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Morphologic and densitometric quantitation of coronary stenoses; an overview of existing quantitation techniques

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New Developments in Quantitative Coronary Arteriography

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 87))

Summary

Various groups are involved in the development and use of computer-based techniques for the assessment of quantitative measurements of coronary arterial dimensions. In this presentation an extensive overview of the different quantitative approaches will be given.

Key elements in these systems are the cine-digitizer for the 35 mm cinefilm approaches and the digital camera for the on-line approaches, the software for the semi- or fully-automated contour detection of a catheter segment (calibration) and of the coronary arterial segment (first-, second-derivative approaches or combination), and the software for the assessment of clinically relevant parameters. It is important to know whether the contour data are corrected for pincushion distortion, for the line-spread function of the X-ray system, and for the differential magnification between the catheter segment and the analyzed arterial segment. Furthermore, the question arises how the data from biplane analyses are being handled. Densitometric techniques have been developed for the assessment of absolute and relative cross-sectional area stenosis from a single angiographie view. In these cases data must be presented on calibration and correction procedures, since there are many nonlinear components in the densitometric image analysis chain.

A complete set of quantitative parameters should include obstruction and reference (how defined?) diameters and areas (circular, elliptical or densitometric approach), extent of obstruction, %-diameter and area stenosis, asymmetry of stenosis, area atherosclerotic plaque, the roughness of the arterial segment, and transstenotic pressure gradient at a given flow. Validation procedures must include data on the accuracy and precision of the edge detection technique based on (perspex) models with obstruction sizes ranging from 0.5 to 5 mm, as well as on in-vivo models. Furthermore, data on the results from repeated analyses of angiographic studies (reproducibility), and for the densitometric approach data on the variability from different views and under different X-ray system settings must be presented. It is proposed that the validation data are given in terms of the mean difference (accuracy) and standard deviation of the differences (precision) between corresponding measurements.

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  1. Johan H. C. Reiber
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Editors and Affiliations

  1. Institute of Cardiology, Thoraxcenter, Erasmus University, Rotterdam, The Netherlands

    Johan H. C. Reiber PhD  & Patrick W. Serruys MD FACC  & 

  2. University Hospital Dijkzigt, Rotterdam, The Netherlands

    Johan H. C. Reiber PhD  & Patrick W. Serruys MD FACC  & 

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© 1988 Kluwer Academic Publishers

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Reiber, J.H.C. (1988). Morphologic and densitometric quantitation of coronary stenoses; an overview of existing quantitation techniques. In: Reiber, J.H.C., Serruys, P.W. (eds) New Developments in Quantitative Coronary Arteriography. Developments in Cardiovascular Medicine, vol 87. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1309-7_4

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  • DOI: https://doi.org/10.1007/978-94-009-1309-7_4

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