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Vitamin B6: Beyond Coenzyme Functions

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Water Soluble Vitamins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 56))

Abstract

Endogenous reactive intermediates such as photoexcited states of tissue chromophores, reactive oxygen species (ROS), reactive carbonyl species (RCS), and transition metal ions are mediators of tissue damage involved in initiation and progression of human pathologies including tumorigenesis, atherosclerosis, diabetes, and neurodegenerative disease. A large body of evidence now suggests that B6 vitamers antagonize the harmful activity of endogenous reactive intermediates fulfilling a very different role than that established as a cofactor for numerous enzymes. In this chapter, the structural basis of vitamin B6 activity as a potent antioxidant, metal chelator, carbonyl scavenger, and photosensitizer is presented and the physiological relevance is discussed.

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Acknowledgements

Supported in part by National Institutes of Health Grants (CA 106677-01, SWEHSC pilot research grant [ES06694], and GI Cancer Pilot Grant [SPORE, CA95060]).

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA

    Georg T. Wondrak & Elaine L. Jacobson

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  1. Georg T. Wondrak
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  2. Elaine L. Jacobson
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Correspondence to Georg T. Wondrak .

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Editors and Affiliations

  1. Imperial College of Science, Technology and Medicine, Royal Brompton & Harefield NHS Foundatio, Sydney Street, London, SW3 6NP, United Kingdom

    Olaf Stanger

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Wondrak, G.T., Jacobson, E.L. (2012). Vitamin B6: Beyond Coenzyme Functions. In: Stanger, O. (eds) Water Soluble Vitamins. Subcellular Biochemistry, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2199-9_15

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