Abstract
In recent years attention has focused on the potential for the development of adverse sequelae of central nervous system preventive therapy in children with acute lymphoblastic leukemia. Anatomic abnormalities (defined by CT brain scan), neuroendocrine damage, as well as neurological and intellectual dysfunction have all been reported in patients who have received central nervous system propylaxis, usually in the form of cranial radiation and intrathecal chemotherapy. In the late 1970’s the Pediatric Oncology Branch of the National Cancer Institute embarked on a series of studies designed to characterize the adverse sequelae associated with CNS prophylaxis (1–3). The present report will summarize the findings of these studies and discuss their implications for the treatment of the patient with ALL.
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References
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© 1983 Martinus Nijhoff Publishers, Boston
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Poplack, D.G. (1983). Evaluation of Adverse Sequelae of Central Nervous System Prophylaxis in Acute Lymphoblastic Leukemia. In: Mastrangelo, R., Poplack, D.G., Riccardi, R. (eds) Central Nervous System Leukemia. Developments in Oncology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6708-3_11
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DOI: https://doi.org/10.1007/978-94-009-6708-3_11
Publisher Name: Springer, Dordrecht
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