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Signaling from the Adherens Junction

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Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 60))

Abstract

The cadherin/catenin complex organizes to form a structural Velcro that joins the cytoskeletal networks of adjacent cells. Functional loss of this complex arrests the development of normal tissue organization, and years of research have gone into teasing out how the physical structure of adhesions conveys information to the cell interior. Evidence that most cadherin-binding partners also localize to the nucleus to regulate transcription supports the view that cadherins serve as simple stoichiometric inhibitors of nuclear signals. However, it is also clear that cadherin-based adhesion initiates a variety of molecular events that can ultimately impact nuclear signaling. This chapter discusses these two modes of cadherin signaling in the context of tissue growth and differentiation.

*Abbye E. McEwen and David E. Escobar contributed equally

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Authors and Affiliations

  1. The Integrated Graduate Program in the Life Sciences, Department of Medicine, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA

    Abbye E. McEwen & David E. Escobar

  2. Northwestern University Feinberg School of Medicine, McGaw Pavilion Suite M-323 240 E Huron, 60611, Chicago, IL, USA

    Cara J. Gottardi

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  1. Abbye E. McEwen
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  2. David E. Escobar
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  3. Cara J. Gottardi
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Correspondence to Cara J. Gottardi .

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  1. , Cell and Systems Biology, University of Toronto, Harbord Street 25, Toronto, M5S 3G5, Ontario, Canada

    Tony Harris

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McEwen, A.E., Escobar, D.E., Gottardi, C.J. (2012). Signaling from the Adherens Junction. In: Harris, T. (eds) Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Subcellular Biochemistry, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4186-7_8

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