Abstract
Riboflavin is a water-soluble vitamin which can be produced on a commercial scale by various fermentation processes using various micro-organisms. Riboflavin is used pure for human nutrition and therapy and in the crude concentrated form for animal feed supplements. Although it is produced by both synthetic and fermentation processes, it is believed that the microbial synthesis should be able to compete quite successfully with the synthetic chemical processes.
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References
Ainsworth, G. C. & Sussman, A. S. (1965). The Fungi, Academic Press, New York, pp. 37, 492.
Brit. Pat. 621,468 (April 11 1949) (to Commercial Solvents Corp.).
Demain, A. L. (1972). Riboflavin oversynthesis, In Annual Reviews of Microbiology Vol. 26, ed. C. E. Clyton, S. Raffel & M. P. Starr. George Benta Inc., USA, pp. 369–88.
Goodwin, T. W. (1959). Production and biosynthesis of riboflavin in micro-organisms. In Progress In Industrial Microbiology, ed. D. J. D. Hockenhull. Heywood & Company, London, pp. 139–177.
Goodwin, T. W. (1963a). Vitamins. In Biochemistry of Industrial Micro-organisms, ed. C. Rainbow & A. H. Rose. Academic Press, London, pp. 151–8
Goodwin, T. W (1963b). Riboflavin and related compounds. In The Biosynthesis of Vitamins and Related Compounds, ed. T. W. Goodwin. Academic Press, London, pp. 24–35.
Gutcho, S. J (1973). Chemicals by Fermentation, Noyes Data Corporation, Chemical Technology Review No. 19, New Jersey, pp. 323–25.
Heimann, W. (1980). Fundamentals of Food Chemistry, Ellis Horwood, Chichester, pp. 212–14.
Hickey, R. J. (1954). Production of riboflavin by fermentation. In Industrial Fermentations, ed. L. A. Underkofler & R. J. Hickey. Chemical Publishing Co., New York, pp. 157–90.
Kirk, R. E. & Othmer, D. F. (1968). Encyclopedia of Chemical Technology, Vol. 17, John Wiley & Sons, New York, pp. 445–58.
Lago, B. D. & Kaplan, L. (1981). Vitamin fermentations: B2 and B12. Adv. in Biotech., 3, 241–6.
Özbas, T., Kutsal, T. & Caglar, A. (1984). The production of riboflavin by Eremothecium ashbyii at various media. In Proceedings of the 3rd European Congress on Biotechnology, ed. D. Behrens, Verlag Chemie GmbH, Weinheim, pp. 389–94.
Ă–zbas, T. (1985). Eremothecium ashbyii Ashbya gossypii Mikroorganizmalari lie Riboflavin Ăśretimi. MSc thesis, Hacettepe University, Ankara, Turkey.
Özbas, T. & Kutsal, T. (1986a). Riboflavin production by Eremothecium ashbyii in a batch stirred tank fermenter. Biotechnology Letters, 8, 441–44.
Özbas, T. & Kutsal, T. (1986b). Comparative study of riboflavin production from two micro-organisms: Eremothecium ashbyii and Ashbya gossypii. Enzyme Microb. Technol, 8, 593–96.
Özbas, T. & Kutsal, T. (1987). Effects of inositol, D(+)-biotin and thiamine on riboflavin production by Ashbya gossypii. In Proceedings of the 4th European Congress on Biotechnology, ed. O. M. Neijssel, R. R. van der Meer & K. Ch. A. M. Luyben. Elsevier Science Publishers B.V., Amsterdam, pp. 273–76.
Pearson, W. N. (1967). Riboflavin. In The Vitamins, ed. P. György & W. N. Pearson. Academic Press, New York, pp. 99–101.
Perlman, D. (1979). Microbial process for riboflavin production. In Microbial Technology, ed. H. J. Peppier & D. Perlman. Academic Press, New York, pp. 521–7.
Perlman, D., Brown, W. E. &3xamp; Sylvan, B. L. (1952). Fermentation. Ind. Eng. Chem., 44, 1996–2001.
Pfeifer, V. F., Tanner, F. W., Vojnovich, C. Jr & Traufler, D. H. (1950). Riboflavin by fermentation with Ashbya gossypii. Ind. Eng. Chem., 42, 1776–81.
Robinson, F. A. (1966). The Vitamin Co-factors of Enzyme Systems, Pergamon Press, Braunschweig, pp. 160–63.
Smith, J. E. & Berry, D. R. (1975). The Filamentous Fungi, Vol. 1, Edward Arnold. London, pp. 67–8, 115–116.
US Pat. 2 367 644 (January 16 1945), G. E. Hines, Jr (to Commercial Solvents Corp.).
US Pat. 2 367 646 (January 16 1945), M. G. W. Millian (to Commercial Solvents Corp.).
US Pat. 2 421 142 (27 May 1947) J. K. Dale (to Commercial Solvents Corp.).
Wagner-Jauregg, T. (1972). Chemistry. In The Vitamins, ed. W. H. Sebrell Jr & R. S. Harris. Academic Press, New York, pp. 3–5.
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Kutsal, T., Ă–zbas, M.T. (1989). Microbial Production of Vitamin B2 (Riboflavin). In: Vandamme, E.J. (eds) Biotechnology of Vitamins, Pigments and Growth Factors. Elsevier Applied Biotechnology Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1111-6_10
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DOI: https://doi.org/10.1007/978-94-009-1111-6_10
Publisher Name: Springer, Dordrecht
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