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The Cambridge Experience of Artificial Surfactant

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Physiology of the Fetal and Neonatal Lung

Abstract

We have been treating very premature babies with artificial surfactant in Cambridge (UK) since 1979. In this paper I would like to share our experience and ideas about its prophylactic use.

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References

  1. Enhorning, G. and Robertson, B. (1973). Lung expansion in the premature rabbit fetus after tracheal deposition of surfactant. Pediatrics, 50, 58–66

    Google Scholar 

  2. Adams, F. H., Tower, B., Osher, A., Ikegami, M., Fujiwara, T. and Nozaki, M. (1978); Effects of tracheal instillation of natural surfactant in premature lambs. Pediatr. Res., 12, 841–8

    Article  PubMed  CAS  Google Scholar 

  3. Enhorning, G., Hill, D., Sherwood, G., Cutz, E., Robertson, B. and Bryan, C. (1978). Improved ventilation of prematurely delivered primates following tracheal deposition of surfactant. Am. J. Obstet. Gynecol., 132, 529–36

    PubMed  CAS  Google Scholar 

  4. Cutz, E., Enhorning, G., Robertson, B., Sherwood, W. G. and Hill, D. E. (1978). Hyaline membrane disease. Effect of surfactant prophylaxis on lung morphology in premature primates. Am. J. Pathol., 92, 581–94

    PubMed  CAS  Google Scholar 

  5. Bangham, A. D., Morley, C. J. and Phillips, M. C. (1979). The physical properties of an effective lung surfactant. Biochim. Biophys. Acta, 573, 552–6

    CAS  Google Scholar 

  6. Bangham, A. D., Miller, N. G. A., Davies, R. J., Greenough, A. and Morley, C. J. (1984). Introductory remarks about artificial lung expanding compounds (ALEC). Colloid and Surfaces, 10, 337–47

    Article  CAS  Google Scholar 

  7. Morley, C. J., Bangham, A. D., Miller, N. and Davis, J. A. (1981). Dry artificial surfactant and its effect on very premature babies. Lancet, 1, 64–8

    Article  PubMed  CAS  Google Scholar 

  8. Morley, C. j., Gore, S. M., Greenough, A., Miller, N. G. A., Hill, C. M., Brown, B. D., Pool, J. and Bangham, A. D. (1986). Randomized trial of artificial surfactant at birth. 1. Pragmatic analysis. (In press)

    Google Scholar 

  9. Papile, L. A., Burstein, J., Burstein, R. and Koffler, H. (1978). Incidence and evolution of subependymal and intraventricular haemorrhage. A study of infants with birthweight less than 1500 gm. J. Pediatr., 92, 529–34

    Article  PubMed  CAS  Google Scholar 

  10. Greenough, A., Morley, C. J., Wood, S. and Davis, J. A. (1984). Pancuronium prevents pneumothoraces in ventilated babies who actively expire against positive pressure inflation. Lancet, 1, 1–3

    Article  PubMed  CAS  Google Scholar 

  11. Greenough, A., Morley, C. J. and Johnson, P. (1985). An active expiratory reflex in preterm ventilated infants. In The Physiological Development of the Fetus and Newborn. (New York: Academic Press)

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© 1987 MTP Press Limited

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Morley, C.J. (1987). The Cambridge Experience of Artificial Surfactant. In: Walters, D.V., Strang, L.B., Geubelle, F. (eds) Physiology of the Fetal and Neonatal Lung. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4155-7_18

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  • DOI: https://doi.org/10.1007/978-94-009-4155-7_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8344-7

  • Online ISBN: 978-94-009-4155-7

  • eBook Packages: Springer Book Archive

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