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Myristica fragrans

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Abstract

Myristica aromatica Sw., Myristica laurifolia var. lanceolata Hook.f., Myristica moschata Thunb., Myristica officinalis L. f.

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Selected References

  • Anggakusuma, Yanti, Hwang JK (2010) Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. J Dermatol Sci 57(2):114–122

    Google Scholar 

  • Arulmozhi DK, Kurian R, Veeranjaneyulu A, Bodhankar SL (2007) Antidiabetic and antihyperlipidemic effects of Myristica fragrans in animal models. Pharm Biol 45(1):64–68

    Article  Google Scholar 

  • Backer CA, Bakhuizen van den Brink RC Jr (1963) Flora of Java, (spermatophytes only), vol 1. Noordhoff, Groningen, 648 pp

    Google Scholar 

  • Barrowman JA, Bennett A, Hillebrand P, Rolles K, Pollock DJ, Wright T (1975) Diarrhoea in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg. Br Med J 3(5974):11–12

    Article  PubMed  CAS  Google Scholar 

  • Bennett A, Stamford IF, Tavares IA, Jacobs S, Capasso F, Mascolo N, Autore G, Romano V, Di Carlo G (1988) The biological activity of eugenol, a major constituent of nutmeg (Myristica fragrans): studies on prostaglandins, the intestine and other tissues. Phytother Res 2:124–130

    Article  CAS  Google Scholar 

  • Beyer J, Ehlers D, Maurer HH (2006) Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther Drug Monit 28(4):568–575

    Article  PubMed  CAS  Google Scholar 

  • Bhamarapravati S, Pendland SL, Mahady GB (2003) Extracts of spice and food plants from Thai traditional medicine inhibit the growth of the human carcinogen Helicobacter pylori. In Vivo 17(6):541–544

    PubMed  CAS  Google Scholar 

  • Burkill IH (1966) A dictionary of the economic products of the Malay Peninsula. Revised reprint, 2 volumes. Ministry of Agriculture and Co-operatives, Kuala Lumpur, vol 1 (A-H), p 1–1240, vol 2 (I-Z), pp 1241–2444

    Google Scholar 

  • Chatterjee S, Niaz Z, Gautam S, Adhikari S, Variyar PS, Sharma A (2007) Antioxidant activity of some phenolic constituents from green pepper (Piper nigrum L.) and fresh nutmeg mace (Myristica fragrans). Food Chem 101(2):515–523

    Article  CAS  Google Scholar 

  • Chaubey MK (2008) Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae). J Oleo Sci 57(3):171–179

    Article  PubMed  CAS  Google Scholar 

  • Checker R, Chatterjee S, Sharma D, Gupta S, Variyar P, Sharma A, Poduval TB (2008) Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol 8(5):661–669

    Article  PubMed  CAS  Google Scholar 

  • Chhabra SK, Rao AR (1994) Transmammary modulation of xenobiotic metabolizing enzymes in liver of mouse pups by mace (Myristica fragrans Houtt.). J Ethnopharmacol 42(3):169–177

    Article  PubMed  CAS  Google Scholar 

  • Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, Lowanitchapat A, Sa-nguanmoo P, Poovorawan Y (2007) Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai 90(11):2422–2428

    PubMed  Google Scholar 

  • Cho JY, Choi GJ, Son SW, Jang KS, Lim HK, Lee SO, Sung ND, Cho KY, Kim JC (2007) Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. Pest Manag Sci 63(9):935–940

    Article  PubMed  CAS  Google Scholar 

  • Cho Y, Kim KH, Shim JS, Hwang JK (2008) Inhibitory effects of macelignan isolated from Myristica fragrans Houtt. on melanin biosynthesis. Biol Pharm Bull 31(5):986–989

    Article  PubMed  CAS  Google Scholar 

  • Choo LC, Wong SM, Liew KY (1999) Essential oil of nutmeg pericarp. J Sci Food Agric 79(13):1954–1957

    Article  CAS  Google Scholar 

  • Chung JY, Choo JH, Lee MH, Hwang JK (2006) Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 13(4):261–266

    Article  PubMed  CAS  Google Scholar 

  • Cui CA, Jin DQ, Hwang YK, Lee IS, Hwang JK, Ha I, Han JS (2008) Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neurosci Lett 448(1):110–114

    Article  PubMed  CAS  Google Scholar 

  • Daniel D (1994) Nutmeg and derivatives. Food and Agriculture Organization of the United Nations, Rome, Working Paper MISC/94/7

    Google Scholar 

  • Davis DV, Cooks RG (1982) Direct characterization of nutmeg constituents by mass spectrometry-mass spectrometry. J Agric Food Chem 30(3):495–504

    Article  CAS  Google Scholar 

  • Dhingra D, Sharma A (2006) Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J Med Food 9(1):84–89

    Article  PubMed  Google Scholar 

  • Dhingra D, Parle M, Kulkarni SK (2006) Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. J Med Food 9(2):281–283

    Article  PubMed  CAS  Google Scholar 

  • Duan L, Tao HW, Hao XJ, Gu QQ, Zhu WM (2009) Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans. Planta Med 75(11):1241–1245

    Article  PubMed  CAS  Google Scholar 

  • Duke JA, Bogenschutz-Godwin MJ, DuCellier J, Duke PA (2002) CRC handbook of medicinal plants, 2nd edn. CRC, Boca Raton, 936 pp

    Google Scholar 

  • El-Alfy AT, Wilson L, ElSohly MA, Abourashed EA (2009) Towards a better understanding of the psychopharmacology of nutmeg: activities in the mouse tetrad assay. J Ethnopharmacol 126(2):280–286

    Article  PubMed  Google Scholar 

  • Facciola S (1990) Cornucopia: a source book of edible plants. Kampong Publications, Vista, 677 pp

    Google Scholar 

  • Firouzi R, Shekarforoush SS, Nazer AH, Borumand Z, Jooyandeh AR (2007) Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken. J Food Prot 70(11):2626–2630

    PubMed  CAS  Google Scholar 

  • Flach M, Tjeenk Willink M (1999) Myristica fragrans Houtt. In: de Guzman CC, Siemonsma JS (eds) Plant resources of South-East Asia no. 13: Spices. Prosea Foundation, Bogor, pp 143–148

    Google Scholar 

  • Foundation for Revitalisation of Local Health Traditions (2008) FRLHT Database. http://envis.frlht.org

  • Fras I, Friedman JJ (1969) Hallucinogenic effects of nutmeg in adolescent. NY State J Med 69(3):463–465

    CAS  Google Scholar 

  • Gonçalves JL, Lopes RC, Oliveira DB, Costa SS, Miranda MM, Romanos MT, Santos NS, Wigg MD (2005) In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea. J Ethnopharmacol 99(3):403–407

    Article  PubMed  Google Scholar 

  • Grover JK, Khandkar S, Vats V, Dhunnoon Y, Das D (2002) Pharmacological studies on Myristica fragrans – antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol 24(10):675–680

    Article  PubMed  CAS  Google Scholar 

  • Gupta S, Yadava JNS, Mehrotra R, Tandon JS (1992) Anti-diarrhoea1 profile of an extract and some fractions from Myristica fragrans (Nut-meg) on Escherichia coli enterotoxin-induced secretory response. Pharm Biol 30(3):179–183

    Article  Google Scholar 

  • Hada S, Hattori M, Tezuka Y, Kikuchi T, Namba T (1988) New neolignans and lignans from the aril of Myristica fragrans. Phytochem 27(2):563–8

    Google Scholar 

  • Hallström H, Thuvander A (1997) Toxicological evaluation of myristicin. Nat Toxins 5(5):186–192

    Article  PubMed  Google Scholar 

  • Han KL, Choi JS, Lee JY, Song J, Joe MK, Jung MH, Hwang JK (2008) Therapeutic potential of peroxisome proliferators–activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 7(3):737–745

    Article  CAS  Google Scholar 

  • Hang X, Yang XW (2007) GC-MS analysis of essential oil from nutmeg processed by different traditional methods. Zhongguo Zhong Yao Za Zhi 32(16):1669–1675

    PubMed  Google Scholar 

  • Hattori M, Yang XW, Shu YZ, Kakiuchi N, Tezuka Y, Kikuchi T, Namba T (1988) New constituents of the aril of Myristica fragrans. Chem Pharm Bull 36(2):648–653

    Article  CAS  Google Scholar 

  • Hussain SP, Rao AR (1991) Chemopreventive action of mace (Myristica fragrans, Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice. Cancer Lett 56(3):231–234

    Article  PubMed  CAS  Google Scholar 

  • Im YB, Ha I, Kang KW, Lee MY, Han HK (2009) Macelignan: a new modulator of p-glycoprotein in multidrug-resistant cancer cells. Nutr Cancer 61(4):538–543

    Article  PubMed  CAS  Google Scholar 

  • Jaiswal P, Kumar P, Singh VK, Singh DK (2009) Biological effects of Myristica fragrans. Ann Rev Biomed Sci 11:21–29

    Google Scholar 

  • Jaiswal P, Kumar P, Singh VK, Singh DK (2010) Enzyme inhibition by molluscicidal components of Myristica fragrans Houtt. in the nervous tissue of snail Lymnaea acuminata. Enzyme Res, article 478746

    Google Scholar 

  • Jan M, Faqir F, Qureshi H, Malik SA, Mughal MA (2004) Evaluation of effects of extract from seeds of Myristica fragrans on volume and acidity of stimulated gastric secretion, liver and kidney function. J Postgrad Med Inst 18:644–650

    Google Scholar 

  • Jan M, Faqir F, Hamida, Mughal MA (2005) Comparison of effects of extract of Myristica fragrans and verapamil on the volume and acidity of carbachol induced gastric secretion in fasting rabbits. J Ayub Med Coll Abbottabad 17(2):69–71

    Google Scholar 

  • Jannu LN, Hussain SP, Rao AR (1991) Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice. Cancer Lett 56(1):59–63

    Article  PubMed  CAS  Google Scholar 

  • Janssen J, Laeckman GM (1990) Nutmeg oil: identification and quantification of its most active of platelet constituents as inhibitors aggregation. J Ethnopharmacol 29:179–188

    Article  Google Scholar 

  • Javaregowda PK, Hong YK, Kim SM, Hong YG (2010) In vitro and in vivo analysis of macelignan induced toxicity on heart. FASEB J 24:lb557

    Google Scholar 

  • Jin DQ, Lim CS, Hwang JK, Ha I, Han JS (2005) Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells. Biochem Biophys Res Commun 331(4):1264–1269

    Article  PubMed  CAS  Google Scholar 

  • Joseph J (1980) The nutmeg – its botany, agronomy, production, composition, and uses. J Plant Crops 8(2):61–72

    Google Scholar 

  • Juhász L, Kürti L, Antus S (2000) Simple synthesis of benzofuranoid neolignans from Myristica fragrans. J Nat Prod 63(6):866–870

    Article  PubMed  CAS  Google Scholar 

  • Jukić M, Politeo O, MiloÅ¡ M (2006) Chemical composition and antioxidant effect of free volatile aglycones from nutmeg (Myristica fragrans Houtt.) compared to its essential oil. Croatica Chem Acta 79(2):209–214

    Google Scholar 

  • Jung WC, Jang YS, Hieu TT, Lee CK, Ahn YJ (2007) Toxicity of Myristica fagrans seed compounds against Blattella germanica (Dictyoptera: Blattellidae). J Med Entomol 44(3):524–529

    Article  PubMed  CAS  Google Scholar 

  • Kasahara H, Miyazawa M, Kameoka H (1995) Absolute configuration of 8-O-4′-neolignans from Myristica fragrans. Phytochemistry 40(5):1515–1517

    Article  CAS  Google Scholar 

  • Kim YB, Park IY, Shin KH (1991) The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res 14(1):1–6

    Article  PubMed  CAS  Google Scholar 

  • Kim HJ, Chen F, Wang X, Wang Y, McGregor J, Jiang YM (2010) Characterization of antioxidants in nutmeg (Myristica fragrans Houttuyn) oil. In: Qian MC, Rimando AM (eds) Flavour and health benefits of small fruits, vol 1035., pp 239–252, Chapter 15

    Chapter  Google Scholar 

  • Kimura Y, Ito H, Hatano T (2010) Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity. Biol Pharm Bull 33(12):1977–1982

    Article  PubMed  CAS  Google Scholar 

  • Kumari MV, Rao AR (1989) Effects of mace (Myristica fragrans, Houtt.) on cytosolic glutathione S-transferase activity and acid soluble sulfhydryl level in mouse liver. Cancer Lett 46(2):87–91

    Article  PubMed  CAS  Google Scholar 

  • Kwon HS, Kim MJ, Jeong HJ, Yang MS, Park KH, Jeong TS, Lee WS (2008) Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds. Bioorg Med Chem Lett 18:194–198

    Article  PubMed  CAS  Google Scholar 

  • Lee KT, Kim BJ, Kim JH, Heo MY, Kim HP (1997) Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation. Int J Cosmet Sci 19(6):291–298

    Article  PubMed  CAS  Google Scholar 

  • Lee KK, Kim JH, Cho JJ, Choi JD (1999) Effects of 150 plant extracts on elastase activity, and their anti-inflammatory effects. Int J Cosmet Sci 21(2):71–82

    Article  PubMed  CAS  Google Scholar 

  • Lee BK, Kim JH, Jung JW, Choi JW, Han ES, Lee SH, Ko KH, Ryu JH (2005) Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. Toxicol Lett 157:49–56

    Article  PubMed  CAS  Google Scholar 

  • Lee SU, Shim KS, Ryu SY, Min YK, Kim SH (2009) Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation. Planta Med 75(2):152–157

    Article  PubMed  CAS  Google Scholar 

  • Li F, Yang XW (2007) Three new neolignans from the aril of Myristica fragrans. Helv Chim Acta 90:1491–1496

    Article  CAS  Google Scholar 

  • Li F, Yang XW (2008a) Biotransformation of myrislignan by rat liver microsomes in vitro. Phytochemistry 69(3):765–771

    Article  PubMed  CAS  Google Scholar 

  • Li F, Yang XW (2008b) Simultaneous determination of diastereomers (+)-licarin A and isolicarin A from Myristica fragrans in rat plasma by HPLC and its application to their pharmacokinetics. Planta Med 74(8):880–884

    Article  PubMed  CAS  Google Scholar 

  • Ma J, Hwang YK, Cho WH, Han SH, Hwang JK, Han JS (2009) Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells. Biol Pharm Bull 32(6):1085–1090

    Article  PubMed  CAS  Google Scholar 

  • Maeda A, Shin’ichi T, Tomo A, Hisayuki T, Masato N (2006) Physiological activities of Myristica fragrans Houtt. Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu 50:337–339, In Japanese

    Google Scholar 

  • Maeda A, Tanimoto S, Abe T, Kazama S, Tanizawa H, Nomura M (2008) Chemical constituents of Myristica fragrans Houttuyn seed and their physiological activities. Yakugaku Zasshi 128(1):129–133, In Japanese

    Article  PubMed  CAS  Google Scholar 

  • Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR (2005) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res 19(11):988–991

    Article  PubMed  Google Scholar 

  • Malti JE, Bourhim N, Amarouch H (2008) Ttoxicity and antibacterial effect of mace of Myristica fragrans used in Moroccan gastronomy: biochemical and histological impact. J Food Safety 28(3):422–441

    Article  Google Scholar 

  • Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K (2003) Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury. J Agric Food Chem 51(6):1560–1565

    Article  PubMed  CAS  Google Scholar 

  • Muchtaridi, Subarnas A, Apriyantono A, Mustarichie R (2010). Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice. Int J Mol Sci 11:4771–4781

    Google Scholar 

  • Narasimhan B, Dhake AS (2006) Antibacterial principles from Myristica fragrans seeds. J Med Food 9(3):395–399

    Article  PubMed  CAS  Google Scholar 

  • Nguyen PH, Le TV, Kang HW, Chae J, Kim SK, Kwon KI, Seo DB, Lee SJ, Oh WK (2010) AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett 20(14):4128–4131

    Article  PubMed  CAS  Google Scholar 

  • Ochse JJ, Bakhuizen van den Brink RC (1980) Vegetables of the Dutch Indies, 3rd edn. Ascher, Amsterdam, 1016 pp

    Google Scholar 

  • Olajide OA, Ajayi FF, Ekhelar AI, Awe SO, Makinde JM, Alada ARA (1999) Biological effects of Myristica fragrans (nutmeg) extract. Phytother Res 13(4):344–345

    Article  PubMed  CAS  Google Scholar 

  • Olaleye MT, Akinmoladun AC, Akindahunsi AA (2006) Antioxidant properties of Myristica fragrans (Houtt) and its effect on selected organs of albino rats. African J Biotechnol 5(13):1274–1278

    Google Scholar 

  • Orabi KY, Mossa JS, el-Feraly FS (1991) Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J Nat Prod 54(3):856–859

    Article  PubMed  CAS  Google Scholar 

  • Ozaki Y, Soedigdo S, Wattimena YR, Suganda AG (1989) Antiinflammatory effect of mace, aril of Myristica fragrans Houtt. and its active principles. Japan J Pharmco 49(2):155–163

    Article  CAS  Google Scholar 

  • Park S, Lee DK, Yang CH (1998) Inhibition of fos-jun-DNA complex formation by dihydroguaiaretic acid and in vitro cytotoxic effects on cancer cells. Cancer Lett 127(1–2):23–28

    Article  PubMed  CAS  Google Scholar 

  • Parle M, Dhingra D, Kulkarni SK (2004) Improvement of mouse memory by Myristica fragrans seeds. J Med Food 7(2):156–161

    Article  PubMed  Google Scholar 

  • Porcher MH et al (1995–2020) Searchable World Wide Web multilingual multiscript plant name database. The University of Melbourne, Australia. http://www.plantnames.unimelb.edu.au/Sorting/Frontpage.html

  • Purseglove JW (1968) Tropical crops: dicotyledons 1 & 2. Longman, London, 719 pp

    Google Scholar 

  • Purseglove JW, Brown EG, Green CL, Robbins SRJ (1981) Spices (Tropical agriculture series), vol 2. Longman, London, 813 pp

    Google Scholar 

  • Qiu Q, Zhang G, Sun X, Liu X (2004) Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation. Zhong Yao Cai 27(11):823–826, In Chinese

    PubMed  Google Scholar 

  • Ram A, Lauria P, Gupta R, Sharma VN (1996) Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits. J Ethnopharmacol 55(1):49–53

    Article  PubMed  CAS  Google Scholar 

  • Senthilkumar N, Varma P, Gurusubramanian G (2009) Larvicidal and adulticidal activities of some medicinal plants against the malarial vector, Anopheles stephensi (Liston). Parasitol Res 104(2):237–244

    Article  PubMed  CAS  Google Scholar 

  • Sharma A, Mathur R, Dixit VP (1995) Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract. Indian J Physiol Pharmacol 39(4):407–410

    PubMed  CAS  Google Scholar 

  • Sharma M, Kumar M (2007) Radioprotection of Swiss albino mice by Myristica fragrans Houtt. J Radiat Res (Tokyo) 48(2):135–41

    Google Scholar 

  • Sherry CJ, Ray LE, Herron RE (1982) The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans). J Ethnopharmacol 6(1):661–666

    Article  Google Scholar 

  • Shukla J, Tripathi SP, Chaubey MK (2008) Toxicity of Myristica fragrans and Ilicium verum essential oils against flour beetle Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) Electr. J Environ Agric Food Chem 7(7):3059–3064

    CAS  Google Scholar 

  • Sinclair J (1958) A revision of the Malayan Myristicaceae. Gard Bul Singapore 16:205–472

    Google Scholar 

  • Sinclair J (1968) The genus Myristica in Malesia and outside Malesia. Gard Bul Singapore 23:1–540

    Google Scholar 

  • Singh G, Marimuthu P, de Heluani CS, Catalan C (2005) Antimicrobial and antioxidant potentials of essential oil and acetone extract of Myristica fragrans Houtt. (aril part). J Food Sci 70(2):M141–M148

    Article  CAS  Google Scholar 

  • Smith-Palmer A, Stewartt J, Fyfe L (2002) Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils. J Med Microbiol 51(7):567–574

    PubMed  CAS  Google Scholar 

  • Sohn JH, Han KL, Choo JH, Hwang JK (2007) Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage. Biofactors 29(1):1–10

    Article  PubMed  CAS  Google Scholar 

  • Sohn JH, Han KL, Kim JH, Rukayadi Y, Hwang JK (2008) Protective effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull 31(2):273–277

    Article  PubMed  CAS  Google Scholar 

  • Sonavane GS, Palekar RC, Kasture VS, Kasture SB (2002a) Anticonvulsant and behavioural actions of Myristica fragrans seeds. Indian J Pharm 34(5):332–338

    Google Scholar 

  • Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB (2002b) Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav 71(1):239–244

    Article  PubMed  CAS  Google Scholar 

  • Spricigo CB, Pinto LT, Bolzan A, Novais AF (1999) Extraction of essential oil and lipids from nutmeg by liquid carbon dioxide. J Supercritical Fluids 15:253–259

    Article  CAS  Google Scholar 

  • Tajuddin AS, Latif A, Qasmi IA (2003) Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L.) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med 3:6

    Article  PubMed  CAS  Google Scholar 

  • Tajuddin AS, Latif A, Qasmi IA, Amin KM (2005) An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med 5:16

    Article  PubMed  CAS  Google Scholar 

  • Takikawa A, Abe K, Yamamoto M, Ishimaru S, Yasui M, Okubo Y, Yokoigawa K (2002) Antimicrobial activity of nutmeg against Escherichia coli O157. J Biosci Bioeng 94:315–320

    PubMed  CAS  Google Scholar 

  • Tomaino A, Cimino F, Zimbalatti V, Venuti V, Sulfaro V, De Pasquale A, Saija A (2005) Influence of heating on antioxidant activity and the chemical composition of some spice essential oils. Food Chem 89(4):549–554

    Article  CAS  Google Scholar 

  • Truitt EB Jr, Duritz G, Ebersberger EM (1963) Evidence of monoamine oxidase inhibition by myristicin and nutmeg. Proc Soc Exp Biol Med 112:647–650

    PubMed  CAS  Google Scholar 

  • U.S. Department of Agriculture, Agricultural Research Service (2010) USDA National Nutrient Database for Standard Reference, Release 23. Nutrient Data Laboratory Home Page. http://www.ars.usda.gov/ba/bhnrc/ndl

  • Valente VMM, Jham GN, Dhingra OD, Ghiviriga I (2011) Composition and antifungal activity of the Brazilian Myristica fragrans Houtt essential oil. J Food Safety 31(2):197–202

    Article  CAS  Google Scholar 

  • Van Gils C, Cox PA (1994) Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol 42:117–124

    Article  PubMed  Google Scholar 

  • Variyar PS, Chatterjee S, Sajilata MG, Singhal RS, Sharma A (2008) Natural existence of 2-alkylcyclobutanones. J Agric Food Chem 56(24):11817–11823

    Article  PubMed  CAS  Google Scholar 

  • Voelker TA, Jones A, Cranmer AM, Davies HM, Knutzon DS (1997) Broad-range and binary-range acyl-acyl-carrier protein thioesterases suggest an alternative mechanism for medium-chain production in seeds. Plant Physiol 114(2):669–677

    Article  PubMed  CAS  Google Scholar 

  • Wahab A, Ul Haq R, Ahmed A, Khan RA, Raza M (2009) Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytother Res 23(2):153–158

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Yang XW, Tao HY, Liu HX (2004) GC-MS analysis of essential oils from seeds of Myristica fragrans in Chinese market. Zhongguo Zhong Yao Za Zhi 29:339–342, In Chinese

    PubMed  CAS  Google Scholar 

  • Weiss G (1960) Hallucinogenic and narcotic-like effects of powdered Myristica (nutmeg). Psychiatr Q 34(1):346–356

    PubMed  CAS  Google Scholar 

  • Weiss EA (1997) Myristicaceae. Essential oil crops. CAB International, Wallingford, pp 214–234, Chapter 7

    Google Scholar 

  • Yadav AS, Bhatnagar D (2007a) Free radical scavenging activity, metal chelation and antioxidant power of some of the Indian spices. Biofactors 31(3–4):219–227

    Article  PubMed  CAS  Google Scholar 

  • Yadav AS, Bhatnagar D (2007b) Modulatory effect of spice extracts on iron-induced lipid peroxidation in rat liver. Biofactors 29(2–3):147–157

    Article  PubMed  CAS  Google Scholar 

  • Yang S, Na MK, Jang JP, Kim KA, Kim BY, Sung NJ, Oh WK, Ahn JS (2006) Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans. Phytother Res 20(8):680–682

    Article  PubMed  CAS  Google Scholar 

  • Yang XW, Huang X, Ahmat M (2008) New neolignan from seed of Myristica fragrans. Zhongguo Zhong Yao Za Zhi 33(4):397–402, In Chinese

    PubMed  CAS  Google Scholar 

  • Yang XW, Huang X, Ma L, Wu Q, Xu W (2010) The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model. Planta Med 76(14):1587–1591

    Article  PubMed  CAS  Google Scholar 

  • Yanti, Rukayadi Y, Kim KH, Hwang JK (2008) In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res 22(3):308–312

    Google Scholar 

  • Yuan ZM, Wang J, Lv J, Jia TZ (2006) Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS. Zhongguo Zhong Yao Za Zhi 31(9):737–739, In Chinese

    PubMed  CAS  Google Scholar 

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  1. Canberra, ACT, Australia Norriss Street 49 2905 Chisholm Aust Capital Terr, Australia

    Dr. T. K. Lim

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© 2012 Springer Science+Business Media B.V.

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Lim, T.K. (2012). Myristica fragrans. In: Edible Medicinal And Non Medicinal Plants. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2534-8_80

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