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Angiogenic Activity of Sera from Interstitial Lung Disease Patients in Relation to Angiotensin-Converting Enzyme Activity

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Respiratory Regulation - The Molecular Approach

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

Abstract

The role of angiogenesis in the pathogenesis of interstitial lung diseases (ILD) is unknown. Angiotensin-converting enzyme (ACE) is a marker of sarcoidosis activity and may modulate angiogenesis. The aim of this study was to examine the relationship between ACE activity in ILD patients’ sera and their effect on microvessels formation in an in vivo model of leukocyte-induced angiogenesis. The study population consisted of 77 sarcoidosis patients, 22 idiopathic pulmonary fibrosis patients, 16 bird fanciers lung patients, eight silicosis patients and 14 healthy donors. Serum ACE activity was assayed by spectrophotometric method. As an angiogenic test, a leukocyte-induced angiogenesis assay in an animal model was used. Sera from interstitial lung disease patients significantly stimulated angiogenic activity of mononuclear cells compared with healthy donors (p < 0.001). The highest ACE serum activity was measured in sera from the silicosis patients, and lowest in sera from the sarcoidosis and IPF patients. A significantly lower serum ACE activity was detected in the bird fanciers lung patients. Serum angiogenic activity of ILD patients measured by angiogenesis index negatively correlated with ACE serum activity (r = ;−0.52; p < 0.01). This correlation was highest in the sarcoidosis group (r = −0.6; p < ). Sera from ILD patient constitute the source of factors modulating angiogenesis.

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Conflicts of interest: The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Family Medicine, Medical University of Warsaw, Banacha 1a St, 02-097, Warsaw, Poland

    T. M. Zielonka, K. Zycinska & M. H. Obrowski

  2. Department of Laboratory Diagnostics and Immunology, Institute of Tuberculosis and Lung Diseases, Plocka 26 St, 01-138, Warsaw, Poland

    M. Filewska & B. Bialas

  3. Laboratory of Molecular Diagnostics, Institute of Tuberculosis and Lung Diseases, Plocka 26 St, 01-138, Warsaw, Poland

    J. Chorostowska-Wynimko

  4. Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, Plocka 26 St, 01-138, Warsaw, Poland

    E. Radzikowska

  5. Department of Pathology, Biostructure Center, Medical University of Warsaw, Banacha 1a St, 02-097, Warsaw, Poland

    E. Skopinska-Rozewska

  6. Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, Marszalkowska 24 St, 00-576, Warsaw, Poland

    U. Demkow

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  1. T. M. Zielonka
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Correspondence to T. M. Zielonka .

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  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

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Zielonka, T.M. et al. (2013). Angiogenic Activity of Sera from Interstitial Lung Disease Patients in Relation to Angiotensin-Converting Enzyme Activity. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_27

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