Skip to main content
SpringerLink
Log in

Mesenchymal Stem Cell Survival in Infarcted Myocardium: Adhesion and Anti-death Signals

  • Chapter
  • First Online:
Stem Cells and Cancer Stem Cells, Volume 10

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 10))

Abstract

Mesenchymal stem cells (MSCs) possess the unique potential for use in cell-based therapy of heart diseases, especially in ischemic heart disease. The therapeutic ability of MSCs in myocardial regeneration can give rise to differentiate into cardiac tissue and to release the paracrine factors. However, advancement in MSC therapy is hindered by the poor viability of the transplanted cells due to harmful microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, many kinds of approaches have been developed in an effort to improve the survival of engrafted MSCs through ex vivo manipulation of MSCs, including genetic modification, pretreatment, preconditioning of MSCs. This chapter will discuss various approaches in MSCs for cardiac repair and summarize the current literature in the field.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Andreadou I, Iliodromitis EK, Farmakis D, Kremastinos DT (2009) To prevent, protect and save the ischemic heart: antioxidants revisited. Expert Opin Ther Targets 13:945–956

    Article  PubMed  CAS  Google Scholar 

  • Anversa P, Kajstura J (1998) Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 83:1–14

    Article  PubMed  CAS  Google Scholar 

  • Chacko SM, Ahmed S, Selvendiran K, Kuppusamy ML, Khan M, Kuppusamy P (2010) Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol 299:C1562–C1570

    Article  PubMed  CAS  Google Scholar 

  • Chan EC, Jiang F, Peshavariya HM, Dusting GJ (2009) Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering. Pharmacol Ther 122:97–108

    Article  PubMed  CAS  Google Scholar 

  • Chang W, Song BW, Lim S, Song H, Shim CY, Cha MJ, Ahn DH, Jung YG, Lee DH, Chung JH, Choi KD, Lee SK, Chung N, Lee SK, Jang Y, Hwang KC (2009) Mesenchymal stem cells pretreated with delivered Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury. Stem Cells 27:2283–2292

    Article  PubMed  CAS  Google Scholar 

  • Chavakis E, Koyanagi M, Dimmeler S (2010) Enhancing the outcome of cell therapy for cardiac repair: progress from bench to bedside and back. Circulation 121:325–335

    Article  PubMed  Google Scholar 

  • Copland IB, Lord-Dufour S, Cuerquis J, Coutu DL, Annabi B, Wang E, Galipeau J (2009) Improved autograft survival of mesenchymal stromal cells by plasminogen activator inhibitor 1 inhibition. Stem Cells 27:467–477

    Article  PubMed  CAS  Google Scholar 

  • Eun LY, Song BW, Cha MJ, Song H, Kim IK, Choi E, Chang W, Lim S, Choi EJ, Ham O, Lee SY, Byun KH, Jang Y, Hwang KC (2010) Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium. Biochem Biophys Res Commun 402:272–279

    Article  PubMed  CAS  Google Scholar 

  • Fraser JK, Schreiber RE, Zuk PA, Hedrick MH (2004) Adult stem cell therapy for the heart. Int J Biochem Cell Biol 36:658–666

    Article  PubMed  CAS  Google Scholar 

  • Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP (1968) Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6:230–247

    Article  PubMed  CAS  Google Scholar 

  • Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ (2006) Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20:661–669

    Article  PubMed  CAS  Google Scholar 

  • Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103:1204–1219

    Article  PubMed  CAS  Google Scholar 

  • Hahn JY, Cho HJ, Kang HJ, Kim TS, Kim MH, Chung JH, Bae JW, Oh BH, Park YB, Kim HS (2008) Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 51:933–943

    Article  PubMed  CAS  Google Scholar 

  • Hu X, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L (2008) Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg 135:799–808

    Article  PubMed  CAS  Google Scholar 

  • Husnain HK, Ashraf M (2005) Bone marrow stem cell transplantation for cardiac repair. Am J Physiol Heart Circ Physiol 288:H2557–H2567

    Article  Google Scholar 

  • Li W, Ma N, Ong LL, Nesselmann C, Klopsch C, Ladilov Y, Furlani D, Piechaczek C, Moebius JM, Lützow K, Lendlein A, Stamm C, Li RK, Steinhoff G (2007) Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 25:2118–2127

    Article  PubMed  CAS  Google Scholar 

  • Li JH, Zhang N, Wang JA (2008) Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy. J Endocrinol Invest 31:103–110

    PubMed  CAS  Google Scholar 

  • Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ (2003) Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9:1195–1201

    Article  PubMed  CAS  Google Scholar 

  • Michel JB (2003) Anoikis in the cardiovascular system: known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol 23:2146–2154

    Article  PubMed  CAS  Google Scholar 

  • Nelson TJ, Martinez-Fernandez A, Terzic A (2010) Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat Rev Cardiol 7:700–710

    PubMed  Google Scholar 

  • Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701–705

    Article  PubMed  CAS  Google Scholar 

  • Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M (2008) Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res 77:134–142

    Article  PubMed  CAS  Google Scholar 

  • Paul D, Samuel SM, Maulik N (2009) Mesenchymal stem cell: present challenges and prospective cellular cardiomyoplasty approaches for myocardial regeneration. Antioxid Redox Signal 11:1841–1855

    Article  PubMed  CAS  Google Scholar 

  • Penn MS, Mangi AA (2008) Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res 102:1471–1482

    Article  PubMed  CAS  Google Scholar 

  • Robey TE, Saiget MK, Reinecke H, Murry CE (2008) Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol 45:567–581

    Article  PubMed  CAS  Google Scholar 

  • Ryan JM, Barry FP, Murphy JM, Mahon BP (2005) Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) 26:8

    Article  Google Scholar 

  • Satija NK, Singh VK, Verma YK, Gupta P, Sharma S, Afrin F, Sharma M, Sharma P, Tripathi RP, Gurudutta GU (2009) Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Cell Mol Med 13:4385–4402

    Article  PubMed  CAS  Google Scholar 

  • Segers VF, Lee RT (2008) Stem-cell therapy for cardiac disease. Nature 451:937–942

    Article  PubMed  CAS  Google Scholar 

  • Shujia J, Haider HK, Idris NM, Lu G, Ashraf M (2008) Stable therapeutic effects of mesenchymal stem cell-based multiple gene delivery for cardiac repair. Cardiovasc Res 77:525–533

    Article  PubMed  CAS  Google Scholar 

  • Song H, Chang W, Lim S, Seo HS, Shim CY, Park S, Yoo KJ, Kim BS, Min BH, Lee H, Jang Y, Chung N, Hwang KC (2007) Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells. Stem Cells 25:1431–1438

    Article  PubMed  CAS  Google Scholar 

  • Song SW, Chang W, Song BW, Song H, Lim S, Kim HJ, Cha MJ, Choi E, Im SH, Chang BC, Chung N, Jang Y, Hwang KC (2009) Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium. Stem Cells 27:1358–1365

    Article  PubMed  CAS  Google Scholar 

  • Song H, Cha MJ, Song BW, Kim IK, Chang W, Lim S, Choi EJ, Ham O, Lee SY, Chung N, Jang Y, Hwang KC (2010a) Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex. Stem Cells 28:555–563

    PubMed  CAS  Google Scholar 

  • Song H, Song BW, Cha MJ, Choi IG, Hwang KC (2010b) Modification of mesenchymal stem cells for cardiac regeneration. Expert Opin Biol Ther 10:309–319

    Article  PubMed  Google Scholar 

  • Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD (2002) Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105:93–98

    Article  PubMed  Google Scholar 

  • Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, Fan GC (2009) Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells 27:3021–3031

    PubMed  CAS  Google Scholar 

  • Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y (2008) Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol 44:281–292

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grants of a Korea Science and Engineering Foundation grant funded by the Korean government (MEST) (2011-001943, 2011-0019254) and the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120478).

Author information

Authors and Affiliations

  1. Institute of Catholic Integrative Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Incheon, Republic of Korea

    Woochul Chang

  2. Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

    Byeong-Wook Song

  3. Severance Biomedical Institute, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

    Ki-Chul Hwang

Authors
  1. Woochul Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Byeong-Wook Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ki-Chul Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ki-Chul Hwang .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Chang, W., Song, BW., Hwang, KC. (2013). Mesenchymal Stem Cell Survival in Infarcted Myocardium: Adhesion and Anti-death Signals. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_4

Download citation

Publish with us

Policies and ethics

Search

Navigation