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Small Cell Bronchogenic Carcinoma: A Review of Therapeutic Results

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Lung Cancer 1

Part of the book series: Cancer Treatment and Research ((CTAR,volume 1))

Abstract

Small cell bronchogenic carcinoma (SCBC) accounts for 20–25% of all lung cancers in the United States. It is estimated that there are 20,000–25,000 cases per year. Recent studies have shown that SCBC is biologically different from the other lung cancer cell types [1,2]. The natural history and response to therapy are also markedly different from the non-small cell histologic groups [1,3]. Untreated patients have median survivals of only 6–17 weeks and less than 1% of patients are alive 5 years following surgical treatments [4–6]. Radiotherapy alone has been shown to be superior to surgery alone for patients with limited disease stages; however, mean survival for these early stage patients treated with radiotherapy alone is short (43 weeks), and less than 1–5% of patients are alive at 5 years [1,6]. Systemic chemotherapy has made a dramatic impact on survival. Several useful reviews of single agent and combination chemotherapy have recently been published [1,7–10].

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References

  1. Bunn PA, Cohen MH, Ihde DC et al.: Advances in small cell bronchogenic carcinoma. Cancer Treat Rep 61:333–342, 1977.

    PubMed  Google Scholar 

  2. Tischler AS: Small cell carcinoma of the lung: Cellular origin and relationship to other neoplasms. Semin Oncol 5:244–252, 1978.

    PubMed  CAS  Google Scholar 

  3. Cohen MH, Matthews MJ: Small cell bronchogenic carcinoma: A distinct clinicopathologic entity. Semin Oncol 5:234–243, 1978.

    PubMed  CAS  Google Scholar 

  4. Zelen M: Keynote address on biostatistics and data retrieval. Cancer Chemother Rep (Part 3) 4(2):31–42, 1973.

    CAS  Google Scholar 

  5. Mountain CF: Clinical biology of small cell bronchogenic carcinoma: Relationship to surgical therapy. Semin Oncol 5:272–279, 1978.

    PubMed  CAS  Google Scholar 

  6. Fox W, Scadding JG: Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Ten year follow-up. Lancet 2:63–65, 1973.

    PubMed  CAS  Google Scholar 

  7. Broder LE, Cohen MH, Selawry OS: Treatment of bronchogenic carcinoma. II. Small cell cancer. Cancer Treat Rev 4:219–260, 1977.

    PubMed  CAS  Google Scholar 

  8. Weiss RB: Small-cell carcinoma of the lung: Therapeutic management. Ann Intern Med 88:522–531, 1978.

    PubMed  CAS  Google Scholar 

  9. Cohen MH, Fossieck BE, Ihde DC et al.: Chemotherapy of small cell carcinoma of the lung: Results and concepts. In: Lung Cancer, Muggia FM, Rozencwieg M (eds), New York, Raven Press, 1979, p 559–568.

    Google Scholar 

  10. Bunn PA, Cohen MH. Ihde DC et al.: A review of recent therapeutic trials in small cell bronchogenic carcinoma. In: Lung Cancer, Muggia FM, Rozencwieg M (eds), New York, Raven Press, 1979, p 549–557.

    Google Scholar 

  11. Matthews MJ, Kanhouwa S, Pickren J et al: Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer. Cancer Chemo Rep (Part 3) 4(2):63–67, 1973.

    CAS  Google Scholar 

  12. Higgins GA: Use of chemotherapy as an adjuvant to surgery for bronchogenic carcinoma. Cancer 30:1382–1387, 1972.

    Google Scholar 

  13. Medical Research Council Working Party: Study of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus. Br Med J 2:421–428, 1971.

    Google Scholar 

  14. Shields TW, Humphrey EW, Eastridge CE et al.: Adjuvant cancer chemotherapy after resection of carcinoma of the lung. Cancer 40:2057–2062, 1977.

    PubMed  CAS  Google Scholar 

  15. Karrer K, Pridun N, Denck H: Chemotherapy as an adjuvant to surgery in lung cancer. Cancer Chemother Pharmacol 1:145–159, 1978.

    PubMed  CAS  Google Scholar 

  16. Meyer JA, Comis RL, Ginsberg SJ et al.: Selective surgical resection in small cell carcinoma of the lung. J Thorac Cardiovasc Surg 77:243–248, 1979.

    PubMed  CAS  Google Scholar 

  17. Mandelbaum I, Williams SD, Hornback NB et al.: Combined therapy for small cell undif-ferentiated carcinoma of the lung. J Thorac Cardiovasc Surg 76:292–296, 1978.

    PubMed  CAS  Google Scholar 

  18. Edmonson JH, Lagakos SW, Selawry OS et al: Cyclophosphamide and CCNU in the treatment of inoperable small cell carcinoma and adenocarcinoma of the lung. Cancer Treat Rep 60:925–932, 1976.

    PubMed  CAS  Google Scholar 

  19. Tucker RD, Sealy R, van Wyk C et al.: A clinical trial of cyclophosphamide (NSC-26271) and radiation therapy for oat cell carcinoma of the lung. Cancer Chemother Rep (Part 3) 4(2): 159–160, 1973.

    CAS  Google Scholar 

  20. Kaung DT, Wolf J, Hyde L et al.: Preliminary report on the treatment of nonresectable cancer of the lung. Cancer Chemother Rep 58:359–364, 1974.

    PubMed  CAS  Google Scholar 

  21. Laing A, Berry R: Treatment of small cell carcinoma of bronchus. Lancet 1:129–132, 1975.

    PubMed  CAS  Google Scholar 

  22. Carr DT, Childs DS, Lee RE: Radiotherapy plus 5-FU compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma. Cancer 29:375–380, 1972.

    PubMed  CAS  Google Scholar 

  23. Bergsagel D, Jenkin R, Pringle J et al.: Lung cancer: Clinical trial of radiotherapy alone vs. radiotherapy plus cyclophosphamide. Cancer 30:621–627, 1972.

    PubMed  CAS  Google Scholar 

  24. Host H: Cyclophosphamide (NSC-26271) as adjuvant to radiotherapy in the treatment of unresectable bronchogenic carcinoma. Cancer Chemother Rep (Part 3) 4(2): 161–164, 1973.

    CAS  Google Scholar 

  25. Petrovich Z, Mietlowski W, Ohanian M et al.: Clinical report on the treatment of locally advanced lung cancer. Cancer 40:72–77, 1977.

    PubMed  CAS  Google Scholar 

  26. Petrovich Z, Ohanian M, Cox J: Clinical research on the treatment of locally advanced lung cancer. Cancer 42:1129–1134, 1978.

    PubMed  CAS  Google Scholar 

  27. Medical Research Council Lung Cancer Working Party: Radiotherapy alone or with chemotherapy in the treatment of small-cell carcinoma of the lung. Br J Cancer 40:1–10, 1979.

    Google Scholar 

  28. Matthiessen W: Controlled clinical trial of radiotherapy alone, against radiotherapy plus chemotherapy in small-cell carcinoma of the lung: Comparison of radiation damage. Scand J Resp Dis Suppl 102:209–211, 1978.

    CAS  Google Scholar 

  29. Green RA, Humphrey E, Close H et al.: Alkylating agents in bronchogenic carcinoma. Am J Med 46:516–525, 1969.

    PubMed  CAS  Google Scholar 

  30. Cavalli F, Sonntag RW, Jungi F et al.: VP-16-213 monotherapy for remission induction of small cell lung cancer: A randomized trial using three dosage schedules. Cancer Treat Rep 62:473–475, 1978.

    PubMed  CAS  Google Scholar 

  31. Wolf J: Nitrosoureas as single agents in the treatment of pulmonary cancer. Cancer Treat Rep 60:753–756, 1976.

    PubMed  CAS  Google Scholar 

  32. Wilson WL, Van Ryzin J, Weiss AJ et al.: A Phase III study in lung carcinoma comparing hexamethylmelamine to dibromodulcitol. Oncology 31:293–309, 1975.

    PubMed  CAS  Google Scholar 

  33. Bunn PA, Ihde DC, Cohen MH et al.: Streptozotocin in advanced small cell bronchogenic carcinoma: An ineffective nonmyelosuppressive agent. Cancer Treat Rep 62:479–481, 1978.

    PubMed  Google Scholar 

  34. Kane RC, Bernath AM, Cashdollar MR: Phase II trial of streptozotocin for small cell anaplastic carcinoma of the lung. Cancer Treat Rep 62:477–478, 1978.

    PubMed  CAS  Google Scholar 

  35. Samson MK, Baker LH, Talley RW et al.: VM26: A clinical study in advanced cancer of the lung and ovary. Eur J Cancer 14:1395–1399, 1978.

    PubMed  CAS  Google Scholar 

  36. Cavalli F, Jungi WF, Sonntag RW et al.: Phase II trial of cis-Dichlorodiammineplatinum (II) in advanced malignant lymphoma and small cell lung cancer: Preliminary results. Cancer Treat Rep 63:1599–1603, 1979.

    PubMed  CAS  Google Scholar 

  37. Dombernowsky P, Sorenson S, Aisner J et al.: Cis-Dichlorodiammineplatinum (II) in small cell anaplastic bronchogenic carcinoma: A Phase II study. Cancer Treat Rep 63:543–545, 1979.

    PubMed  CAS  Google Scholar 

  38. Sierocki JS, Hilaris BS, Hopfan S et al.: Cis-Dichlorodiammineplatinum (II) and VP-16-213: An active induction regimen for small cell carcinoma of the lung. Cancer Treat Rep 63:1593–1597, 1979.

    PubMed  CAS  Google Scholar 

  39. Greco FA, Einhorn LH, Richardson RL et al.: Small cell lung cancer: Progress and perspectives. Semin Oncol 5:323–335, 1978.

    PubMed  CAS  Google Scholar 

  40. Maurer LH, Tulloh M, Weiss RB et al.: A randomized combined modality trial in small cell carcinoma of the lung: Comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy, effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 45:30–39, 1980.

    PubMed  CAS  Google Scholar 

  41. Lowenbraun S, Bartolucci A, Smalley RV et al.: The superiority of combination chemotherapy over single agent chemotherapy in small cell lung carcinoma. Cancer 44:406–413, 1979.

    PubMed  CAS  Google Scholar 

  42. Eagan RT, Carr DT, Frytak S et al.: VP-16-213 versus polychemotherapy in patients with advanced small cell lung cancer. Cancer Treat Rep 60:949–951, 1976.

    PubMed  CAS  Google Scholar 

  43. Alberto P, Brunner KW, Martz G et al.: Treatment of bronchogenic carcinoma with simultaneous or sequential combination chemotherapy, including methotrexate, cyclophos-phamide, procarbazine, and vincristine. Cancer 38:2208–2216, 1976.

    PubMed  CAS  Google Scholar 

  44. Hansen HH, Selawry OS, Simon R et al.: Combination chemotherapy of advanced lung cancer: A randomized trial. Cancer 38:2201–2207, 1976.

    PubMed  CAS  Google Scholar 

  45. Hansen HH, Dombernowsky P, Hansen M et al.: Chemotherapy of advanced small cell anaplastic carcinoma: Superiority of a four-drug combination to a three-drug combination. Ann Intern Med 89:177–181, 1978.

    PubMed  CAS  Google Scholar 

  46. Aisner J, Wiernik PH, Esterhay RJ: Treatment of small cell carcinoma of the lung with cyclophosphamide, adriamycin, and VP16-213 with or without MER. In: Adjuvant Therapy of Cancer, Salmon SE, Jones SE (eds), Amsterdam, Elsevier/North Holland Biomedicai Press, 1977, p 245–250.

    Google Scholar 

  47. Stevens E, Einhorn L, Rohn R: Treatment of limited small cell lung cancer. Proc AACR and ASCO 20:435, 1979.

    Google Scholar 

  48. Cohen MH, Ihde DC, Bunn PA et al.: Cyclic alternating chemotherapy for small cell bronchogenic carcinoma. Cancer Treat Rep 63:163–170, 1979.

    PubMed  CAS  Google Scholar 

  49. Hansen HH, Dombernowsky P, Hansen HS et al.: Chemotherapy versus chemotherapy plus radiotherapy in regional small cell carcinoma of the lung. A randomized trial. Proc AACR and ASCO 20:277, 1979.

    Google Scholar 

  50. Israel L, Depierre A, Choffel C et al.: Immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete remissions. Cancer Treat Rep 61:343–347, 1977.

    PubMed  CAS  Google Scholar 

  51. Ettinger DS, Karp JE, Abeloff MD et al.: Intermittent high-dose cyclophosphamide chemotherapy for small cell carcinoma of the lung. Cancer Treat Rep 62:413–424, 1978.

    PubMed  CAS  Google Scholar 

  52. Straus MJ: Cytokinetic chemotherapy design for the treatment of advanced lung cancer. Cancer Treat Rep 63:767–773, 1979.

    PubMed  CAS  Google Scholar 

  53. Trowbridge RC, Kennedy BJ, Vosika GJ: CCNU-adriamycin therapy in bronchogenic carcinoma. Cancer 41:1704–1709, 1978.

    PubMed  CAS  Google Scholar 

  54. Holoye PY, Samuels ML: Cyclophosphamide, vincristine and sequential split-course radiotherapy in the treatment of small cell lung cancer. Chest 67:675–679, 1975.

    PubMed  CAS  Google Scholar 

  55. Cohen MH, Creaven PJ, Fossieck BE et al.: Intensive chemotheràpy of small cell bronchogenic carcinoma. Cancer Treat Rep 61:349–354, 1977.

    PubMed  CAS  Google Scholar 

  56. Saiontz HI, Dalton RJ, Eagan RT: Cyclophosphamide, adriamycin, and DTIC polychemo-therapy in advanced small cell lung cancer. Cancer Treat Rep 61:481–483, 1977.

    PubMed  CAS  Google Scholar 

  57. Holoye PY, Samuels ML, Lanzotti VJ et al..: Combination chemotherapy and radiation therapy for small cell carcinoma. JAMA 237:1221–1224, 1977.

    PubMed  CAS  Google Scholar 

  58. Einhorn LH, Fee WH, Farber MO et al.: Improved chemotherapy for small cell undiffer-entiated lung cancer. JAMA 235:1225–1229, 1976.

    PubMed  CAS  Google Scholar 

  59. Alberto P: Remission rates, survival and prognostic factors in combination chemotherapy for bronchogenic carcinoma. Cancer Chemo Rep (Part 3) 4(2): 199–206, 1973.

    CAS  Google Scholar 

  60. Dombernowsky P, Hansen HH, Sorenson S et al.: Sequential versus non-sequential combination chemotherapy using 6 drugs in advanced small cell carcinoma: A comparative trial including 146 patients. Proc AACR and ASCO 20:277, 1979.

    Google Scholar 

  61. Williams C, Alexander M, Glatstein EJ et al.: The role of radiation therapy in combination with chemotherapy in extensive oat cell cancer of the lung. A randomized study. Cancer Treat Rep 61:1427–1431, 1977.

    PubMed  CAS  Google Scholar 

  62. Abeloff MD, Ettinger DS, Khouri NF et al.: Intensive induction therapy for small cell carcinoma of the lung. Cancer Treat Rep 63:519–524, 1979.

    PubMed  CAS  Google Scholar 

  63. Chahinian AP, Mandel EM, Holland JF et al.: MACC (methotrexate, adriamycin, cyclophosphamide, and CCNU) in advanced lung cancer. Cancer 43:1590–1597, 1979.

    PubMed  CAS  Google Scholar 

  64. Sarna GP, Lowitz BB, Haskell CM et al.: Chemo-immunotherapy for unresectable bronchogenic carcinoma. Cancer Treat Rep 62:681–687, 1978.

    PubMed  CAS  Google Scholar 

  65. Nixon DW, Carey RW, Suit HD et al.: Combination chemotherapy in oat cell carcinoma of the lung. Cancer 36:867–872, 1975.

    PubMed  CAS  Google Scholar 

  66. Johnson RE, Brereton HD, Kent CH: ‘Total’ therapy for small cell carcinoma of the lung. Ann Thorac Surg 25:509–515, 1978.

    Google Scholar 

  67. Greco FA, Richardson RL, Snell JD et al.: Small cell lung cancer: Complete remission and improved survival. Am J Med 66:625–630, 1979.

    PubMed  CAS  Google Scholar 

  68. Einhorn LH, Bond WH, Hornback W et al.: Long term results in combined modality treatment of small cell carcinoma of the lung. Semin Oncol 5:309–313, 1978.

    PubMed  CAS  Google Scholar 

  69. Kane RC, Cohen MH, Broder LE et al.: Superior vena cavai obstruction due to small cell anaplastic lung carcinoma: Response to chemotherapy. JAMA 235:1717–1718, 1976.

    PubMed  CAS  Google Scholar 

  70. Dombernowsky P, Hansen HH: Combination chemotherapy in the management of superior vena cavai obstruction in small call anaplastic carcinoma of the lung. Acta Med Scand 204:513–516, 1978.

    PubMed  CAS  Google Scholar 

  71. Nugent JL, Bunn PA, Matthews MJ et al.: CNS metastases in small cell bronchogenic carcinoma. Cancer 44:1885–1893, 1979.

    PubMed  CAS  Google Scholar 

  72. Jackson DV, Richards F, Cooper MR et al.: Prophylactic cranial irradiation in small cell carcinoma of the lung. A randomized study. JAMA 237:2730–2733, 1977.

    PubMed  Google Scholar 

  73. Holoye PY, Samuels ML, Smith T et al.: Chemoimmunotherapy of small ceil bronchogenic carcinoma. Cancer 42:34–40, 1978.

    PubMed  CAS  Google Scholar 

  74. McCracken J, White J, Reed R et al.: Combination chemotherapy, radiotherapy, and immu-notherapy for oat cell carcinoma of the lung. Proc AACR and ASCO 19:395, 1978.

    Google Scholar 

  75. Cohen MH, Chretien PB, Ihde DC et al.: Thymosin Fraction V and intensive combination chemotherapy: Prolonging the survival of patients with small cell lung cancer. JAMA 241:1813–1815, 1979.

    PubMed  CAS  Google Scholar 

  76. Hattori S, Matsuda M, Ikegami H et al.: Small cell carcinoma of the lung: Clinical and cytomorphological studies in relation to its response to chemotherapy. Gann 68:321–332, 1977.

    PubMed  CAS  Google Scholar 

  77. Herman TS, Jones SE, McMahon LG et al.: Combination chemotherapy with adriamycin and cyclophosphamide (with or without radiation therapy) for carcinoma of the lung. Cancer Treat Rep 61:875–879, 1977.

    PubMed  CAS  Google Scholar 

  78. McMahon LJ, Herman TS, Manning MR et al.: Patterns of relapse in patients with small cell carcinoma of the lung treated with adriamycin-cyclophosphamide chemotherapy and radiation therapy. Cancer Treat Rep 63:359–362, 1979.

    PubMed  CAS  Google Scholar 

  79. Eagan RT, Carr DT, Lee RE et al.: Phase II studies of polychemotherapy regimens in small cell lung cancer. Cancer Treat Rep 61:93–95, 1977.

    PubMed  CAS  Google Scholar 

  80. King GA, Comis R, Ginsberg S et al.: Combination chemotherapy and radiotherapy in small cell carcinoma of the lung. Radiology 125:529–530, 1977.

    PubMed  CAS  Google Scholar 

  81. Ginsberg SJ, Comis RL, Gottlieb AJ et al.: Long-term survivorship in small-cell anaplastic lung carcinoma. Cancer Treat Rep 63:1347–1349, 1979.

    PubMed  CAS  Google Scholar 

  82. Livingston RB, Moore TN, Heilbrun L et al.: Small cell carcinoma of the lung: Combined chemotherapy and radiation. Ann Intern Med 88:194–199, 1978.

    PubMed  CAS  Google Scholar 

  83. Hornback NB, Einhorn L, Shidnia H et al.: Oat cell carcinoma of the lung. Early treatment results of combination radiation therapy and chemotherapy. Cancer 37:2658–2664, 1976.

    PubMed  CAS  Google Scholar 

  84. Johnson RE, Brereton HD, Kent CH: Small-cell carcinoma of the lung: Attempt to remedy causes of past therapeutic failure. Lancet 2:289–291, 1976.

    PubMed  CAS  Google Scholar 

  85. Wittes RE, Hopfan S, Hilaris B et al.: Oat cell carcinoma of the lung: Combination treatment with radiotherapy and cyclophosphamide, adriamycin, vincristine, and methotrex-ate. Cancer 40:653–659, 1977.

    PubMed  CAS  Google Scholar 

  86. Alexander M, Glatstein EJ, Gordon DS et al.: Combined modality treatment for oat cell carcinoma of the lung. A randomized trial. Cancer Treat Rep 61:1–6, 1977.

    PubMed  CAS  Google Scholar 

  87. Eagan RT, Maurer H, Forcier RJ et al.: Combination chemotherapy and radiation therapy in small cell carcinoma of the lung. Cancer 32:371–379, 1973.

    PubMed  CAS  Google Scholar 

  88. Bitran J, Golomb HM, Desser RK et al.: Prolonged survival of patients with extensive oat cell carcinoma treated with radiotherapy and cyclophosphamide (NSC-26271), vincristine (NSC-67574), and methotrexate (NSC-740). Cancer Treatment Rep 60:221–223, 1976.

    CAS  Google Scholar 

  89. Greco FA, Richardson RL, Schulman SF et al.: Treatment of oat cell carcinoma of the lung: Complete remissions, acceptable complications, and improved survival. Br Med J 2:10–11, 1978.

    PubMed  CAS  Google Scholar 

  90. Cox JD, Byhardt RW, Wilson JF et al.: Dose-time relationships and the local control of small cell carcinoma of the lung. Radiology 128:205–207, 1978.

    PubMed  CAS  Google Scholar 

  91. Cox JD, Byhardt R, Komaki R et al.: Interaction of thoracic irradiation and chemotherapy on local control and survival in small cell carcinoma of the lung. Cancer Treat Rep 63:1251–1255, 1979.

    PubMed  CAS  Google Scholar 

  92. Abeloff MD, Ettinger DS, Baylin SB et al.: Management of small cell carcinoma of the lung. Therapy, staging and biochemical markers. Cancer 38:1394–1401, 1976.

    PubMed  CAS  Google Scholar 

  93. Gilby ED, Bondy PK, Morgan RL et al.: Combination chemotherapy for small cell carcinoma of the lung. Cancer 39:1959–1966, 1977.

    PubMed  CAS  Google Scholar 

  94. Osieka R, Schmidt CG, Makoski HB et al.: The combined modality approach in the treatment of inoperable small-cell anaplastic carcinoma of the lung. Z Krebsforsch 89:9–18, 1977.

    CAS  Google Scholar 

  95. Burdon JGW, Henderson MM, Moan WJ et al.: Combined chemotherapy and radiotherapy for the treatment of small cell carcinoma of the lung. Med J Aust 1:353–355, 1978.

    PubMed  CAS  Google Scholar 

  96. Burdon JGW, Sinclair RA, Henderson MM: Small cell carcinoma of the lung. Chest 76:302–304, 1979.

    PubMed  CAS  Google Scholar 

  97. Cohen MH, Lichter AS, Bunn PA et al.: Chemotherapy-radiation therapy (CT-RT) versus chemotherapy (CT) in limited small cell lung cancer (SCCL). Proc AACR and ASCO 21:1980 (in press).

    Google Scholar 

  98. Moore TN, Livingston R, Heilbrun L et al.: An acceptable rate of complications in combined doxorubicin-irradiation for small cell carcinoma of the lung: A Southwest Oncology Group study. Int J Radiat Oncol Biol Phys 4:675–680, 1978.

    PubMed  CAS  Google Scholar 

  99. Chabora BM, Hopfan S, Wittes R: Esophageal complications in the treatment of oat cell carcinoma with combined irradiation and chemotherapy. Radiology 123:185–187, 1977.

    PubMed  CAS  Google Scholar 

  100. Einhorn L, Krause M, Hornback N et al.: Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer. Cancer 37:2414–2416, 1976.

    PubMed  CAS  Google Scholar 

  101. Von Hoff DD, Layard MW, Basa P et al.: Risk factors for doxorubicin-induced congestive heart failure. Ann Int Med 91:710–717, 1979.

    Google Scholar 

  102. Seydel HG, Creech RH, Mietlowski W et al.: Radiation therapy in small cell lung cancer. Semin Oncol 5:288–298, 1978.

    PubMed  CAS  Google Scholar 

  103. Abrams RA, Lichter A, Johnston-Early A et al.: Enhanced suppression of peripheral blood CFUC and white blood cell and platelet counts by regional radiotherapy in adult patients with non-hemotologic malignancy. Proc AACR and ASCO 20:144, 1979.

    Google Scholar 

  104. Hirsch FR, Hansen HH, Paulson OB et al.: Development of brain metastases in small cell anaplastic carcinoma of the lung. In: CNS Complications of Malignant Disease. Kay J, Whitehouse J (eds), MacMillan Press, 1979, p 175-184.

    Google Scholar 

  105. Newman SJ, Hansen HH: Frequency, diagnosis and treatment of brain metastases in 247 consecutive patients with bronchogenic carcinoma. Cancer 33:492–496, 1974.

    PubMed  CAS  Google Scholar 

  106. Hansen HH: Should initial treatment of small cell carcinoma include systemic chemotherapy and brain irradiation? Cancer Chemother Rep (Part 3) 4(2):239–241, 1973.

    CAS  Google Scholar 

  107. Cox JD, Petrovich Z, Paig C et al.: Prophylactic cranial irradiation in patients with inoperable carcinoma of the lung. Cancer 42:1135–1140, 1978.

    PubMed  CAS  Google Scholar 

  108. Bunn PA, Nugent JL, Matthews MJ: Central nervous system metastases in small cell bronchogenic carcinoma. Semin Oncol 5:314–322, 1978.

    PubMed  Google Scholar 

  109. Brereton HD, O’Donnell JF, Kent CH et al.: Spinal meningeal carcinomatosis in small-cell carcinoma of the lung. Ann Intern Med 88:517–519, 1978.

    PubMed  CAS  Google Scholar 

  110. Greco FA, Fer MF: Oat-cell carcinoma of the lung with carcinomatous meningitis. N Engl J Med 298:1146, 1978.

    PubMed  CAS  Google Scholar 

  111. Fox RM: Spinal cord metastasis after combination chemotherapy and prophylactic whole-brain irradiation in small cell carcinoma of the lung. Lancet 2:136, 1977.

    PubMed  CAS  Google Scholar 

  112. Minna JD, Ihde DC, Bunn PA et al.: Extensive stage small cell carcinoma of the lung (SCCL): Effect of increasing intensity of induction chemotherapy. Proc AACR and ASCO, 1980 (in press).

    Google Scholar 

  113. Weidin PL. Storb R, Seeg HJ et al.: Prolonged disease-free survival in dogs with lymphoma after total body irradiation and autologous marrow transplantation consolidation of combination chemotherapy induced remissions. Blood 54:1039–1049, 1979.

    Google Scholar 

  114. Thomas ED, Buchner CD, Fefer A et al.: Marrow transplantation for acute nonlymphoblas-tic leukemia in first remission. N Engl J Med 301:597–599, 1979.

    PubMed  CAS  Google Scholar 

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Authors
  1. Paul A. Bunn Jr.
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  2. Daniel C. Ihde
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Editors and Affiliations

  1. Cleveland Clinic, Cleveland, Ohio, 44106, USA

    R. B. Livingston

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© 1981 Martinus Nijhoff Publishers bv, The Hague

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Bunn, P.A., Ihde, D.C. (1981). Small Cell Bronchogenic Carcinoma: A Review of Therapeutic Results. In: Livingston, R.B. (eds) Lung Cancer 1. Cancer Treatment and Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8207-9_8

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  • DOI: https://doi.org/10.1007/978-94-009-8207-9_8

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