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Biosynthesis of Carotenoids

  • Chapter
The Biochemistry of the Carotenoids

Abstract

Carotenoids, being terpenoids, are synthesized from the basic C5 terpenoid precursor, isopentenyl pyrophosphate (IPP). The first part of the chapter is concerned with evidence for IPP formation in higher plants and carotenogenic micro-organisms and for its conversion into geranylgeranyl pyrophosphate (GGPP), the C20 precursor of phytoene, the first C40 hydrocarbon formed. Then the formation of phytoene is discussed followed by a full description of its conversion into lycopene. Finally, the conversion of lycopene and related compounds, such as neurosporene, into the various naturally occurring carotenes and xanthophylls is described. This should allow the reader to follow more easily specialized aspects of biosynthesis, such as intracellular location of synthesis and photoinduction of synthesis, in the appropriate chapters which follow.

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References

  1. Schopfer, W. H. & Grob, E. C. (1950), Experientia 6, 419.

    Google Scholar 

  2. Schopfer, W. H. & Grob, E. C. (1952), Experientia 8, 140.

    Google Scholar 

  3. Schopfer, W. H., Grob, E. C, Besson, G. & Keller V. (1952), Arch. Sci., Geneva 5, 1.

    Google Scholar 

  4. Schopfer, W. H., Grob, E. C. & Besson, G. (1952), Arch. Sci., Geneva 5, 5.

    Google Scholar 

  5. Grob, E. C. & Bütler, R. (1955), Helv. chim. Acta 38, 1313.

    Google Scholar 

  6. Grob, E. C. & Bütler, R. (1956), Heb. chim. Acta 39, 1975.

    Google Scholar 

  7. Braithwaite, G. D. & Goodwin, T. W. (1960), Biochem. J. 76, 1.

    Google Scholar 

  8. Braithwaite, G. D. & Goodwin, T. W. (1960), Biochem. J. 76, 5.

    Google Scholar 

  9. Braithwaite, G. D. & Goodwin, T. W. (1960), Biochem. J. 76, 194.

    Google Scholar 

  10. Steele, W. J. & Gurin, S. (1960), J. biol. Chem. 235, 2778.

    Google Scholar 

  11. Lotspeich, F. J., Krause, R. F., Lilly, V. G. & Barnett, H. L. (1959), J. biol. Chem. 234, 3109.

    Google Scholar 

  12. Eberle, M. & Arigoni, D. (1969), Helv. chim. Acta 43, 1508.

    Google Scholar 

  13. Tavormina, P. A., Gibbs, M. H. & Huff, J. W. (1956), J. Am. chem. Soc. 78, 4498.

    Google Scholar 

  14. Chichester, C. O., Nakayama, T. O. M., Lukton, A. & Mackinney, G. (1959), J. biol. Chem. 234, 598.

    Google Scholar 

  15. Yokoyama, H., Chichester, C. O. & Mackinney, G. (1960). Nature 185, 687.

    Google Scholar 

  16. Grob, E. C. (1959), In Biosynthesis of Terpenes and Sterols (ed. G. E. W. Wolstenholme & M. O’Connor), p. 267, London: Churchill.

    Google Scholar 

  17. Anderson, D. G., Norgard, D. W. & Porter, J. W. (1960), Archs Biochem. Biophys. 88, 68.

    Google Scholar 

  18. Krzeminski, L. F. & Quackenbush, F. W. (1960), Archs Biochem. Biophys. 88, 267.

    Google Scholar 

  19. Goodwin, T. W. (1959), in Biosynthesis of Terpenes and Sterols (ed. G. E. W. Wolstenholme & M. O’Connor), p. 279, London: Churchill.

    Google Scholar 

  20. Schneour, E. & Zabin, I. (1959), J. biol. Chem. 234, 770.

    Google Scholar 

  21. Purcell, A. E., Thompson, G. A. & Bonner, J. (1959), J. biol. Chem. 234, 1081.

    Google Scholar 

  22. Suzue, G. (1960), Biochim. biophys. Acta 45, 88; 616, 180.

    Google Scholar 

  23. Threlfall, D. R. (1963) quoted by Goodwin, T. W. (1971), in Carotenoids (ed. O. Isler), p. 577, Basel: Birkhäuser.

    Google Scholar 

  24. Goodwin, T. W. (1958), Biochem. J. 70, 612.

    Google Scholar 

  25. Goodwin, T. W. & Mercer, E. I. (1963), in Control of Lipid Metabolism (ed. J. K. Grant), Biochem. Soc. Symp. No. 24, p. 37, London: Academic Press.

    Google Scholar 

  26. Treharne, K. J., Mercer, E. I. & Goodwin, T. W. (1966), Biochem. J. 99, 239.

    Google Scholar 

  27. Rudney, H., Stewart, P. R., Majerus, P. W. & Vagelos, P. R. (1966), J. biol. Chem. 241, 1226.

    Google Scholar 

  28. Middleton, B. & Tubbs, P. K. (1972), Biochem. J. 126, 27.

    Google Scholar 

  29. Brooker, J. D. & Russell, D. W. (1975), Archs Biochem. Biophys. 167, 730, 737.

    Google Scholar 

  30. Bach, T. J., Lichtenthaler, H. K. & Retey, J. (1976), Abst. Symp. Lipids in Plants, Karlsruhe, p. 96.

    Google Scholar 

  31. Gross, J. A., Britton, G. & Goodwin, T. W. (1974) (unpublished observations).

    Google Scholar 

  32. Hepper, C. M. & Audley, B. A. (1969), Biochem. J. 114, 379.

    Google Scholar 

  33. Goodwin, T. W. & Lijinsky, W. (1952), Biochem. J. 50, 268.

    Google Scholar 

  34. Coon, M. J., Kupiecki, F. P., Dekker, E. E., Schlesinger, M. J. & del Campillo, A. (1959), in Biosynthesis of Terpenes and Sterols (ed. G. E. W. Wolstenholme & M. O’Connor), p. 62, London: Churchill.

    Google Scholar 

  35. Wuhrmann, J. J., Yokoyama, H. & Chichester, C. O. (1957), J. Am. chem. Soc. 79, 4569.

    Google Scholar 

  36. Yamamoto, H. Y., Chichester, C. O. & Nakayama, T. O. M. (1962), Archs Biochem. Biophys. 97, 645.

    Google Scholar 

  37. Yamamoto, H. Y., Nakayama, T. O. M. & Chichester, C. O. (1962), Archs Biochem. Biophys. 96, 168.

    Google Scholar 

  38. Yamamoto, H. Y., Chichester, C. O. & Nakayama, T. O. M. (1962), Photochem. Photobiol. 1, 53.

    Google Scholar 

  39. Yamamoto, H. Y. & Chichester. C. O. (1965), Biochim. biophys. Acta 109, 303.

    Google Scholar 

  40. Yokoyama, H., Chichester, C. O., Nakayama, T. O. M., Lukton, A. & Mackinney, G. (1957), J. Am. chem. Soc. 79, 2029.

    Google Scholar 

  41. Ehrenberg, L. & Faludi-Daniel, A. (1962), Acta Chem. Scand. 16, 1523.

    Google Scholar 

  42. Goodwin, T. W. & Osman, H. G. (1953), Archs Biochem. Biophys. 47, 215.

    Google Scholar 

  43. Starr, M. P. & Saperstein, S. (1953), Archs Biochem. Biophys. 43, 157.

    Google Scholar 

  44. Arnaki, M. & Stary, Z. (1952), Biochem. Z.323, 376.

    Google Scholar 

  45. Ishii, R. (1952), J. Ferment. Technol. (Japan) 30, 350.

    Google Scholar 

  46. Ishii, R. (1952), J. Ferment. Technol. (Japan) 30, 390.

    Google Scholar 

  47. Reichel, L. & Wallis, M. (1957), Naturwissenschaften 44, 234.

    Google Scholar 

  48. Loomis, W. D. & Battaile, J. (1963), Biochim. biophys. Acta 67, 54.

    Google Scholar 

  49. Valenzuela, P., Beytia, E., Cori, O. & Yudelevich, A. (1966), Archs Biochem. Biophys. 113, 336.

    Google Scholar 

  50. Garcia-Peregrin, E., Suarez, M. D. & Mayor, F. (1973), FEBS Letters 38, 15.

    Google Scholar 

  51. Gray, J. C. & Kekwick, R. G. O. (1972), Biochim. biophys. Acta 279, 290.

    Google Scholar 

  52. Thomas, D. R. & Stobart, A. K. (1970), Phytochem. 9, 1443.

    Google Scholar 

  53. Archer, B. L., Audley, B. G., Cockbain, E. G. & McSweeney, G. P. (1963), Biochem. J. 89, 565.

    Google Scholar 

  54. Williamson, I. P. & Kekwick, R. G. O. (1975), Biochem. J. 96, 862.

    Google Scholar 

  55. Pollard, C. J., Bonner, J., Haagen-Smit, A. J. & Nimmo, C. C. (1966), Plant Physiol. 41, 66.

    Google Scholar 

  56. Rogers, L. J., Shah, S. P. J. & Goodwin, T. W. (1965), Biochem. J. 113, 37P.

    Google Scholar 

  57. Potty, V. H. & Bruemmer, J. H. (1970), Phytochem. 9, 1443.

    Google Scholar 

  58. Gray, J. C. & Kekwick, R. G. O. (1973), Biochem. J. 133, 335.

    Google Scholar 

  59. Chnoki, S., Suzue, G. & Tanaka, S. (1962), J. Biochem. (Tokyo) 52, 423.

    Google Scholar 

  60. Bloch, K., Chaykin, S., Phillips, A. H. & de Waard, A. (1959), J. biol. Chem. 234, 2595.

    Google Scholar 

  61. Chaykin, S., Law, J., Phillips, A. H., Tchen, T. T. & Bloch, K. (1958), Proc. Nat. Acad. Sci. (U.S.A.) 44, 998.

    Google Scholar 

  62. Lynen, F., Eggerer, J., Henning, U. & Kessel, I. (1958), Angew Chem. 70, 738.

    Google Scholar 

  63. Suzue, G. (1964), Bull. Chem. Soc. (Japan) 37, 615.

    Google Scholar 

  64. Garcia-Peregrin, E., Suarez, M. D., Aragon, M. C. & Mayor, F. (1972), Phytochem. 11, 2495.

    Google Scholar 

  65. de Waard, A., Phillips, A. H. & Bloch, K. (1959), J. Am. chem. Soc. 81, 2913.

    Google Scholar 

  66. Skilleter, D. N. & Kekwick, R. G. O. (1968), Biochem. J. 108, 11.

    Google Scholar 

  67. Varma, T. N. R. & Chichester, C. O. (1962), Archs Biochem. Biophys. 96, 265.

    Google Scholar 

  68. Porter, J. W. (1969), Pure Appl. Chem. 20, 449.

    Google Scholar 

  69. Jungalwala, F. B. & Porter, J. W. (1967), Archs Biochem. Biophys. 127, 209.

    Google Scholar 

  70. Shah, D. V., Feldbrügge, D. H., Houser, A. R. & Porter, J. W. (1968), Archs Biochem. Biophys. 127, 124.

    Google Scholar 

  71. Lee, T.-C. & Chichester, C. O. (1969), Phytochem. 8, 603.

    Google Scholar 

  72. Lee, T-C, Lee, T. H. & Chichester, C. O. (1972), Phytochem. 11, 681.

    Google Scholar 

  73. Harding, R. W., Spurgeon, S. L. & Turner, R. V. (1978), Abst. 5th Symp. Carotenoids p. 20.

    Google Scholar 

  74. Agranoff, B. W., Eggerer, H., Henning, U. & Lynen, F. (1960), J. biol. Chem. 235, 326.

    Google Scholar 

  75. Shah, D. H., Cleland, W. W. & Porter, J. W. (1965), J. biol. Chem. 240, 1926.

    Google Scholar 

  76. Agranoff, B. W., Eggerer, H., Henning, U. & Lynen, F. (1959), J. Am. chem. Soc. 81, 1254.

    Google Scholar 

  77. Dorsey, J. K., Dorsey, J. A. & Porter, J. W. (1966), J. biol. Chem. 241, 5353.

    Google Scholar 

  78. Holloway, P. W. & Popjäk, G. (1967), Biochem. J. 104, 57.

    Google Scholar 

  79. Lynen, F., Eggerer, H., Henning, U. & Kessel, I. (1958), Angew. Chem. 70, 738.

    Google Scholar 

  80. Kandutsch, A. A., Paulus, H., Levin, E. & Bloch, K. (1964), J. biol. Chem. 239, 2507.

    Google Scholar 

  81. Lynen, F., Agranoff, B. W., Eggerer, H., Henning, U. & Moslein, E. M. (1959), Angew. Chem. 71, 657.

    Google Scholar 

  82. Goodman, de W. S. & Popják, G. (1960), J. Lipid Res. 1, 286.

    Google Scholar 

  83. Popják, G. (1959), Tetrahedron Letters, p. 19.

    Google Scholar 

  84. Ogura, K., Koyama, T. & Seto, S. (1969), Biochem. Biophys. Res. Commun. 35, 875.

    Google Scholar 

  85. Green, T. R. & West, C. A. (1974), Biochemistry 13, 4720.

    Google Scholar 

  86. Grob, E. C, Kirschner, K. & Lynen, F. (1961), Chimia (Switz.) 15, 308.

    Google Scholar 

  87. Nandi, D. L. & Porter, J. W. (1964), Archs Biochem. Biophys. 105, 7.

    Google Scholar 

  88. Ogura, K., Shinka, T. & Seto, S. (1972), J. Biochem. (Tokyo) 72, 1101.

    Google Scholar 

  89. Oster, M. & West, C. A. (1968), Archs Biochem. Biophys. 127, 112.

    Google Scholar 

  90. Varma, T. N. R. & Chichester, C. O. (1962), Archs Biochem. Biophys. 96, 419.

    Google Scholar 

  91. Ogura, K., Sagami, H., Seto, S. & Kurokawa, T. (1978), Abst. 5th Symp. Carotenoids p. 45.

    Google Scholar 

  92. Ogura, K., Nishino, T., Koyama, I. & Seto, S. (1971), Phytochem. 10, 779.

    Google Scholar 

  93. Yokoyama, H., Nakayama, T. O. M. & Chichester, C. O. (1962), J. biol. Chem. 237, 681.

    Google Scholar 

  94. Beeler, D. A., Anderson, D. G. & Porter, J. W. (1963), Archs Biochem. Biophys. 102, 26.

    Google Scholar 

  95. Beeler, D. A., & Porter, J. W. (1963), Archs Biochem. Biophys. 100, 167.

    Google Scholar 

  96. Buggy, M. J., Britton, G. & Goodwin, T. W. (1974), Phytochem. 13, 125.

    Google Scholar 

  97. Popják, G. & Cornforth, J. W. (1966), Biochem. J. 101, 553.

    Google Scholar 

  98. Muscio, F., Carlson, J. P., Kuehl, L. & Rilling, H. C. (1974), J. biol. Chem. 249, 3746.

    Google Scholar 

  99. Charlton, J. M., Treharne, K. J. & Goodwin, T. W. (1967), Biochem. J. 105, 205.

    Google Scholar 

  100. Graebe, J. E. (1968), Phytochem. 7, 2003.

    Google Scholar 

  101. Maudinas, B., Bucholtz, M. L. & Porter, J. W. (1975), Abst. 4th Int. Symp. Carotenoids, Berne, p. 41.

    Google Scholar 

  102. Rilling, H. C. (1962), Biochim. biophys. Acta 65, 156.

    Google Scholar 

  103. Gregonis, D. E. & Rilling, H. C. (1974), Biochemistry N.Y. 13, 1538.

    Google Scholar 

  104. Claes, H. (1954), Z. Naturf. B9, 461.

    Google Scholar 

  105. Kessler, E. & Czygan, F. C. (1966), Arch. Mikrobiol. 54, 37.

    Google Scholar 

  106. Haxo, F. (1956), Fort. Chem. Org. Naturst. 12, 169.

    Google Scholar 

  107. Griffiths, M. & Stanier, R. Y. (1956), J. gen. Microbiol. 14, 698.

    Google Scholar 

  108. Meissner, G. & Delbrück, M. (1968), Plant Physiol 43, 1279.

    Google Scholar 

  109. Goodwin, T. W. (1971), in Carotenoids (ed. O. Isler), p. 577. Basel: Birkhäuser.

    Google Scholar 

  110. Davies, B. H., Jones, D. & Goodwin, T. W. (1963), Biochem. J. 87, 317.

    Google Scholar 

  111. Bartels, P. G. & McCullough, C. (1972), Biochem. biophys. Res. Commun. 48,16.

    Google Scholar 

  112. Kleinig, H. (1974), Archs Microbiol 97, 217.

    Google Scholar 

  113. Kümmel, H. W. & Grimme, L. H. (1975), Z. Naturf. 30C, 333.

    Google Scholar 

  114. Altmann, L. J., Ash, I., Kowerski, R. C, Epstein, W. W., Larson, B. R., Rilling, H. C, Muscio, F. & Gregonis, D. E. (1972), J. Am. chem. Soc. 94, 3257.

    Google Scholar 

  115. Qureshi, A. A., Barnes, F. J., Semmler, E. J. & Porter, J. W. (1973), J. biol Chem. 248, 2755.

    Google Scholar 

  116. Beytia, E., Qureshi, A. A. & Porter, J. W. (1973), J. biol Chem. 248, 1856.

    Google Scholar 

  117. Maudinas, B., Bucholtz, M. L., Papastephanou, C, Katiya, S. S., Briedis, A. V. & Porter, J. W. (1975), Biochem. biophys. Res. Commun. 66, 430.

    Google Scholar 

  118. Goodwin, T. W. (1973), Essays in Biochemistry 9, 103.

    Google Scholar 

  119. Cornforth, J. W. & Cornforth, R. H. (1970), Biochem. Soc. Symp. 29, 5.

    Google Scholar 

  120. Cornforth, J. W. & Ross, F. P. (1970), Chem. Comm. 1395.

    Google Scholar 

  121. Goodwin, T. W. & Williams, R. J. H. (1965), Proc. Roy. Soc. 163B, 515.

    Google Scholar 

  122. Cornforth, J. W., Clifford, K., Mallaby, R. & Phillips, G. T. (1972), Proc. Roy. Soc. 182B, 277.

    Google Scholar 

  123. Aung Than, Bramley, P. M., Davies, B. H. & Rees, A. F. (1972), Phytochem. 11, 3187.

    Google Scholar 

  124. Jungalwala, F. B. & Porter, J. W. (1965), Archs Biochem. Biophys. 110, 291.

    Google Scholar 

  125. Herber, R., Maudinas, B., Villoutreix, J. & Granger, P. (1972), Biochim. biophys. Acta 280, 194.

    Google Scholar 

  126. Maudinas, B., Herber, R. & Villoutreix, J. (1974), Biochim. biophys. Acta 348, 357.

    Google Scholar 

  127. Britton, G., Singh, R., Goodwin, T. W. & Ben Aziz, A. (1975), Phytochem. 14, 2427.

    Google Scholar 

  128. Khan, N., Loeber, D. E., Toube, T. P. & Weedon, B. C. L. (1975), J. Chem. Soc. Perkin I, 1457.

    Google Scholar 

  129. Kushwaha, S. C, Pugh, E. L., Cramer, J. K. G. & Kates, M. (1972), Biochim. biophys. Acta 260, 492.

    Google Scholar 

  130. Kushwaha, S. C, Kates, M. & Porter, J. W. (1976), Can. J. Biochem. 54, 816.

    Google Scholar 

  131. Gregonis, D. E. & Rilling, H. C. (1973), Biochem. biophys. Res. Commun. 54, 449.

    Google Scholar 

  132. Brown, D. J., Britton, G. & Goodwin, T. W. (1975), Biochem. Soc. Trans. 3, 741.

    Google Scholar 

  133. Villoutreix, J., Granger, P. & Herber, R. (1978), Abst. 5th Symp. Carotenoids p. 64.

    Google Scholar 

  134. Powls, R. & Britton, G. (1977), Phytochem. 16, 1253.

    Google Scholar 

  135. Williams, R. J. H., Britton, G., Charlton, J. M. & Goodwin, T. W. (1969), Biochem. J. 104, 767.

    Google Scholar 

  136. Buggy, M. J., Britton, G. & Goodwin, T. W. (1969), Biochem. J. 114, 641.

    Google Scholar 

  137. Popjak, G., Edmond, J. & Wong, S-M. (1973), J. Am. chem. Soc. 95, 2713.

    Google Scholar 

  138. Porter, J. W. & Lincoln, R. E. (1950), Archs Biochem. Biophys. 27, 390.

    Google Scholar 

  139. Davies, B. H. (1970), Biochem. J. 116, 93.

    Google Scholar 

  140. Schmidt, K. & Liaaen-Jensen, S. (1973), Acta Chem. Scand. 27, 3040.

    Google Scholar 

  141. Malhotra, H. C, Britton, G. & Goodwin, T. W. (1970), Chem. Comm. 127.

    Google Scholar 

  142. Malhotra, H. C, Britton, G. & Goodwin, T. W. (1970), Int. Z. Vitaminsforsch. 40, 315.

    Google Scholar 

  143. Andrewes, A. G. (1969), Ph.D. Thesis. New Mexico University, Las Cruces.

    Google Scholar 

  144. Weeks, O. B. (1971), in Aspects of Terpenoid Chemistry and Biochemistry (ed. T. W. Goodwin), p. 302, London: Academic Press.

    Google Scholar 

  145. Davies, B. H., Hallett, C. J., London, R. A. & Rees, A. F. (1974), Phytochem. 13, 1209.

    Google Scholar 

  146. Davies, B. H. & Rees, A. F. (1973), Phytochem. 12, 2745.

    Google Scholar 

  147. Goodwin, T. W. & Osman, H. G. (1954), Biochem. J. 56, 220.

    Google Scholar 

  148. Liaaen-Jensen, S., Cohen-Bazire, G., Nakayama, T. O. M. & Stanier, R. M. (1958), Biochim. biophys. Acta 29, 477.

    Google Scholar 

  149. Villoutreix, J. (1960), Biochim. biophys. Acta 40, 434.

    Google Scholar 

  150. Beeler, D. A. & Porter, J. (1963), Archs Biochem. Biophys. 100, 167.

    Google Scholar 

  151. Davies, B. H., Villoutreix, J., Williams, R. J. H. & Goodwin, T. W. (1963), Biochem. J. 89, 96.

    Google Scholar 

  152. Nusbaum-Cassuto, E., Villoutreix, J. & Malenge, J.-P. (1967), Biochim. biophys. Acta 136, 459.

    Google Scholar 

  153. Harding, R. W., Huang, P. C. & Mitchell, H. K. (1969), Archs Biochem. Biophys. 129, 696.

    Google Scholar 

  154. Purcell, A. E., Thompson, G. A. & Bonner, J. (1959), J. biol. Chem. 234, 1081.

    Google Scholar 

  155. Krzeminski, L. F. & Quackenbush, F. H. (1960), Archs Biochem. Biophys. 88, 287.

    Google Scholar 

  156. Yokoyama, H., Nakayama, T. O. M. & Chichester, C. O. (1961), J. biol. Chem. 237, 681.

    Google Scholar 

  157. Purcell, A. E. (1964), Archs Biochem. Biophys. 61, 111.

    Google Scholar 

  158. Karunakaran, A., Karunakaran, M. & Quackenbush, F. W. (1966), Archs Biochem. Biophys. 114, 326.

    Google Scholar 

  159. Kushwaha, S. C, Suzue, G., Subbarayan, G. & Porter, J. W. (1970), J. biol. Chem. 245, 4708.

    Google Scholar 

  160. Papastephanou, C, Barnes, F. J., Briedis, A. V. & Porter, J. W. (1973), Archs Biochem. Biophys. 157, 415.

    Google Scholar 

  161. Qureshi, A. A., Andrewes, A. G., Qureshi, N. & Porter, J. W. (1974), Archs Biochem. Biophys. 162, 93.

    Google Scholar 

  162. Qureshi, A. A., Kim, M., Qureshi, N. & Porter, J. W. (1974), Archs Biochem. Biophys. 162, 108.

    Google Scholar 

  163. Davies, B. H. & Taylor, R. F. (1976), Pure Appl. Chem. 47, 211.

    Google Scholar 

  164. Qureshi, A. A., Qureshi, N., Kim, M. & Porter, J. W. (1974), Archs Biochem. Biophys. 162, 117.

    Google Scholar 

  165. de la Guardia, M. D., Aragon, C. M. G., Murillo, F. J. & Cerdá-Olmedo, E. (1971), Proc. Nat. Acad. Sci. (U.S.A.) 68, 2012.

    Google Scholar 

  166. Aragon, M. G., Murillo, F. J., de la Guardia, M. D. & Cerdá-Olmedo, E. (1976), Eur. J. Biochem. 63, 71.

    Google Scholar 

  167. Eslava, A. P. & Cerdá-Olmedo, E. (1974), Plant Sci. Lett. 2, 9.

    Google Scholar 

  168. Hsu, W-J., Ailion, D. C. & Delbrück, M. (1974), Phytochem. 13, 1463.

    Google Scholar 

  169. Garben, E. D., Baird, M. L., Chapman, D. J. & Howard, D. (1975), Abst. 4th Int. Symp. Carotenoids, Berne p. 17.

    Google Scholar 

  170. Williams, R. J. H., Charlton, J. M„ Britton, G. & Goodwin, T. W. (1967), Biochem. J. 104, 767.

    Google Scholar 

  171. Green, T. R. & Baisted, D. J. (1972), Biochem. J. 130, 983.

    Google Scholar 

  172. Goad, L. J. (1970), Biochem. Soc. Symp. 29, 45.

    Google Scholar 

  173. West, C. A., Dudley, M. W. & Dueber, M. T. (1979), Recent Adv. Phytochem. 13 (in press).

    Google Scholar 

  174. Vose, J. R., Britton, G. & Goodwin, T. W. (unpublished results).

    Google Scholar 

  175. McDermott, J. C. B., Britton, G. & Goodwin, T. W. (1973), Biochem. J. 134, 1115.

    Google Scholar 

  176. Arpin, N., Fiasson, J.-L., Dangye-Caye, M. P., Francis, G. W. & Liaaen-Jensen, S. (1971), Phytochem. 10, 1595.

    Google Scholar 

  177. Hill, H. M., Calderwood, S. K. & Rogers, L. J. (1971), Phytochem. 10, 2051.

    Google Scholar 

  178. Davies, B. H. (1973), Pure Appl. Chem. 35, 1.

    Google Scholar 

  179. Brown, D. J., Britton, G. & Goodwin, T. W. (1975) (unpublished observations).

    Google Scholar 

  180. Meissner, G. & Delbrück, M. (1968), Plant Physiol. 43, 1279.

    Google Scholar 

  181. Tomes, M. L., Quackenbush, F. W. & Kargl, T. E. (1957), Bot Gaz. 117, 248.

    Google Scholar 

  182. Goodwin, T. W. & Jamikorn, M. (1952), Nature 178, 410.

    Google Scholar 

  183. Tomes, M. L., Quackenbush, F. W. & Kargl, T. E. (1958), Bot. Gaz. 119, 250.

    Google Scholar 

  184. Howes, C. D. & Batra, P. P. (1970), Biochim. biophys. Acta 222, 174.

    Google Scholar 

  185. McDermott, J. C. B., Ben-Aziz, A., Singh, R. K., Britton, G. & Goodwin, T. W. (1973), Pure Appl. Chem. 35, 29.

    Google Scholar 

  186. Batra, P. P., Gleason, R. M. Jr. & Louda, J. W. (1973), Phytochem. 12, 1309.

    Google Scholar 

  187. McDermott, J. C. B., Britton, G. & Goodwin, T. W. (1973), J. Gen. Microbiol. 77, 161.

    Google Scholar 

  188. McDermott, J. C. B., Brown, D. J., Britton, G. & Goodwin, T. W. (1974), Biochem. J. 144, 231.

    Google Scholar 

  189. Kleinig, H. & Reichenbach, H. (1973), Biochim. biophys. Acta 306, 249.

    Google Scholar 

  190. Valadon, L. R. G. & Mummery, R. S. (1974), Microbios. 10A, 97.

    Google Scholar 

  191. Howes, C. D. (1974), Phytochem. 13, 1469.

    Google Scholar 

  192. Kleinig, H. (1974), Archs Microbiol. 97, 217.

    Google Scholar 

  193. Kushwaha, S. C. & Kates, M. (1976), Can. J. Biochem. 54, 824.

    Google Scholar 

  194. Hsieh, L. K., Lee, T-C, Chichester, C. O. & Simpson, K. L. (1974), J. Bad. 118, 385.

    Google Scholar 

  195. Coggins, C. W. Jr., Henning, G. L. & Yokoyama, H. (1970), Science 168, 1589.

    Google Scholar 

  196. Yokoyama, H., Coggins, C. W. Jr. & Henning, G. L. (1971), Phytochem. 10, 138.

    Google Scholar 

  197. Yokoyama, H., de Benedict, C, Coggins, C. W. Jr. & Henning, G. L. (1972), Phytochem. 11, 1721.

    Google Scholar 

  198. Hsu, W. J., Yokoyama, H. & Coggins, C. W. Jr. (1972), Phytochem. 11, 2985.

    Google Scholar 

  199. Elahi, M., Lee, T. H., Simpson, K. L. & Chichester, C. O. (1973), Phytochem. 12, 1633.

    Google Scholar 

  200. Simpson, D. J., Rahman, F. M. M., Buckle, K. A. & Lee, T. H. (1974), Aust. J. Plant Physiol. 6, 135.

    Google Scholar 

  201. Umeda, K., Doi, T., Daito, H. & Hirose, K. (1974), J. Fd. Sci. Tech. (Tokyo) 21, 519.

    Google Scholar 

  202. Hayman, E. P., Chichester, C. O. & Simpson, K. L. (1974), Phytochem. 13, 1123.

    Google Scholar 

  203. Hayman, E. P., Yokoyama, H., Chichester, C. O. & Simpson, K. L. (1974), J. Bact. 120, 1339.

    Google Scholar 

  204. Fortino, J. & Splittstoesser, W. E. (1974), Plant Cell Physiol. 15, 59.

    Google Scholar 

  205. Seyama, N. & Splittstoesser, W. E. (1975), Plant Cell Physiol. 16, 13.

    Google Scholar 

  206. Elahi, M., Glass, R. W., Lee, T-C, Chichester, C. O. & Simpson, K. L. (1975), Phytochem. 14, 133.

    Google Scholar 

  207. Simpson, D. J., Rahman, F. M. M., Buckle, K. A. & Lee, T. H. (1974), Aust. J. Plant Physiol. 1, 135.

    Google Scholar 

  208. Elahi, M., Chichester, C. O. & Simpson, K. L. (1973), Phytochem. 12, 1627.

    Google Scholar 

  209. Ninet, L., Renault, J. & Tissier, R. (1969), Biotech. Bioeng. 11, 1195.

    Google Scholar 

  210. Gerasimova, N. M. & Bekhtereva, M. N. (1970), Mikrobiologiya 39, 616.

    Google Scholar 

  211. Goodwin, T. W. (1972), Progress in Industrial Microbiol. 11, 31.

    Google Scholar 

  212. Gross, J., & Costes, C. (1976), Physiol, veg. 14, 427.

    Google Scholar 

  213. Knypl, J. S. (1969), Naturwissenschaften 56, 572.

    Google Scholar 

  214. Feofilova, E. P., Bekhtereva, M. N. & Zozlova, Y. (1970), Mikrobiologiya 39, 457.

    Google Scholar 

  215. Bartels, P. G. & Watson, C. W. (1978), Abst. 5th Symp. Carotenoids p. 3.

    Google Scholar 

  216. Britton, G., Lockley, W. J. S., Powls, R., Goodwin, T. W. & Heyes, L. M. (1977), Nature 268, 81.

    Google Scholar 

  217. Goodwin, T. W. & Williams, R. J. H. (1965), Biochem. J. 94, 56; 97, 28C.

    Google Scholar 

  218. Williams, R. J. H., Britton, G. & Goodwin, T. W. (1967), Biochem. J. 105, 99.

    Google Scholar 

  219. Tomes, M. L. (1967), Genetics 56, 227.

    Google Scholar 

  220. Kjøsen, H., Arpin, N. & Liaaen-Jensen, S. (1972), Acta Chem. Scand. 26, 3053.

    Google Scholar 

  221. Ben Aziz, A., Britton, G. & Goodwin, T. W. (1972), Phytochem. 12, 2759.

    Google Scholar 

  222. Moshier, S. E. & Chapman, D. J. (1973), Biochem. J. 136, 395.

    Google Scholar 

  223. Liaaen-Jensen, S. (1969), Pure Appl. Chem. 20, 421.

    Google Scholar 

  224. Britton, G. (1971), in Aspects of Terpenoid Chemistry & Biochemistry (ed. T. W. Goodwin), p. 255. London: Academic Press.

    Google Scholar 

  225. Britton, G., Lockley, W. J. S., Patel, N. J., Goodwin, T. W. & Englert, G. (1977), J. Chem. Soc. Chem. Comm. 655.

    Google Scholar 

  226. Andrewes, A. G., Liaaen-Jensen, S. & Borch, G. (1974), Acta Chem. Scand. B28, 737.

    Google Scholar 

  227. Buchecker, R., Eugster, C. H., KJøsen, H. & Liaaen-Jensen, S. (1974), Acta Chem. Scand. B28, 449.

    Google Scholar 

  228. Andrewes, A. G., Liaaen-Jensen, S. & Weeks, O. B. (1975), Proc. 4th Int. Symp. Carotenoids, Berne.

    Google Scholar 

  229. Eugster, C. H., Buchecker, R., Tscharner, C, Uhde, G. & Ohloff, G. (1969), Helv. Chim. Acta 52, 1729.

    Google Scholar 

  230. Buchecker, R. & Eugster, C. H. (1973), Helv. Chim. Acta 56, 1124.

    Google Scholar 

  231. Britton, G., Goodwin, T. W., Lockley, W. J. S., Mundy, A. P., Patel, N. J. & Englert, G. (1979), J. Chem. Soc. Chem. Comm. 27.

    Google Scholar 

  232. Bu’Lock, J. D., Austin, D. J., Snatzke, G. & Hruban. I. (1970), Chem. Comm. p. 255.

    Google Scholar 

  233. Milborrow, B. V. (1975), Phytochem. 14, 123.

    Google Scholar 

  234. Vose, J. R., Britton, G. & Goodwin, T. W. (unpublished observations).

    Google Scholar 

  235. Rabourn, W. J. & Quackenbush, F. W. (1959), Archs Biochem. Biophys. 44, 159.

    Google Scholar 

  236. Goodwin, T. W. & Jamikorn, M. (1952), Nature 170, 104.

    Google Scholar 

  237. Tomes, M. A., Quackenbush, F. W. & Kargl, T. E. (1958), Bot. Gaz. 119, 250.

    Google Scholar 

  238. Raymundo, L. C, Griffiths, A. E. & Simpson, K. L. (1967), Phytochem. 6, 157.

    Google Scholar 

  239. Davies, B. H. (1961), Biochem. J. 80, 48P.

    Google Scholar 

  240. Singh, R. K., Ben-Aziz, A., Britton, G. & Goodwin, T. W. (1973), Biochem. J. 132, 649.

    Google Scholar 

  241. Singh, R. K., Ben-Aziz, A., Britton, G. & Goodwin, T. W. (1977), Biochim. biophys. Acta 488, 473.

    Google Scholar 

  242. Britton, G., Singh, R. K. & Goodwin, T. W. (1977), Biochim. biophys. Acta 488, 475.

    Google Scholar 

  243. Bramley, P. M., Davies, B. H. & Aung Than (1977), Phytochem. 16, 235.

    Google Scholar 

  244. Malhotra, H. C, Britton, G. & Goodwin, T. W. (1970), Phytochem. 9, 2360.

    Google Scholar 

  245. Davies, B. H. (1969), Pure Appl. Chem. 20, 545.

    Google Scholar 

  246. Davies, B. H. (1970), Biochem. J. 116, 101.

    Google Scholar 

  247. Davies, B. H. & Aung Than (1974), Phytochem. 13, 209.

    Google Scholar 

  248. Malhotra, H. C, Britton, G. & Goodwin, T. W. (1970), FEBS Letters 6, 334.

    Google Scholar 

  249. Kelly, M., Norgärd, S. & Liaaen-Jensen, S. (1970), Acta Chem. Scand. 24, 2169.

    Google Scholar 

  250. Borch, G., Norgärd, S. & Liaaen-Jensen, S. (1972), Acta Chem. Scand. 26, 402.

    Google Scholar 

  251. Claes, H. (1959), Z. Naturf. B14, 4.

    Google Scholar 

  252. Claes, H. (1956), Z. Naturf. B11, 260.

    Google Scholar 

  253. Claes, H. (1957), Z. Naturf. B12, 401.

    Google Scholar 

  254. Claes, H. (1958), Z. Naturf. B13, 222.

    Google Scholar 

  255. Grumbach, K. H. (1976), Dissertation, Univ. Karlsruhe.

    Google Scholar 

  256. Britton, G., Lockley, W. J. S., Patel, N. J. & Goodwin, T. W. (1977), FEBS Letters 79, 281.

    Google Scholar 

  257. McDermott, J. C. B., Leuenberger, F. J., Britton, G. & Goodwin, T. W. (unpublished observations).

    Google Scholar 

  258. Goodwin, T. W., Britton, G. & Walton, T. J. (1968), Plant Physiol. 43, S-46.

    Google Scholar 

  259. Buchecker, R., Hamm, P. & Eugster, C. H. (1972), Chimia 26, 134.

    Google Scholar 

  260. Walton, T. J., Britton, G. & Goodwin, T. W. (unpublished observations).

    Google Scholar 

  261. Yamamoto, H. Y., Chichester, C. O. & Nakayama, T. O. M. (1962), Archs Biochem. Biophys. 96, 645.

    Google Scholar 

  262. Britton, G., Singh, R. K., Goodwin, T. W. & Ben-Aziz, A. (1975), Phytochem. 14, 2417.

    Google Scholar 

  263. Braithwaite, G. D. & Goodwin, T. W. (1958), Nature 182, 1304.

    Google Scholar 

  264. Benedict, C. R. & Beckman, L. D. (1964), Plant Physiol. 39, 726.

    Google Scholar 

  265. Singh, R. K., Britton, G. & Goodwin, T. W. (1973), Biochem. J. 136, 413.

    Google Scholar 

  266. van Niel, C. B. (1947), Antonie van Leeuwenhoek J. Microbiol. Serol. 12, 155.

    Google Scholar 

  267. Goodwin, T. W., Land, D. G. & Osman, H. G. (1955), Biochem. J. 59, 491.

    Google Scholar 

  268. Schneour, E. A. (1962), Biochim. biophys. Acta 62, 510; 65, 534.

    Google Scholar 

  269. Aasen, A. J. & Liaaen-Jensen, S. (1967), Acta Chem. Scand. 21, 2185.

    Google Scholar 

  270. Francis, G. W. & Liaaen-Jensen, S. (1970), Acta Chem. Scand. 24, 2705.

    Google Scholar 

  271. Aasen, A. J. & Liaaen-Jensen, S. (1967), Acta Chem. Scand. 21, 970.

    Google Scholar 

  272. Schmidt, K. & Liaaen-Jensen, S. (1973), Acta Chem. Scand. 27, 3040.

    Google Scholar 

  273. Gribanovski-Sassu, O. (1972), Phytochem. 11, 3195.

    Google Scholar 

  274. Yamamoto, H. Y. & Chichester, C. O. (1965), Biochim. biophys. Acta 109, 303.

    Google Scholar 

  275. Yamamoto, H. Y., Chichester, C. O. & Nakayama, T. O. M. (1962), Archs Biochem. Biophys. 96, 645.

    Google Scholar 

  276. Sapozhnikov, D. I., Alkhazor, D. G., Eidel’man, Z. M., Bazhanova, I. V., Lemberg, I. K., Maslova, T. G., Girshin, A. B., Popova, I. A., Saakov, B. C, Povova, O. F. & Shiryaeva, G. A. (1964), Dolk. Akad. Nauk SSR 154, 974.

    Google Scholar 

  277. Siefermann, D. & Yamamoto, H. Y. (1975), Archs Biochem. Biophys. 171, 7a.

    Google Scholar 

  278. Britton, G. & Goodwin, T. W. (1969), Phytochem. 8, 2257.

    Google Scholar 

  279. Weedon, B. C. L. (1970), Rev. Pure Appl. Chem. 20, 51.

    Google Scholar 

  280. Bonaly, R. and Malengé, J. P. (1968), Biochim. biophys. Acta 164, 306.

    Google Scholar 

  281. Kayser, F. & Villoutreix, J. (1961), C. r. Soc. Biol. 155, 1094.

    Google Scholar 

  282. Simpson, K. L., Nakayama, T. O. M. & Chichester, C. O. (1964), Biochem. J. 92, 508.

    Google Scholar 

  283. Tefft, R. E., Goodwin, T. W. & Simpson, K. L. (1970), Biochem. J. 177, 921.

    Google Scholar 

  284. Strain, H. H., Manning, W. M. & Hardin, G. J. (1944), Biol. Bull. 86, 169.

    Google Scholar 

  285. Aitzetmüller, K., Svec, W. A., Katz, J. J. & Strain, H. H. (1968), Chem. Comm. 32.

    Google Scholar 

  286. Nitzsche, H., Egger, K. & Dabbagh, A. G. (1969), Tetrahedron Letters 2999.

    Google Scholar 

  287. Williams, R. J. H., Britton, G. & Goodwin, T. W. (1966), Biochim. biophys. Acta 124, 200.

    Google Scholar 

  288. Clough, J. M. & Pattenden, G. (1979), J. Chem. Soc. Chem. Comm. 616.

    Google Scholar 

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Goodwin, T.W. (1980). Biosynthesis of Carotenoids. In: The Biochemistry of the Carotenoids. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5860-9_2

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