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The Measurement of Kidney-Derived Immunologically Reactive Material in Urine and Plasma for Studying Renal Integrity

  • Chapter
Nephrotoxicity in the experimental and clinical situation

Part of the book series: Developments in Nephrology ((DINE,volume 19-20))

Abstract

It is the purpose of this chapter to describe the need for sensitive, site-specific immunoassays for identifying renal damage. These tests should complement rather than replace the established assays, both in clinical practice and in assessing the information derived from animal and in vitro studies. In common with all other chemical pathology assays, the interpretation of these data demands a thorough understanding of the pathophysiology of the condition and the methodological factors which can influence results. The advantages and disadvantages of these different methods will be discussed. The chapter deals with the problems of identifying renal-derived material, recent advances in assay development, and outlines the need for future development, in particular noninvasive tests for the detection of acute interstitial nephritis.

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Authors
  1. A. B. St. J. Dawnay
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  2. W. R. Cattell
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Editors and Affiliations

  1. The Robens Institute, University of Surrey, Guildford, Surrey, GU2 5XH, England

    P. H. Bach

  2. Biochemical Toxicology Section, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire, SKI0 4TJ, England

    E. A. Lock

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© 1987 Martinus Nijhoff Publishers

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Dawnay, A.B.S.J., Cattell, W.R. (1987). The Measurement of Kidney-Derived Immunologically Reactive Material in Urine and Plasma for Studying Renal Integrity. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity in the experimental and clinical situation. Developments in Nephrology, vol 19-20. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3371-2_5

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  • DOI: https://doi.org/10.1007/978-94-009-3371-2_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8014-9

  • Online ISBN: 978-94-009-3371-2

  • eBook Packages: Springer Book Archive

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