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Pathology of Central-Nervous-System Diseases in Childhood Leukemia

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Neuro-Oncology

Part of the book series: Developments in Oncology ((DION,volume 3))

Abstract

Before the 1950’s, the prognosis for children who developed acute lymphocytic leukemia was uniformly poor. Despite therapy that included transfusions and occasionally irradiation to enlarge the viscera and mediastinal masses, 50% of all children who developed this disease died during the first six months following diagnosis and rarely did a child survive beyond nine months (1). Late in the 1940’s, Dr. Farber and his associates succeeded in achieving temporary remissions in five children with leukemia by using the folic acid antagonist 4-aminopterol glutamic acid (2). This success lead to the development of more potent anti-leukemic drugs capable of prolonging initial remissions.

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Authors
  1. R. A. Price
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Editor information

Editors and Affiliations

  1. The Netherlands Cancer Institute, Municipal Hospital Slotervaart, Amsterdam, The Netherlands

    B. W. Ongerboer de Visser (Neurologist) (Neurologist)

  2. Neurosurgeon, University Hospital, Groningen, The Netherlands

    D. A. Bosch

  3. Rotterdamsch Radiotherapeutisch Instituut, Rotterdam, The Netherlands

    W. M. H. van Woerkom-Eykenboom (Radiotherapist) (Radiotherapist)

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© 1980 Martinus Nijhoff Publishers bv, The Hague

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Price, R.A. (1980). Pathology of Central-Nervous-System Diseases in Childhood Leukemia. In: Ongerboer de Visser, B.W., Bosch, D.A., van Woerkom-Eykenboom, W.M.H. (eds) Neuro-Oncology. Developments in Oncology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8919-1_17

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  • DOI: https://doi.org/10.1007/978-94-009-8919-1_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8921-4

  • Online ISBN: 978-94-009-8919-1

  • eBook Packages: Springer Book Archive

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