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Molecular Pathways Controlling the Sequential Steps of Cortical Projection Neuron Migration

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Cellular and Molecular Control of Neuronal Migration

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 800))

Abstract

Coordinated migration of newly-born neurons to their target territories is essential for correct neuronal circuit assembly in the developing brain. Although a cohort of signaling pathways has been implicated in the regulation of cortical projection neuron migration, the precise molecular mechanisms and how a balanced interplay of cell-autonomous and non-autonomous functions of candidate signaling molecules controls the discrete steps in the migration process, are just being revealed. In this chapter, I will focally review recent advances that improved our understanding of the cell-autonomous and possible cell-nonautonomous functions of the evolutionarily conserved LIS1/NDEL1-complex in regulating the sequential steps of cortical projection neuron migration. I will then elaborate on the emerging concept that the Reelin signaling pathway, acts exactly at precise stages in the course of cortical projection neuron migration. Lastly, I will discuss how finely tuned transcriptional programs and downstream effectors govern particular aspects in driving radial migration at discrete stages and how they regulate the precise positioning of cortical projection neurons in the developing cerebral cortex.

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Acknowledgements

 I apologize to the all the authors whose relevant work could not be included in this chapter due to space constraints and thank Carl-Philipp Heisenberg, Michael Sixt and Mariapia Postiglione for helpful comments on the manuscript. This work was supported by IST Austria (Institute of Science and Technology Austria) institutional funds.

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    Simon Hippenmeyer

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    Simon Hippenmeyer

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Hippenmeyer, S. (2014). Molecular Pathways Controlling the Sequential Steps of Cortical Projection Neuron Migration. In: Nguyen, L., Hippenmeyer, S. (eds) Cellular and Molecular Control of Neuronal Migration. Advances in Experimental Medicine and Biology, vol 800. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7687-6_1

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