Abstract
The method developed by Ugelstad and coworkers1-3 for preparation of monosized polymer particles allows preparation of particles of any size from 1 to 100 µm with standard deviation in diameter ~ 1%. Also the method allows preparation of particles from a large number of monomers. Particles with highly crosslinked polymer of high mechanical strength, porous macroreticular particles and core and shell particles are prepared. The application of the porous macroreticular particles in fast protein liquid chromatography (FPLC)4 as marketed by Pharmacia is already well established and has in many cases led to very significant improvements in analysis and separation of complex protein mixtures.
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References
Ugelstad J; Mork PC; Kaggerud HK; Ellingsen T and Berge A: Adv. Colloid Interface Sci. 13, 101 (1980).
Ugelstad J; Mfutakamba HR; Mork PC; Ellingsen T; Berge A; Schmid R; Holm L; Jorgedal A; Hansen FK and Nustad K: J. Polym. Sci. 72, 225 (1985).
Ugelstad J; Mork PC; Nordhuus I; Mfutakamba H; Soleimany E; Berge A; Ellingsen T and Khan AA: Makromol. Chem. Suppl. 10/11, 215 (1985).
Ugelstad J; Soderberg L; Berge A and Bergstrom J: Nature 303, 95 (1983).
Nustad K; Johansen L; Ugelstad J; Ellingsen T and Berge A: Eur. Surg. Res. 16, (Suppl. 2), 80 (1984).
Millan JL; Nustad K and Norgaard Pedersen B: Clin. Chim. 31, 54 (1985).
Johansen L; Nustad K; Orstavik TE; Ugelstad J; Berge A and Ellingsen T: J. Immunol. Methods 59, 225 (1983).
Nustad K; Closs O and Ugelstad J: in Developments in Biological Standardization 57 Monoclonal Antibodies: Standardization of their Characterization and Use, p.321 Basel (1984).
Biomag™ Technical Bulletins Advanced Magnetics Inc., Cambridge, Massachusetts U.S.A. (1984)
Rembaum A; Yen SPS and Molday RS: Macromol. Sci. Chem. A13, 603 (1979).
Margel S; Beitler U and Ofarim M: J. Cell. Sci. 56, 157 (1982).
Daniel JC; Schuppiser JL and Tricot M: U.S. Patent 4,358,388 (1982).
Buske N and Goetze T: Acta Polymerica 34, 184 (1983).
Mosbach K and Schroder U: FEBS Lett. 102, 112 (1979).
Schroder U; Stahl A and Salford LG: in “Microspheres and Drug Therapy”, Davis SS (eds). Illum L; McVie JG and Tomlinson E: Elsevier Science Publ. p. 427 (1984).
Schroder U: Methods in Enzymology 112, 116 (1986).
Widder KJ and Senyei AE: In reference 15, p. 393.
Senyei AE; Driscoll CF and Widder KJ: Methods in Enzymology 112, 56 (1986).
Poyn CH; Dicke KA; Culbert S; Frankel LS; Jagannath S and Read CL: Lancet 524 (1983).
Kronick P and Gilpin RW: J. of Biochem. and Biophys. Methods 12, 73 (1980).
Ugelstad J; Ellingsen T; Berge A; Helgee og B: PCT Int. Appl. W083/03920 (1983).
Morup S: DTH, D-2800 Lyngby Denmark, private report.
Fjellvag H and Skjeltorp A: IFE, N-2007 Kjeller Norway. Private report.
Cullity RD: Introduction to Magnetic Materials, Addison Wesley Co. Inc., U.S.A. 1972.
Bagchi P and Birnbaum SM: J. Coll. Interface Sci. 83, 460 (1981).
Nilsson K and Mosbach K: Biochem. Biophys. Res. Commun. 102, 449 (1981).
Danielsen H; Funderud S; Nustad K; Reith A and Ugelstad J: Scand. J. Immunol., 24, 179 (1986).
Treleaven JG; Gibson FM; Ugelstad J; Rembaum A and Kemshead J: Magnetic Separation News 1, 103, (1984).
Treleaven JC; Gibson FM; Ugelstad J; Rembaum A; Philip T; Caine GD and Kemshead JT: Lancet 1, 70 (1984).
Kemshead J; Treleaven JG; Gibson FM; Ugelstad J; Rembaum A and Philip T: in “Advances in Neuroblastoma Research, Progress in Clinical and Biological Research”, 175, p.413. Evans AE; D’Angir GJ; Seeger RC and Liss AK (eds), New York (1985).
Ugelstad J; Rembaum A; Kemshead JT; Nustad K; Funderud S and Schmid R: In reference 15, p.365.
Nustad K; Danielsen H; Reith A; Funderud S; Lea T; Vartdal F and Ugelstad J: in “Microspheres: Medical and Biological Applications”. Rembaum A (ed): CRD Press Inc. in press.
Seeger R; Reynolds CP; Vo DD; Ugelstad J and Wells J: In reference 30, p.443.
Reynolds CP; Seeger R; Vo DD; Black AT; Wells J and Ugelstad J: Cancer Research, 46, 5882 (1986).
Kvalheim G; Fodstad O; Pihl A; Nustad K; Pharo A; Ugelstad J and Funderud S: Cancer Research, 47, 32 (1987).
Lea T; Vartdal F; Davies C and Ugelstad J: Scand. J. Immunol. 22, 207 (1985).
Platsoucas C; Chae FH; Collins N; Kerner N; Laver J; Ellingsen T; Stenstad P; Bjorgum J; Rembaum A; O’Reilly R and Ugelstad J: In reference 32.
Vartdal F; Kvalheim G; Lea TE; Bosnes V; Gaudernack G; Ugelstad J and Albrechtsen D: Transplantation, in press.
Albrechtsen D; Gaudernack G; Kvalheim G; Lea T; Ugelstad J and Vartdal F: Transplantation, Vol. I, 108 (1986).
Gaudernack G; Leivestad T; Ugelstad J and Thorsby E: J. Immunol. Methods 90, 179 (1986).
Lea T; Smeland E; Funderud S; Vartdal F; Davies C; Beiske K and Ugelstad J: Scand. J. Immunol., 23, 509 (1986).
Vartdal F; Gaudernack G; Funderud S; Bratlie A; Lea T; Ugelstad J and Thorsby E: Tissue Antigens 28, 301 (1986).a
Howell K; Ansorge W and Grunberg J: In ref. 15, p.443.
Howell K: EMBL Research Reports p.24 (1984)
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Ugelstad, J. et al. (1987). Biomedical Applications of Monodisperse Magnetic Polymer Particles. In: El-Aasser, M.S., Fitch, R.M. (eds) Future Directions in Polymer Colloids. NATO ASI Series, vol 138. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3685-0_22
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DOI: https://doi.org/10.1007/978-94-009-3685-0_22
Publisher Name: Springer, Dordrecht
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