Abstract
Based on experimental data, Siem first suggested in 1886 that the systemic toxicity of aluminum would largely be manifested by disturbances of neuro-logical function [1]. Additional support for this contention was obtained by Doellken in 1897 who demonstrated anatomical alteration in the brains of animals who had received subcutaneous injections of aluminum [2] and Scherp and Church [3] who demonstrated changes resulting from direct injection of aluminum into the brain. These observations led to the use of aluminum to induce an experimental form of epilepsy.
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References
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Alfrey, A.C., Froment, D.C. (1990). Dialysis encephalopathy. In: de Broe, M.E., Coburn, J.W. (eds) Aluminum and renal failure. Developments in Nephrology, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1868-9_19
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DOI: https://doi.org/10.1007/978-94-009-1868-9_19
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