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Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 12))

Abstract

Among the movement disorders progressive supranuclear palsy (PSP) is a degenerative neurological disease characterized by a loss of voluntary control of vertical gaze, dysarthria, diffuse body rigidity with dystonic extension of the neck and dementia (Steele, 1975).

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References

  • Baron, J.C., Samson, Y., Crouzel, C. et al. 1985b. Pharmacologic studies in man with PET: an investigation using l-labeled ketanserin, a 5-HT2 receptor antagonist. In “Cerebral Blood Flow and Metabolism Measurement”. (Eds. A. Hartmann, S. Hoyer). (Springer, Berlin, Heidelberg, New York), pp. 473–480.

    Google Scholar 

  • Baron, J.C., Comar, D., Zarifian, E. et al. 1985a. Dopaminergic receptor sites in human brain: positron emission tomography. Neurology, 35, 1624.

    Google Scholar 

  • Bokobza, B., Ruberg, M., Scatton, B. et al. 1984. 3H-spiperone binding, dopamine and HVA concentrations in Parkinson’s disease and supranuclear palsy. Eur. J. Pharmacol., 99, 167–175.

    Article  PubMed  CAS  Google Scholar 

  • Crawley, J.C.W., Smith, T., Yeall, N. et al. 1983. Dopamine receptors displayed in human living brain with 77Br-p-bromospiperone. Lancet, II, 975.

    Article  Google Scholar 

  • Farde, L., Ehrin, E., Eriksson, L. et al. 1985. l-labeled dopamine-2-receptor antagonists as tools for quantitative studies or dopamine receptors in the human brain. In “Brain 85”, 16–20 June 1985, Ronneby, Sweden, pp. 205.

    Google Scholar 

  • Friedman, A.M., Dejesus, O.T., Revenaugh, B.A. et al. 1984. Measurements in vivo of parameters of the dopamine system. Ann. Neurol., 15, (Suppl.), 566–576.

    Google Scholar 

  • Frost, J.J., Wagner, H.N., Dannals, R.F. et al. 1985. Imaging opiate receptors in the human brain by positron tomography. J. Comput. Assist. Tomogr., 9, 231–236.

    Article  PubMed  CAS  Google Scholar 

  • Huang, C.C., Friedman, A.M., So, R. et al. 1980. Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug. J. Pharm. Sci., 69, 984–986.

    Article  PubMed  CAS  Google Scholar 

  • Kulmala, H.K., Huang, C.C., Dinerstein, R.J. et al. 1981. Specific in vivo binding of 77-Br-p-bromospiroperidol in rat brain: a potential tool for gamma ray imaging. Life Sci., 28, 1911–1916.

    Article  PubMed  CAS  Google Scholar 

  • Laduron, P.M., Janssen, P.F.M., Leysen, J.E. 1978. Spiperone, a ligand of choice for neuroleptic receptors. 2. Regional distribution and in vivo displacement by neuroleptic drugs. Biochem. Pharmacol., 27, 371–321.

    Google Scholar 

  • Leenders, K.L., Herold, S., Brooks, D.J. et al. 1984. Pre-synaptic and post-synaptic dopaminergic systems in human brain. Lancet, II, 110–111.

    Article  Google Scholar 

  • Mazière, B., Loc’h, C., Hantraye, P. et al. 1984. 76-Br-bromospiperidol: a new tool for quantitative in vivo imaging of neuroleptic receptors. Life Sci., 35, 1349–1356.

    Article  PubMed  Google Scholar 

  • Mazière, B., Loc’h, C., Baron, J.C. et al.1985. In vivo quantitative imaging of dopamine receptors in human brain using positron tomography and 76Br-bromospiperone. Eur. J. Pharmacol., 114, 267–272.

    Article  PubMed  Google Scholar 

  • Mazziotta, J.C., Phelps, M.E., Miller, J. et al. 1981. Tomographic mapping of human cerebral metabolism: normal unstimulated state. Neurology, 31, 503–516.

    Google Scholar 

  • Mintun, M.A., Raichle, M.E., Kilbourn, M.R. et al. 1984. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol., 15, 217–227.

    Article  PubMed  CAS  Google Scholar 

  • Owen, F., Poulter, M., Marshall, R.D. et al. 1983. 77Br-p-bromospiperone: a ligand for in vivo labelling of dopamine receptors. Life Sci., 3, 765–768.

    Article  Google Scholar 

  • Phelps, M.E., Mazziotta, J.U. 1985. Positron emission tomography: human brain function and biochemistry. Science, 228, 799–809.

    Article  PubMed  CAS  Google Scholar 

  • Ruberg, M., Bokobza, B., Javoy-Agid, F. et al. 1984. 3H-spiperone binding in the nigrostriatal system in human brain. Eur. J. Pharmacol., 99, 159–165.

    CAS  Google Scholar 

  • Ruberg, M., Javoy-Agid, F., Hirsch, E. et al. 1985. Aminergic, cholinergic, and gabaergic systems in the brain of patients with progressive supranuclear palsy. Ann. Neurol., 18, 523–529.

    Article  PubMed  CAS  Google Scholar 

  • Samson, Y., Hantraye, P., Baron, J.C. et al. 1985. Kinetics and displacement of 11C-R0 15–1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. Eur. J. Pharmacol., 110, 247–251.

    Article  PubMed  CAS  Google Scholar 

  • Soussaline, F., Campagnolo, R., Verrey, B. et al. 1984. Physical characterization of a time-of-flight positron emission tomography system for wholebody quantitative studies. J. Nucl. Med., 25, P46.

    Google Scholar 

  • Steele, J.C. 1975. Progressive supranuclear palsy. In “Handbook of Neurology”, Vol. 22. (Eds. Vinken, Bruyn). (Elsevier Pubi. Comp.). pp. 217–229.

    Google Scholar 

  • Stoof, J.C. 1983. Dopamine receptors in the neostriatum: Biochemical and physiological studies. In “Dopamine Receptors”. (Eds. C. Kaiser, J.W. Kebabian). (A.C.S. Symposium Series, Vol. 224). pp. 117–145.

    Chapter  Google Scholar 

  • Syrota, A., Paillotin, G., Davy, J.M. et al. 1984. Kinetics of in vivo binding of antagonist to muscarinic cholinergic receptor in the human heart studied by positron emission tomography. Life Sci., 35, 837–845.

    Article  Google Scholar 

  • Wagner, H.N., Burns, H.D., Dannais, R.F. et al. 1983. Imaging dopamine receptors in the human brain by positron tomography. Science, 221, 1264–1266.

    Article  PubMed  CAS  Google Scholar 

  • Wong, D.F., Wagner, H.N., Dannais, R.F. et al. 1984. Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science, 1393–1396.

    Google Scholar 

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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg

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Mazière, B., Baron, J.C., Loc’h, C., Cambon, H., Agid, Y. (1987). Progressive Supranuclear Palsy Studied by Pet. In: Heiss, WD., Pawlik, G., Herholz, K., Wienhard, K. (eds) Clinical efficacy of positron emission tomography. Developments in Nuclear Medicine, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3345-3_9

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  • DOI: https://doi.org/10.1007/978-94-009-3345-3_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8002-6

  • Online ISBN: 978-94-009-3345-3

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