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The role of animal models in the study of experimental metastasis

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Tumor Invasion and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 7))

Abstract

Metastasis is a dynamic process that occurs in vivo and, therefore, studies of cancer metastasis must logically include data from in vivo experiments and observations. Failure to consider these in vivo data can result in the investigation of irrelevant, albeit fascinating, epiphenomena of in vitro systems. Identification of the tumor cell or host characteristics that are important for metastatic dissemination can only be made when there are strong correlations between possession of, or alterations in, the observed phenotype and changes in the in vivo behavior of that tumor in the appropriate host. All too often investigators have proposed that particular alterations or modifications in cellular properties are responsible for differences in metastatic behavior without first verifying that the cells under investigation were indeed capable of metastasis [1].

Research sponsored by the National Cancer Institute, DHHS, under Contract No. N01-C0-75380 with Litton Bionetics, Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

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  1. I. R. Hart
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Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    L. A. Liotta

  2. Frederick Cancer Research Center, Frederick, Maryland, USA

    I. R. Hart

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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London

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Hart, I.R. (1982). The role of animal models in the study of experimental metastasis. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_1

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  • DOI: https://doi.org/10.1007/978-94-009-7511-8_1

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