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Phosphoinositides in the Mammalian Endo-lysosomal Network

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Phosphoinositides II: The Diverse Biological Functions

Part of the book series: Subcellular Biochemistry ((SCBI,volume 59))

Abstract

The endo-lysosomal system is an interconnected tubulo-vesicular network that acts as a sorting station to process and distribute internalised cargo. This network accepts cargoes from both the plasma membrane and the biosynthetic pathway, and directs these cargos either towards the lysosome for degradation, the peri-nuclear recycling endosome for return to the cell surface, or to the trans-Golgi network. These intracellular membranes are variously enriched in different phosphoinositides that help to shape compartmental identity. These lipids act to localise a number of phosphoinositide-binding proteins that function as sorting machineries to regulate endosomal cargo sorting. Herein we discuss regulation of these machineries by phosphoinositides and explore how phosphoinositide-switching contributes toward sorting decisions made at this platform.

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Acknowledgements

Phosphoinositide research in the Cullen lab is supported by the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the Royal Society and the Swiss Science Federation. J.G. Carlton is a Wellcome Trust VIP and RCDF fellow. We thank all of our colleagues, past and present, for their intellectual input.

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  1. Henry Wellcome Integrated Signaling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, BS8 1TD, Bristol, United Kingdom

    Peter J. Cullen

  2. Department of Infectious Diseases, King’s College London, SE1 9RT and Division of Cancer Studies, SE1 1UL, London, United Kingdom

    Jeremy G. Carlton

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Correspondence to Peter J. Cullen .

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  1. , NICHD, National Institutes of Health, Convent Drive 49, Bethesda, 20892-4480, Maryland, USA

    Tamas Balla

  2. , Cancer- and Immunobiology, University of Basel, Mattenstrasse 28, Basel, 4058, Switzerland

    Matthias Wymann

  3. , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    John D. York

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Cullen, P.J., Carlton, J.G. (2012). Phosphoinositides in the Mammalian Endo-lysosomal Network. In: Balla, T., Wymann, M., York, J. (eds) Phosphoinositides II: The Diverse Biological Functions. Subcellular Biochemistry, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-3015-1_3

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