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Cartilage Injuries: Role of Implantation of Human Stem/Progenitor Cells

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Stem Cells and Cancer Stem Cells,Volume 3

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

Abstract

As articular cartilage has very limited self-repair capability, the repair and regeneration of damaged cartilage is a major challenge. This chapter aims to present the potential seed cell sources that can be utilized for cartilage regeneration, such as autologous chondrocytes (hACs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). One of the promising candidate is cartilage stem/progenitor cell (CSPCs). Current scientific research has demonstrated the existence, definition and niche of CSPCs. The clinical applications of CSPCs show much promise for cartilage regeneration.

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References

  • Alsalameh S, Amin R, Gemba T, Lotz M (2004) Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 50:1522–1532

    Article  PubMed  Google Scholar 

  • Dowthwaite GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJ, Haughton L, Bayram Z, Boyer S, Thomson B, Wolfe MS, Archer CW (2004) The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117:889–897

    Article  PubMed  CAS  Google Scholar 

  • Fickert S, Fiedler J, Brenner RE (2004) Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers. Arthritis Res Ther 6:R422–432

    Article  PubMed  CAS  Google Scholar 

  • Grogan SP, Miyaki S, Asahara H, D’Lima DD, Lotz. MK (2009) Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 11:R85

    Article  PubMed  Google Scholar 

  • Hattori S, Oxford C, Reddi AH (2007) Identification of superficial zone articular chondrocyte stem/progenitor cells. Biochem Biophys Res Commun 358:99–103

    Article  PubMed  CAS  Google Scholar 

  • Hayes AJ, Tudor D, Nowell MA, Caterson B, Hughes CE (2008) Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. J Histochem Cytochem 56:125–138

    Article  PubMed  CAS  Google Scholar 

  • Henson FM, Bowe EA, Davies ME (2005) Promotion of the intrinsic damage-repair response in articular cartilage by fibroblastic growth factor-2. Osteoarthritis Cartilage 13:537–544

    Article  PubMed  CAS  Google Scholar 

  • Hiramatsu K, Sasagawa S, Outani H, Nakagawa K, Yoshikawa H, Tsumaki N (2011) Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest 121:640–657

    Article  PubMed  CAS  Google Scholar 

  • Hiraoka K, Grogan S, Olee T, Lotz M (2006) Mesenchymal progenitor cells in adult human articular cartilage. Biorheology 43:447–454

    PubMed  Google Scholar 

  • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460:1132–1135

    Article  PubMed  CAS  Google Scholar 

  • Hunter W (1743) Of the structure and diseases of articulating cartilages. Phil Trans 470:514–521

    Google Scholar 

  • Jiang YZ, Zhang SF, Qi YY, Wang LL, Ouyang HW (2010) Cell transplantation for articular cartilage defects: principles of past, present and future practice. Cell Transplant 20:593–607

    Google Scholar 

  • Karlsson C, Lindahl A (2009) Articular cartilage stem cell signalling. Arthritis Res Ther 11:121

    Article  PubMed  Google Scholar 

  • Khan IM, Williams R, Archer CW (2009) One flew over the progenitor’s nest: migratory cells find a home in osteoarthritic cartilage. Cell Stem Cell 4:282–284

    Article  PubMed  CAS  Google Scholar 

  • Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N (2009) Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 4:324–335

    Article  PubMed  CAS  Google Scholar 

  • Li L, Clevers H (2010) Coexistence of quiescent and active adult stem cells in mammals. Science 327:542–545

    Article  PubMed  CAS  Google Scholar 

  • Lotz MK, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D’Lima D (2010) Cartilage cell clusters. Arthritis Rheum 62:2206–2218

    Article  PubMed  Google Scholar 

  • Mats Brittberg PA, Gambardella R, Hangody L, Haruselmann HJ, Jakob RP, Levine D, Lohmander S, Mandelbaum BR, Peterson L, Staubli H-U (2000) ICRS cartilage injury evaluation package. http://www.cartilage.org

  • Mimeault M, Batra SK (2007) Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications. Cancer Metastasis Rev 26:203–214

    Article  PubMed  CAS  Google Scholar 

  • Morrison SJ, Shah NM, Anderson DJ (1997) Regulatory mechanisms in stem cell biology. Cell 88:287–298

    Article  PubMed  CAS  Google Scholar 

  • Ozbey O, Sahin Z, Acar N, Ustunel I (2010) Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus. Histol Histopathol 25:1437–1445

    PubMed  Google Scholar 

  • Spangrude GJ, Heimfeld S, Weissman IL (1988) Purification and characterization of mouse hematopoietic stem cells. Science 241:58–62

    Article  PubMed  CAS  Google Scholar 

  • Thornemo M, Tallheden T, Sjogren Jansson E, Larsson A, Lovstedt K, Nannmark U, Brittberg M, Lindahl A (2005) Clonal populations of chondrocytes with progenitor properties identified within human articular cartilage. Cells Tissues Organs 180:141–150

    Article  PubMed  CAS  Google Scholar 

  • Thorogood PV, Hall BK (1976) The use of variable lactate/malic dehydrogenase ratios to distinguish between progenitor cells of cartilage and bone in the embryonic chick. J Embryol Exp Morphol 36:305–313

    PubMed  CAS  Google Scholar 

  • Togo T, Utani A, Naitoh M, Ohta M, Tsuji Y, Morikawa N, Nakamura M, Suzuki S (2006) Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction. Lab Invest 86:445–457

    Article  PubMed  CAS  Google Scholar 

  • Ustunel I, Ozenci AM, Sahin Z, Ozbey O, Acar N, Tanriover G, Celik-Ozenci C, Demir R (2008) The immunohistochemical localization of notch receptors and ligands in human articular cartilage, chondroprogenitor culture and ultrastructural characteristics of these progenitor cells. Acta Histochem 110:397–407

    Article  PubMed  Google Scholar 

  • Wang LL, Jiang YZ, Qi YY, Chen X, Lu P, Song XH, Zou XH, Ouyang HW (2008) Human embryonic stem cell-derived mesenchymal stem cells promote cartilage repair by paracrine action. In: 8th World Congress of the International Cartilage Repair Society, May 23–26, 2008, Miami, p 170

    Google Scholar 

  • Williams R, Khan IM, Richardson K, Nelson L, McCarthy HE, Analbelsi T, Singhrao SK, Dowthwaite GP, Jones RE, Baird DM, Lewis H, Roberts S, Shaw HM, Dudhia J, Fairclough J, Briggs T, Archer CW (2010) Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS One 5:e13246

    Article  PubMed  Google Scholar 

  • Yamashita A, Nishikawa S, Rancourt DE (2010) Identification of five developmental processes during chondrogenic differentiation of embryonic stem cells. PLoS One 5:e10998

    Article  PubMed  Google Scholar 

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Correspondence to Hong Wei Ouyang .

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© 2012 Springer Science+Business Media B.V.

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Jiang, Y.Z., Tong, T., Heng, B.C., Ouyang, H.W. (2012). Cartilage Injuries: Role of Implantation of Human Stem/Progenitor Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_33

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