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Stem Cells and Calcium Signaling

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca2+ concentration [Ca2+]i. Acting as an intracellular messenger, Ca2+ has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca2+-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.

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Abbreviations

7TMS:

7-transmembrane segment receptor

Akt:

Protein kinase B

AM:

Amplitude modulation

BDNF:

Brain-derived neurotrophic factor

BMP:

Bone morphogenetic protein

BMP4:

Bone morphogenetic protein 4

CaMK:

Calcium/calmodulin dependent kinase protein

CaR:

Calcium sensing receptor

cAMP:

Cyclic adenosine monophosphate

cGMP:

Cyclic guanosine monophosphate

CREB:

Binding element responsive to cAMP

DAG:

Diacylglycerol

DKK1:

Dickkopf 1

ECC:

Embryonic carcimona cells

ECM:

Extracellular matrix

ELK:

Eph-related tyrosine kinase

ER:

Endoplasmatic reticulum

ERK:

Extracellular-signal-regulated kinase

ESC:

Embryonic stem cells

ExEn:

Extraembryonic endoderm

FGF:

Fibroblast growth factor

FGF1:

Fibroblast growth factor 1

FGF2:

Fibroblast growth factor 2

FL:

Fluorescein

FM:

Frequency modulation

FZD:

Frizzled

GFP:

Green fluorescent protein

GPCR:

G protein-coupled receptor

hESC:

Human embryonic stem cell

hHSC:

Human hematopoietic stem cell

hMSC:

Human mesenchymal stem cell

HSC:

Hematopoietic stem cell

ICM:

Inner cell mass

iMEF:

Mitotically inactivated embryonic fibroblast

IP3:

Inositol 1,4,5-triphosphate

IP3Rs:

Inositol 1,4,5-triphosphate receptors

iPSC:

Induced pluripotent stem cell

IVF:

in vitro fertilized

JAK:

Janus kinase

Klf4:

Gut-enriched Krüppel-like factor

LIF:

Leukemia inhibitory factor

LPA:

Lysophosphatidic acid

MKK3:

Mitogen-activated Protein Kinase Kinase 3

MAP:

Microtubule-associated protein

MAP1B:

Protein association with the microtubule 1B

MAP2:

Protein associated with type 2 microtubule

MAPK:

Pathways of mitogen-activated protein kinases

MAPKK:

MAP kinase kinase

mESC:

Mouse embryonic stem cell

NAAD:

Nicotinic Acid Adenine Dinucleotide

NANOG:

Nanog homeobox

NFAT:

Nuclear factors of activated T-cells

NFκB:

Nuclear factor κBl

NSC:

Neural stem cell

OAP:

Oct/octamer-associated protein

OCT-4:

Octamer-binding transcription factor 4

PI3K:

Phosphoinositide Kinase-3

PIP2:

Phosphatidylinositol 4,5-biphosphate

PKA:

Protein kinase A

PKC:

Protein kinase C

PLC:

Phospholipase C

PSC:

Pluripotent stem cell

Ras:

Rat sarcoma similar to G protein GTPase

Rcn2:

Reticulocalbin-2

RyR:

Ryanodine receptors

ROC:

Receptor-operated channels

RTKs:

Receptors tyrosine kinase

Stk40:

Serine/threonine kinase 40

SOX2:

Sex determining region Y box 2

SR:

Sarcoplasmatic reticulum

SOC:

Store-operated channels

SSC:

Somatic stem cell

STAT3:

Signal transducer and activator of transcription 3

Stk40:

Serine/threonine kinase 40

TBX3:

T-box transcription factor

Tc:

Tetracycline

TGF-β:

Transforming growth factor-β

TSC:

Tumor stem cell

VOCC:

Voltage-operated calcium channels

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Acknowledgements

This work was supported by Instituto Nacional de Ciência e Tecnologia de Nanomateriais de Carbono, CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Brazil. R.R.R, L.O.L., K.N.G., and D.A.G. are grateful for grants from CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais), and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

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Authors and Affiliations

  1. Nanomaterials Laboratory, Department of Physics, Institute of Exact Sciences, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil

    Katia N. Gomes & Rodrigo R. Resende

  2. Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil

    Dawidson A. Gomes

  3. Universidade Federal de São João Del Rei Campus Alto Paraopeba, 31270-901, Belo Horizonte, MG, Brazil

    Fernanda M. P. Tonelli, Anderson K. Santos, Saulo L. da Silva, Luiz O. Ladeira & Rodrigo R. Resende

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  1. Fernanda M. P. Tonelli
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Correspondence to Rodrigo R. Resende .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Tonelli, F.M.P. et al. (2012). Stem Cells and Calcium Signaling. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_40

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