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Photodynamic Therapy

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Radiation Damage in Biomolecular Systems

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Treatments based on absorption of electromagnetic radiation may be categorized according to the photon wavelength range. On the one hand, radiotherapy is based on X-rays delivery to tissues and is widely spread and recognized for cancer treatment. On the other hand, photodynamic therapy (PDT) involves low energy radiation in the visible and near infrared range in combination with a drug referred to as the photosensitizer. A short overview of conventional radiotherapy and accelerator-based therapy is first presented. Then PDT is introduced and its mechanisms are reviewed along with the factors affecting its outcome. The domains of application of this therapy are presented through a discussion of the most used photosentizers. Finally we present new developments in the field that would permit the combination of potentialized radiotherapy and photodynamic therapy.

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Authors and Affiliations

  1. Synchrotron SOLEIL, L’Orme des Merisiers, 911 92, Gif sur Yvette, France

    Slávka Kaščáková, Alexandre Giuliani, Frédéric Jamme & Matthieu Refregiers

  2. Cepia, Institut National de la Recherche Agronomique, 716 27, 443 16, Nantes, France

    Alexandre Giuliani & Frédéric Jamme

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  1. Slávka Kaščáková
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  2. Alexandre Giuliani
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  3. Frédéric Jamme
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  4. Matthieu Refregiers
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Correspondence to Alexandre Giuliani .

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  1. , Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113-bis, Madrid, 28006, Spain

    Gustavo García Gómez-Tejedor

  2. Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113bis, Madrid, 28006, Spain

    Martina Christina Fuss

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Kaščáková, S., Giuliani, A., Jamme, F., Refregiers, M. (2012). Photodynamic Therapy. In: García Gómez-Tejedor, G., Fuss, M. (eds) Radiation Damage in Biomolecular Systems. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2564-5_27

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  • DOI: https://doi.org/10.1007/978-94-007-2564-5_27

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