 47, pp. 545–554.
Kaplan, L., Weiss, J., and Elsbach, P.: 1978, Proc. Natl. Acad. Sci. U.S.A. 75, pp. 2955–2958.
Vance, D. E., and Choy, P. C.: 1979, Trends in Biol. Sci. 4, pp. 145–148.
Choy, P. C., and Vance, D. E. 1978, J. Biol. Chem. 253, pp. 5163–5167.
Schneider, W. C., and Behki, R. M.: 1963, J. Biol. Chem. 238, pp. 3565–3571.
Fiscus, W. G., and Schneider, W. C.: 1966, J. Biol. Chem. 241, pp. 3324–3330.
Kennedy, E. P.: 1962, The Harvey Lectures 57, pp. 143–171.
Driedger, P. E., and Blumberg, P. M.: 1980, Proc. Natl. Acad. Sci. U.S.A. 77, pp. 567–571.
Estensen, R. D., DeHoogh, D. K., and Cole, C. F.: 1980, Cancer Res. 40, pp. 1119–1124.
Kwong, C. H., and Mueller, G. C.: 1979, Biochim. Biophys. Acta 586, pp. 501–511.
Mueller, G. C.: 1980, in “Estrogens in the Environment” (ed.) John A. McLachlan, Elsevier North Holland, Inc. New York, in press.
Mueller, G. C., Kajiwara, K., Kim, U. H., and Graham, J.: 1978, Cancer Res. 38, pp. 4041–4045.
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Mueller, G.C., Wertz, P.W., Kwong, C.H., Anderson, K., Wrighton, S.A. (1980). Dissection of the Early Molecular Events in the Activation of Lymphocytes by 12-0-Tetradecanoylphorbol-13-Acetate. In: Pullman, B., Ts’o, P.O.P., Gelboin, H. (eds) Carcinogenesis: Fundamental Mechanisms and Environmental Effects. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9104-0_26
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DOI: https://doi.org/10.1007/978-94-009-9104-0_26
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