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Mark/Par-1 Marking the Polarity of Migrating Neurons

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Cellular and Molecular Control of Neuronal Migration

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 800))

Abstract

Proper brain development requires the orchestrated migration of neurons from their place of birth to their final positioning, where they will form appropriate connections with their target cells. These events require coordinated activity of multiple elements of the cytoskeleton, in which the MARK/Par-1 polarity kinase plays an important role. Here, the various roles and modes of regulation of MARK/Par-1 are reviewed. MARK/Par-1 participates in axon formation in primary hippocampal neurons. Balanced levels of MARK/Par-1 are required for proper radial migration, as well as for migration in the rostral migratory stream. Normal neuronal migration requires at least two of MARK/Par-1 substrates, DCX and tau. Overall, the positioning of MARK/Par-1 at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions.

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Acknowledgements

 O.R. is an Incumbent of the Berstein-Mason professorial chair of Neurochemistry. Our research has been supported in part by the Israel Science Foundation (grant no. 47/10), Minerva foundation with funding from the Federal German Ministry for Education and Research, a grant from the Chief Scientist Office at the Israeli Ministry of Health, under the frame of ERA-Net NEURON (DISCover, IMOS 3-00000-6785), Fritz-Thyseen Foundation (grant Az. 10.11.2.161), the Benoziyo Center for Neurological diseases, the Helen and Martin Kimmel Stem Cell Research Institute, and the David and Fela Shapell Family Center for Genetic Disorders Research.

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  1. Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel

    Orly Reiner & Tamar Sapir

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  1. Orly Reiner
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  2. Tamar Sapir
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Correspondence to Orly Reiner or Tamar Sapir .

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  1. GIGA-Neurosciences, University of Liège, Liège, Belgium

    Laurent Nguyen

  2. Institute of Science and Technology Austria, Klosterneuburg, Niederösterreich, Austria

    Simon Hippenmeyer

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Reiner, O., Sapir, T. (2014). Mark/Par-1 Marking the Polarity of Migrating Neurons. In: Nguyen, L., Hippenmeyer, S. (eds) Cellular and Molecular Control of Neuronal Migration. Advances in Experimental Medicine and Biology, vol 800. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7687-6_6

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