Skip to main content
SpringerLink
Log in

Acupuncture and Moxibustion in Animal Models of Cancer

  • Chapter
  • First Online:
Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 3))

Abstract

Recent advances in oncological acupuncture research provide evidence to support the use of acupuncture and moxibustion for symptom management in cancer patients. Studies in tumor-bearing animals demonstrate that acupuncture significantly enhances immune function by decreasing the percentage of CD4+ CD25+ regulatory T cells and increasing natural killer (NK) cell activity. The modality’s effect on NK cells has been shown to be mediated by β-endorphins. Acupuncture also has been shown to inhibit spinal interleukin-1β, dynorphin, and substance P to suppress cancer-induced pain, as well as to activate spinal opioids that alleviate chemotherapy-induced pain. Data from animal studies support the use of acupuncture for chemotherapy-induced emesis and suggest that it can improve cancer-induced depression. Moxibustion has also been shown to improve immune cell function by increasing NK cell activity, and it may alleviate cancer-induced pain. Although animal studies do not mimic human studies exactly, they reveal mechanisms by which these complementary therapies improve cancer-related symptoms. Most cancer patients experience multiple symptoms related either to cancer itself or to treatment effects. Since acupuncture and moxibustion alleviate some of these symptoms, use of these modalities has the potential to improve the patients’ quality of life.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahn, A. C., Colbert, A. P., Anderson, B. J., Martinsen, O. G., Hammerschlag, R., Cina, S., et al. (2008). Electrical properties of acupuncture points and meridians: A systematic review. Bioelectromagnetics, 29, 245–256.

    Article  PubMed  Google Scholar 

  • Andreescu, C., Glick, R. M. Emeremni, C. A., Houck, P. R., & Mulsant, B. H. (2011). Acupuncture for the treatment of major depressive disorder: A randomized controlled trial. The Journal of Clinical Psychiatry, 72, 1129–1135.

    Article  PubMed  Google Scholar 

  • Argyriou, A. A., Zolota, V., Kyriakopoulou, O., & Kalofonos, H. P. (2010). Toxic peripheral neuropathy associated with commonly used chemotherapeutic agents. The Official Journal of Balkan Union of Oncology, 15, 435–446.

    CAS  Google Scholar 

  • Armstrong, T., Almadrones, L., & Gilbert, M. R. (2005). Chemotherapy-induced peripheral neuropathy. Oncology Nursing Forum, 32, 305–311.

    Article  PubMed  Google Scholar 

  • Balk, J., Day, R., Rosenzweig, M., & Beriwal, S. (2009). Pilot, randomized, modified, double-blind, placebo-controlled trial of acupuncture for cancer-related fatigue. Journal of the Society for Integrative Oncology, 7, 4–11.

    PubMed  Google Scholar 

  • Bao, T., Zhang, R. X., Badros, A., & Lao, L. (2011). Acupuncture Treatment for Bortezomib-Induced Peripheral Neuropathy: A Case Report. Pain Research and Treatment: doi:10.1155/2011/920807.

    Google Scholar 

  • Basch, E., Prestrud, A. A. Hesketh, P. J. Kris, M. G., Feyer, P. C., Somerfield, M. R., et al. (2011). Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update. Journal of Clinical Oncology, 29, 4189–4198.

    Article  PubMed  Google Scholar 

  • Berman, B. M., Lao, L., Langenberg, P., Lee, W. L., Gilpin, A. M., & Hochberg, M. C. (2004). Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: A randomized, controlled trial. Annals of Internal Medicine, 141, 901–910.

    PubMed  Google Scholar 

  • Bhagra, A., & Rao, R. D. (2007). Chemotherapy-induced neuropathy. Current Oncology Reports, 9, 290–299.

    Article  PubMed  CAS  Google Scholar 

  • Brunelli, B., & Gorson, K. C. (2004). The use of complementary and alternative medicines by patients with peripheral neuropathy. Journal of the Neurological Sciences, 218, 59–66.

    Article  PubMed  Google Scholar 

  • Cheng, H. L., Han, W., Hu, P. J., & Yang, J. (2008). Selection of objects separated moxibustion dialectic treatment of knee osteoarthritis in primary clinical research Clinical Journal of Traditional Chinese Medicine, 20, 114–116.

    Google Scholar 

  • Cho, J. H., Chung, W. K., Kang, W., Choi, S. M., Cho, C. K., & Son, C. G. (2008). Manual acupuncture improved quality of life in cancer patients with radiation-induced xerostomia. Journal of Alternative and Complementary Medicine, 14, 523–526.

    Article  Google Scholar 

  • Choi, G. S., Oha, S. D., Han, J. B., Bae, H. S., Cho, Y. W., Yun, Y. S., et al. (2002). Modulation of natural killer cell activity affected by electroacupuncture through lateral hypothalamic area in rats. Neuroscience Letters, 329, 1–4.

    Article  PubMed  CAS  Google Scholar 

  • Choi, T. Y., Lee, M. S., Kim, T. H., Zaslawski, C., & Ernst, E. (2012). Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Supportive Care in Cancer, 20, 1147–1158.

    Google Scholar 

  • Chong, M. S., & Bajwa, Z. H. (2003). Diagnosis and Treatment of Neuropathic Pain. Journal of Pain and Symptom Management, 25, S4-S11.

    Article  PubMed  Google Scholar 

  • Chu, L. C., Tsaur, M. L., Lin, C. S., Hung, Y. C., Wang, T. Y., Chen, C. C., et al. (2011). Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia, 106, 699–705.

    Article  PubMed  CAS  Google Scholar 

  • Cleary, J. F. (2000). Cancer pain management. Cancer Control, 7, 120–131.

    PubMed  CAS  Google Scholar 

  • Dang, W., & Yang, J. (1998). Clinical study on acupuncture treatment of stomach carcinoma pain. Journal of Traditional Chinese Medicine, 18, 31–38.

    PubMed  CAS  Google Scholar 

  • Dibble, S. L., Luce, J., Cooper, B. A., Israel, J., Cohen, M., Nussey, B., et al. (2007). Acupressure for chemotherapy-induced nausea and vomiting: A randomized clinical trial. Oncology Nursing Forum, 34, 813–820.

    Article  PubMed  Google Scholar 

  • Diener, H-C., Kronfeld, K., Boewing, G., Lungenhausen, M., Maier, C., Molsberger, A., et al. (2006). Efficacy of acupuncture for the prophylaxis of migraine: A multicentre randomised controlled clinical trial. Lancet Neurology, 5, 310–316.

    Article  PubMed  Google Scholar 

  • Donald, G. K., Tobin, I., & Stringer, J. (2011). Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupuncture in Medicine, 29, 230–233.

    Article  PubMed  Google Scholar 

  • Dos Santos, J. G., Jr., Kawano, F., Nishida, M. M., Yamamura, Y., Mello, L. E., & Tabosa, A. (2008). Antidepressive-like effects of electroacupuncture in rats. Physiology & Behavior, 93, 155–159.

    Article  CAS  Google Scholar 

  • Dworkin, R. H., O’Connor, A. B., Audette, J., Baron, R., Gourlay, G. K., Haanpaa, M. L., et al. (2010). Recommendations for the pharmacological management of neuropathic pain: An overview and literature update. Mayo Clinic Proceedings, 85, S3–14.

    Article  PubMed  CAS  Google Scholar 

  • Feng, Y., Wang, X. Y., Li, S. D., Zhang, Y., Wang, H. M., Li, M., et al. (2011). Clinical research of acupuncture on malignant tumor patients for improving depression and sleep quality. Journal of Traditional Chinese Medicine, 31, 199–202.

    Article  PubMed  Google Scholar 

  • Ferguson, J. (2001). SSRI Antidepressant Medications: Adverse Effects and Tolerability. Prim Care Companion. The Journal of Clinical Psychiatry, 3, 22–27.

    Google Scholar 

  • Flatters, S. J. L., & Bennett, G. J. (2006). Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction. Pain, 122, 245–257.

    Article  PubMed  CAS  Google Scholar 

  • Frisk, J., Källström, A. C., Wall, N., Fredrikson, M., & Hammar, M. (2012). Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes. Support Care Cancer, 20, 715–724.

    Google Scholar 

  • Gardani, G., Cerrone, R., Biella, C., Galbiati, G., Proserpio, E., Casiraghi, M., et al. (2007). A progress study of 100 cancer patients treated by acupressure for chemotherapy-induced vomiting after failure with the pharmacological approach. Minerva Medica, 98, 665–668.

    PubMed  CAS  Google Scholar 

  • Goldman, N., Chen, M., Fujita, T., Xu, Q., Peng, W., Liu, W., et al. (2010). Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nature Neuroscience, 13, 883–888.

    Article  PubMed  CAS  Google Scholar 

  • Gong, Q-J., Li, Y-Y., Xin, W-J., Wei, X-H., Cui, Y., Wang, J., et al. (2010). Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Research, 1361, 23–30.

    Article  PubMed  CAS  Google Scholar 

  • Han, J. S. (2003). Acupuncture: Neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences, 26, 7–22.

    Article  Google Scholar 

  • Hausheer, F. H., Schilsky, R. L., Bain, S., Berghorn, E. J., & Lieberman, F. (2006). Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Seminars in Oncology, 33, 15–49.

    Article  PubMed  CAS  Google Scholar 

  • He, L. F. (1987). Involvement of endogenous opioid peptides in acupuncture analgesia. Pain, 31, 99–121.

    Article  PubMed  CAS  Google Scholar 

  • Jiang, L. H., & Wang, L. L. (2010). Gene chips-aided analysis on the profiles of hippocampal whole-genome expression in depression rats following electroacupuncture treatment. Acupuncture Research, 35, 83–89.

    PubMed  Google Scholar 

  • Jonsdottir, I. H., Johansson, C., Asea, A., Hellstrand, K., Thorén, P., & Hoffmann, P. (1996). Chronic intracerebroventricular administration of beta-endorphin augments natural killer cell cytotoxicity in rats. Regulatory Peptides, 62, 113–118.

    Article  PubMed  CAS  Google Scholar 

  • Judith, A. P. (2009). Clinical Challenges: Chemotherapy-Induced Peripheral Neuropathy. Seminars in Oncology Nursing, 25, S8-S19.

    Article  Google Scholar 

  • Kaley, T. J., & DeAngelis, L. M. (2009). Therapy of chemotherapy-induced peripheral neuropathy. British Journal of Haematology, 145, 3–14.

    Article  PubMed  CAS  Google Scholar 

  • Kim, C. K., Choi, G. S., Oh, S. D., Han, J. B., Kim, S. K., Ahn, H. J., et al. (2005). Electroacupuncture up-regulates natural killer cell activity: Identification of genes altering their expressions in electroacupuncture induced up-regulation of natural killer cell activity. Journal of Neuroimmunology, 168, 144–153.

    Article  PubMed  CAS  Google Scholar 

  • Kim, J. H., Kim, H. K., Park, Y. I., Sohn, I. C., Choi, D. O., Kim, M. S., et al. (2006). Moxibustion at ST36 alleviates pain in complete Freund’s adjuvant-induced arthritic rats. The American Journal of Chinese Medicine, 34, 57–67.

    Article  PubMed  Google Scholar 

  • Kirshbaum, M. (2010). Cancer-related fatigue: A review of nursing interventions. British Journal of Community Nursing, 15, 214–216.

    PubMed  Google Scholar 

  • Lai, M., Wang, S. M., Wang, Y., Tang, C. L., Kong, L. W., & Xu, X. Y. (2008a). Effects of electroacupuncture of “Zusanli” (ST 36), “Hegu” (LI 4) and/or “Sanyinjiao” (SP 9) on immunofunction in gastric carcinectomy rats. Acupuncture Research, 33, 245–249.

    Google Scholar 

  • Lai, M., Wang, S. M., Zhang, W. L., Wang, Y., Huang, S. Q., Dong, W., et al. (2008b). Effects of electroacupuncture on tumor growth and immune function in the Walker-256 model rat. Zhongguo Zhen jiu, 28, 607–609.

    CAS  Google Scholar 

  • Lao, L., Wong, R. H., Berman, B., & Wynn, R. L. (1995). Electroacupuncture reduces morphine-induced emesis in ferrets: A pilot study. Journal of Alternative and Complementary Medicine, 1, 257–261.

    Article  CAS  Google Scholar 

  • Lao, L., Zhang, G., Wong, R. H., Carter, A. K., Wynn, R. L., & Berman, B. M. (2003). The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets. Pharmacology, Biochemistry, and Behavior, 74, 691–699.

    Article  PubMed  CAS  Google Scholar 

  • Lao, L., Zhang, R-X., Zhang, G., Wang, X., Berman, B. M., & Ren, K. (2004). A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Research, 1020, 18–29.

    Article  PubMed  CAS  Google Scholar 

  • Lee, B., Shim, I., Lee, H. J., Yang, Y., & Hahm, D. H. (2009a). Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. Neuroscience Letters, 453, 151–156.

    Article  CAS  Google Scholar 

  • Lee, H. J., Lee, J. H., Lee, E. O., Lee, H. J., Kim, K. H., Lee, K. S., et al. (2009b). Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model. Acupuncture & Electro-Therapeutics Research, 34, 27–40.

    Google Scholar 

  • Lee, M. S., Choi, T., Kang, J. W., Lee, B., & Ernst, E. (2010a). Moxibustion for treating pain: A systematic review. The American Journal of Chinese Medicine, 38, 829–838.

    Article  Google Scholar 

  • Lee, M. S., Choi, T. Y., Park, J. E., Lee, S. S., & Ernst, E. (2010b). Moxibustion for cancer care: A systematic review and meta-analysis. BMC Cancer, 10, 130.

    Article  CAS  Google Scholar 

  • Len, J., Xu, G., Liu, W., & Zhang, Q. (1991). The regulating effect of electroacupuncture on gastroenteric electric activity in guinea pigs of peripheral vomiting. Acupuncture Research, 16, 69–72.

    PubMed  CAS  Google Scholar 

  • Leo, R. J., & Ligot, J. S. Jr (2007). A systematic review of randomized controlled trials of acupuncture in the treatment of depression. Journal of Affective Disorders, 97, 13–22.

    Article  PubMed  Google Scholar 

  • Li, W. G. (2007). Cotton Moxibustion treatment of herpes zoster clinical observation of 30 cases. Journal of Practical Traditional Chinese Internal Medicine, 21, 97.

    CAS  Google Scholar 

  • Lim, S., Ryu, Y-H., Kim, S-T., Hong, M-S., & Park, H-J. (2003). Acupuncture increases neuropeptide Y expression in hippocampus of maternally-separated rats. Neuroscience Letters, 343, 49–52.

    Article  PubMed  CAS  Google Scholar 

  • Liu, L. J., Guo, C. J., Jiao, X. M., Liu, L. J., Guo, C. J., & Jiao, X. M. (1995). Effect of acupuncture on immunologic function and histopathology of transplanted mammary cancer in mice. Chinese Journal of Integrative Traditional Western Medicine, 15, 615–617.

    CAS  Google Scholar 

  • Liu, J., Lee, Y. T., Lee, S. E., Lee, J. Y., & Kim, D. H. (2007). Anti-emetic effect of oculo-acupuncture on dogs with xylazine induced vomiting. The American Journal of Chinese Medicine, 35, 447–453.

    Article  PubMed  Google Scholar 

  • Liu, Z. D., Pei, J., Fu, Q. H., Li, H. Y., Yu, Q. W., Zhang, J. Y., et al. (2009). Influence of electroacupuncture and moxibustion and their treated mouse serum on the proliferation of the cultured splenetic CD4+ CD25+ regulatory T cells of tumor-bearing mice. Acupuncture Research, 34, 219–224.

    PubMed  CAS  Google Scholar 

  • Liu, L. L., Zhao, B. X., Xie, Z. H., & Fan, Y. P. (2010). Changes of electrical property of the twelve source-points in encephaloma patients before and after surgery. Acupuncture Research, 35, 52–55.

    PubMed  Google Scholar 

  • Liyanage, U. K., Goedegebuure, P. S., Moore, T. T., Viehl, C. T., Moo-Young, T. A., Larson, J. W., et al. (2006). Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. Journal of Immunotherapy, 29, 416–424.

    Article  PubMed  Google Scholar 

  • Lorusso, L. M. S., Capelli, E., Ferrari, D., Ngonga, G. K., & Ricevuti, G. (2009). Immunological aspects of chronic fatigue syndrome. Autoimmunity Reviews, 8, 287–291.

    Article  PubMed  CAS  Google Scholar 

  • Lu, F., Zhu, H. M., Xie, J. J., Zhou, H. H., Chen, Y. L., & Hu, J. Y. (2008). Effects of electroacupuncture on behavior, plasma COR and expressions of PKA and PKC in hippocampus of the depression model rat. Zhongguo Zhen Jiu, 28, 214–218.

    PubMed  CAS  Google Scholar 

  • Lu, W., Matulonis, U. A., Doherty-Gilman, A., Lee, H., Dean-Clower, E., Rosulek, A., et al. (2009). Acupuncture for chemotherapy-induced neutropenia in patients with gynecologic malignancies: A pilot randomized, sham-controlled clinical trial. Journal of Alternative and Complementary Medicine, 15, 745–753.

    Article  Google Scholar 

  • Malik, B., & Stillman, M. (2008). Chemotherapy-induced peripheral neuropathy. Current Neurology and Neuroscience Reports, 8, 56–65.

    Article  PubMed  CAS  Google Scholar 

  • Mao-Ying, Q. L., Cui, K. M., Liu, Q., Dong, Z. Q., Wang, W., Wang, J., et al. (2006). Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain. European Journal of Pain, 10, 689–694.

    Article  PubMed  Google Scholar 

  • Mao-Ying, Q. L., Ren, D. H., Mi, W. L., Liu, Q., & Wang, Y. Q. (2008). Analgesic effects of electroacupuncture combined with Celebrex on rats with tibial cancer pain. Journal of Chinese Integrative Medicine, 6, 830–835.

    Article  CAS  Google Scholar 

  • Mayer, D. J. (2000). Biological mechanisms of acupuncture. Progress in Brain Research, 122, 457–477.

    Article  PubMed  CAS  Google Scholar 

  • Mehnert, A., & Koch, U. (2008). Psychological comorbidity and health-related quality of life and its association with awareness, utilization, and need for psychosocial support in a cancer register-based sample of long-term breast cancer survivors. Journal of Psychosomatic Research, 64, 383–391.

    Article  PubMed  Google Scholar 

  • Melchart, D., Streng, A., Hoppe, A., Brinkhaus, B., Witt, C., Wagenpfeil, S., et al. (2005). Acupuncture in patients with tension-type headache: Randomised controlled trial. British Medical Journal, 331, 376–382.

    Article  PubMed  Google Scholar 

  • Meng, X., Zhang, Y., Li, A., Xin, J., Lao, L., Ren, K., et al. (2011). The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. Brain Research, 1414, 58–65.

    Article  PubMed  CAS  Google Scholar 

  • Molassiotis, A., Sylt, P., & Diggins, H. (2007). The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: A randomised controlled trial. Complementary Therapies in Medicine, 15, 228–237.

    Article  PubMed  Google Scholar 

  • Napadow, V., Makris, N., Liu, J., Kettner, N. W., Kwong, K. K., & Hui, K. K. S. (2005). Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Human Brain Mapping, 24, 193–205.

    Article  PubMed  Google Scholar 

  • O’Regan, D., & Filshie, J. (2010). Acupuncture and cancer. Autonomic Neuroscience: Basic & Clinical, 157, 96–100.

    Article  Google Scholar 

  • Pachman, D. R., Barton, D. L., Watson, J. C., & Loprinzi, C. L. (2011). Chemotherapy-Induced Peripheral Neuropathy: Prevention and Treatment. Clinical Pharmacology and Therapeutics, 90, 377–387.

    Article  PubMed  CAS  Google Scholar 

  • Paley, C. A., & Johnson, M. I. (2011). Acupuncture for cancer-induced bone pain: A pilot study. Acupuncture in Medicine: Journal of the British Medical Acupuncture Society, 29, 71–73.

    Article  Google Scholar 

  • Paley, C. A., Johnson, M. I., & Bennett, M. I. (2011a). Should physiotherapists use acupuncture for treating patients with cancer-induced bone pain? A discussion paper. Physiotherapy, 97, 256–263.

    Article  Google Scholar 

  • Paley, C. A., Johnson, M. I., Tashani, O. A., & Bagnall, A. M. (2011b). Acupuncture for cancer pain in adults. Cochrane Database of Systematic Reviews, 1, CD007753.

    Google Scholar 

  • Pei, J., We, IH., Liu, Z. D., Yu, Y. M., Ni, C. R., & Wu, H. G. (2010). Effects of moxibustion on the expression of IL-1beta, IL-2, IL-6 mRNA and protein in the cerebral cortex in tumor-bearing mice. Acupuncture Research, 35, 243–249.

    PubMed  CAS  Google Scholar 

  • Peltier, A. C., & Russell, J. W. (2002). Recent advances in drug-induced neuropathies. Current Opinion in Neurology, 15, 633–638.

    Article  PubMed  Google Scholar 

  • Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001). A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain, 94, 293–304.

    Article  PubMed  CAS  Google Scholar 

  • Qin, F. H., & Qin, Y. H. (2001). Therapy of pressing and moxibustion in treating 36 cases of pain due to primary liver cancer. Zhongguo Zhen Jiu, 21, 540.

    Google Scholar 

  • Qiu, X., Chen, K., Tong, L., Shu, X., Lü, X., Wen, H., et al. (2004). Effects of moxibustion at shenque (CV 8) on serum IL-12 level and NK cell activities in mice with transplanted tumor. Journal of Traditional Chinese Medicine, 24, 56–58.

    PubMed  Google Scholar 

  • Quasthoff, S., & Hartung, H. P. (2002). Chemotherapy-induced peripheral neuropathy. Journal of Neurology, 249, 9–17.

    Article  PubMed  CAS  Google Scholar 

  • Reale, C., Turkiewicz, A. M., & Reale, C. A. (2001). Antalgic treatment of pain associated with bone metastases. Critical Reviews in Oncology/Hematology, 37, 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Salvo, N., Zeng, L., Zhang, L., Leung, M., Khan, L., Presutti, R., et al. (2011). Frequency of reporting and predictive factors for anxiety and depression in patients with advanced cancer. Clinical Oncology (Royal College of Radiologists), 24, 139–148.

    Google Scholar 

  • Sarkar, D. K., Boyadjieva, N. I., Chen, C. P., Ortigüela, M., Reuhl, K., Clement, E. M., et al. (2008). Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth. Proceedings of the National Academy of Sciences of the United States of America, 105, 9105–9110.

    Article  PubMed  CAS  Google Scholar 

  • Sarkar, D. K., Zhang, C., Murugan, S., Dokur, M., Boyadjieva, N. I., Ortigüela, M., et al. (2011). Transplantation of β-Endorphin Neurons into the Hypothalamus Promotes Immune Function and Restricts the Growth and Metastasis of Mammary Carcinoma. Cancer Research, 71, 6282–6291.

    Article  PubMed  CAS  Google Scholar 

  • She, Y. F., Qi, C. H., & Zhu, J. (2010). History and progress of study on electrical properties of acupoints at home and abroad. Zhongguo Zhen Jiu 2010, 30, 1047–1050.

    Google Scholar 

  • Strang, P. (1998). Cancer pain–a provoker of emotional, social and existential distress. Acta Oncologica, 37, 641–644.

    Article  PubMed  CAS  Google Scholar 

  • Sun, K., Yang, Y. H., Zhou, Z. L., Yang, J., & Shen, D. K. (2008). Clinical observations on the treatment of primary genual osteoarthritis of liver-kidney depletion type by aconite cake-separated moxibustion. Shanghai J Acupunct Moxibustion, 27, 9–10.

    CAS  Google Scholar 

  • Taspinar, A., & Sirin, A. (2010). Effect of acupressure on chemotherapy-induced nausea and vomiting in gynecologic cancer patients in Turkey. European Journal of Oncology Nursing, 14, 49–54.

    Article  PubMed  Google Scholar 

  • Taylor, D., Meader, N., Bird, V., Pilling, S., Creed, F., Goldberg, D., et al. (2011). Pharmacological interventions for people with depression and chronic physical health problems: Systematic review and meta-analyses of safety and efficacy. The British Journal of Psychiatry, 198, 179–188.

    Article  PubMed  Google Scholar 

  • Uryu, N., Okada, K., & Kawakita, K. (2007). Analgesic effects of indirect moxibustion on an experimental rat model of osteoarthritis in the knee. Acupuncture in Medicine, 25, 175–183.

    Article  PubMed  Google Scholar 

  • Wakao, K., Matsuzaki, I., Terao, K., Inoue-Murayama, M., Shimojo, N., & Murayama, Y. (2000). Involvement of granzyme B expression in the enhancement of natural killer activity by beta-endorphin. Brain, Behavior, and Immunity, 14, 27–40.

    Article  PubMed  CAS  Google Scholar 

  • Wang, C., Zhou, D. F., Shuai, X. W., Liu, J. X., & Xie, P. Y. (2007). Effects and mechanisms of electroacupuncture at PC6 on frequency of transient lower esophageal sphincter relaxation in cats. World Journal of Gastroenterology, 13, 4873–4880.

    PubMed  CAS  Google Scholar 

  • Wang, J. Y., Xu, L., Zhang, R. X., & Lao, L. (2011). Traditional Chinese medicine for cancer pain. Zhong Xi Yi Jie He Xue Bao, 9, 129–134.

    Article  PubMed  Google Scholar 

  • Wang, W. J., Lu, J., Niu, C. S., Huang, Y. R., Ma, Q., A Y. G., et al. (2010). Effects of electroacupuncture of unilateral and bilateral “zusanli” (ST 36) on serum TNF-alpha, IL-1 and IL-4 levels in rats with chronic inflammatory pain. Acupuncture Research, 35, 429–432.

    PubMed  CAS  Google Scholar 

  • Wang, Z. H., Zhu, J. Y., Li, T., & Leng, X. S. (2008). Proliferation of CD4+ CD25+ regulatory T cells of rat by different cytokines in vitro. Zhonghua Yi Xue Za Zhi, 88, 844–847.

    PubMed  CAS  Google Scholar 

  • Windebank, A. J., & Grisold, W. (2008). Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System, 13, 27–46.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, S., Barton, D., Kottschade, L., Grothey, A., & Loprinzi, C. (2008). Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies. European Journal of Cancer, 44, 1507–1515.

    Article  PubMed  CAS  Google Scholar 

  • Wong, R., & Sagar, S. (2006). Acupuncture treatment for chemotherapy-induced peripheral neuropathy–a case series. Acupuncture in Medicine, 24, 87–91.

    Article  PubMed  Google Scholar 

  • Wu, B., Zhou, R. X., & Zhou, M. S. (1996). Effect of acupuncture on immunomodulation in patients with malignant tumors. Zhongguo Zhong Xi Yi Jie He Za Zhi, 16, 139–141.

    PubMed  CAS  Google Scholar 

  • Wu, P., Cao, Y., & Wu, J. (2001). Effects of moxa-cone moxibustion at Guanyuan on erythrocytic immunity and its regulative function in tumor-bearing mice. Journal of Traditional Chinese Medicine, 21, 68–71.

    PubMed  CAS  Google Scholar 

  • Yates, J., Rovis, F., Mitchell, P., Afzali, B., Tsang, J. Y., Garin, M., et al. (2007). The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. International Immunology, 19, 785–799.

    Article  PubMed  CAS  Google Scholar 

  • Ye, F., Chen, S., & Liu, W. (2002). Effects of electro-acupuncture on immune function after chemotherapy in 28 cases. Journal of Traditional Chinese Medicine, 22, 21–23.

    PubMed  Google Scholar 

  • Ye, F., Liu, D., Wang, S., & Xu, L. (2007). Effects of electro-acupuncture on T cell subpopulations, NK activity, humoral immunity and leukocyte count in patients undergoing chemotherapy. Journal of Traditional Chinese Medicine, 27, 19–21.

    PubMed  Google Scholar 

  • Yin, C. S., Jeong, H. S., Park, H. J., Baik, Y., Yoon, M. H., Choi, C. B., et al. (2008). A proposed transpositional acupoint system in a mouse and rat model. Research in Veterinary Science, 84, 159–165.

    Article  PubMed  Google Scholar 

  • Yu, Y., Kasahara, T., Sato, T., Asano, K., Yu, G-D., Fang, J-Q., et al. (1998). Role of endogenous interferon-γ on the enhancement of splenic NK cell activity by electroacupuncture stimulation in mice. Journal of Neuroimmunology, 90, 176–186.

    Article  PubMed  CAS  Google Scholar 

  • Zan, H. M., & Zhang, D. C. (1999). Application of acupuncture in relieving pain of terminal cancer. Hua Bei Mei Tan Yi Xue Yuan Xue Bao, 1, 586–587.

    Google Scholar 

  • Zhai, D., Chen, H., Wang, R., Hua, X., Ding, B., & Jiang, Y. (1994). Regulation on beta-END in tumor-bearing mice by moxibustion on Guanyuan point. Acupuncture Research, 19, 63–65.

    PubMed  CAS  Google Scholar 

  • Zhang, G. G., Yu, C., Lee, W., Lao, L., Ren, K., & Berman, B. M. (2005a). Involvement of peripheral opioid mechanisms in electroacupuncture analgesia. Explore, 1, 365–371.

    Article  Google Scholar 

  • Zhang, Q. R., & Fu, W. B. (2010). Osteoarthritis of knee joint treated with acupuncture and moxibustion. Zhongguo Zhen Jiu, 30, 375–378.

    PubMed  CAS  Google Scholar 

  • Zhang, R. X., & Lao, L. (2010). Modern Cancer Research on Chinese Medicine: Acupuncture. In W. C. Cho (Ed.), Supportive cancer care with Chinese medicine (pp. 253–270). Heidelberg: Springer.

    Chapter  Google Scholar 

  • Zhang, R. X., Li, A., Liu, B., Wang, L., Ren, K., Qiao, J. T., et al. (2008a). Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model. Anesthesia and Analgesia, 105, 1482–1488.

    Article  CAS  Google Scholar 

  • Zhang, R. X., Li, A., Liu, B., Wang, L., Xin, J., Ren, K., et al. (2008b). Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model. European Journal of Pain, 12, 870–878.

    Article  CAS  Google Scholar 

  • Zhang, R. X., Liu, B., Wang, L., Ren, K., Qiao, J. T., Berman, B. M., et al. (2005b). Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain, 118, 125–136.

    Article  CAS  Google Scholar 

  • Zhang, S. Y., & Du, Y. Q. (2011). Effects of warming needle moxibustion on improvement of gastrointestinal and immune function in patients with postoperation of colorectal cancer. Zhongguo Zhen Jiu, 31, 513–517.

    PubMed  CAS  Google Scholar 

  • Zhang, W., Zhao, G. G., Su, L. Q., Zheng, Li. X., & Zhi-Hong, Y. (2011a). Effect, of acupuncture of different acupoints on immune function in rats with exhausted swimming. Acupuncture Research, 36, 181–186.

    CAS  Google Scholar 

  • Zhang, Y., Li, A., Lao, L., Xin, J., Ren, K., Berman, B. M., et al. (2011b). Rostral ventromedial medulla µ but not κ, opioid receptors are involved in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model. Brain Research, 1395, 38–45.

    Article  CAS  Google Scholar 

  • Zhang, Z., Wang, C., Gu, G., Li, H., Zhao, H., Wang, K., et al. (2012). The effects of electroacupuncture at the ST36 (Zusanli) acupoint on cancer pain and transient receptor potential vanilloid subfamily 1 expression in Walker 256 tumor-bearing rats. Anesthesia & Analgesia, 114, 879–885.

    Google Scholar 

  • Zhao, C. L., Peng, L. J., Zhang, Z. L., Zhang, T., & Li, H. M. (2010). Effect of acupuncture on the activity of the peripheral blood T lymphocyte subsets and NK cells in patients with colorectal cancer liver metastasis. Zhongguo Zhen jiu, 30, 10–12.

    PubMed  Google Scholar 

  • Zhao, R. H., & Zhu, Y. B. (2009). Observation on therapeutic effect of herb-partitioned moxibustion on fibromyalgia syndrome. Zhongguo Zhen Jiu, 29, 200–202.

    PubMed  Google Scholar 

  • Zhao, Z. (2008). Neural mechanism underlying acupuncture analgesia. Progress in Neurobiology, 85, 355–375.

    Article  PubMed  Google Scholar 

  • Zhong, J., Lin, C., Fang, G., Li, J. J., & Chen, P. (2010). Observation on therapeutic effect of plum-blossom needle combined with medicated thread moxibustion of traditional zhuang nationality medicine on postherpetic neuralgia. Zhongguo Zhen Jiu, 30, 773–776.

    PubMed  Google Scholar 

  • Zhou, E. H., Liu, H. R., Wu, H. G., Shi, Y., Wang, X. M., Tan, L. Y., et al. (2009). Suspended moxibustion relieves chronic visceral hyperalgesia via serotonin pathway in the colon. Neuroscience Letters, 451, 144–147.

    Article  PubMed  CAS  Google Scholar 

  • Zhu, Y. B. C., Zhuo, L. S., & Feng, W. Q. (2009a). Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats. Acupuncture Research, 34, 175–179.

    CAS  Google Scholar 

  • Zhu, Y., Liu, Q. Y., & Zhuo, L. S. (2009b). Influence of electroacupuncture of “Baihui” (GV 20) and “Sanyinjiao” (SP 6) on hippocampal 5-HT and AChE immuno-activity in chronic depression rats. Acupuncture Research, 34, 16–20.

    CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank Dr Lyn Lowry for her editorial assistance. This work was supported by NIH grant R21AT004113.

Author information

Authors and Affiliations

  1. Center for Integrative Medicine, School of Medicine, University of Maryland, Rm 8-22, MSTF, 685 West Baltimore Street, 21201, Baltimore, MD, USA

    Ruixin Zhang & Lixing Lao

Authors
  1. Ruixin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lixing Lao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ruixin Zhang .

Editor information

Editors and Affiliations

  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong SAR

    William C.S. Cho

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Zhang, R., Lao, L. (2012). Acupuncture and Moxibustion in Animal Models of Cancer. In: Cho, W. (eds) Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer. Evidence-based Anticancer Complementary and Alternative Medicine, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4833-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-4833-0_13

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-4832-3

  • Online ISBN: 978-94-007-4833-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation