Abstract
The in vitro adherence of lymphocytes to lacrimal gland (LG) tissue was compared to high endothelial venules (HEV) of cervical lymph node (CLN) tissue. Thoracic duct (TDL) and mesenteric lymph node (MLN) lymphocytes bound preferentially over peripheral lymph node (PLN) lymphocytes, while thymocytes (THY) did not bind. Lymphocyte binding to LG was specific for acinar cells (AC). Like CLN-HEV binding, TDL adherence to LG-AC requires viable, metabolically active cells and involves cellular cytoskeleton, surface protein, but not sialic acid. Unlike binding to CLN-HEV, TDL binding to LG-AC does not require divalent cations. The LG-AC interaction involves carbohydrate, but the sugar specificity differs. These findings suggest that the localization of circulating lymphocytes within one glandular tissue (LG) is mediated by a receptor-ligand interaction which differs from that involved in HEV interactions.
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© 1990 Kluwer Academic Publishers
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O’Sullivan, N.L., Montgomery, P.C. (1990). Characterisation of the lymphocyte-glandular mucosal tissue interaction using an in vitro adherence assay. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_63
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DOI: https://doi.org/10.1007/978-94-009-1848-1_63
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