Skip to main content
SpringerLink
Log in

Vanadium in Cancer Prevention

  • Chapter
  • First Online:
Vanadium

  • 1927 Accesses

Abstract

The pharmacological role of vanadium in health and disease remains one of the fascinating stories in biology. Recent studies have established vanadium as a novel regulator in assessing physiological and biochemical states of the animals. Vanadium exhibits biphasic effect, essentiality at low concentrations (0.05 μM) and toxicity at high doses (>10 μM). Vanadium inhibits growth of transformed cancer cells in culture. Various laboratories have confirmed the antitumorigenic potential of vanadium in liver, breast and colon cancer in vivo and various human cancer epithelial cell lines in vitro. Antiproliferative and induction of apoptosis may be the major mechanism of vanadium mediated inhibitions of cancer. Vanadium can play a central role in modulating phosphorylation states of various proteins in the cell and can affect many cellular processes regulated by cyclic AMP. In human vanadium is of interest pharmacologically but confirmation to its essentiality will require more significant information from experimental, clinical and epidemiological studies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1: 571–573

    Google Scholar 

  2. Mukherjee B, Patra B, Mahapatra S et al (2004) Vanadium-an element of atypical biological significance. Toxicol Lett 150:135–143

    CAS  Google Scholar 

  3. Almedeida M, Filipe S, Hunianes M et al (2001) Vanadium haloperoxidases from brown algae of the Laminariaceae family. Photochemistry 57:633–642

    Google Scholar 

  4. French RJ, Jones PJ (1993) Role of vanadium in nutrition: metabolism, essentiality and dietary consideration. Life Sci 52:339–346

    CAS  Google Scholar 

  5. Domingo JL (1996) Vanadium: a review of the reproductive and developmental toxicology. Reprod Toxicol 10:175–182

    CAS  Google Scholar 

  6. Anke M, Groppel B, Kosla T et al (1986) New research on vanadium deficiency in ruminants. In: Anke M et al (eds) Supplement-symposium: new trace elements. Friedrich-Schiller-Universitat, Jena, pp 1266–1275

    Google Scholar 

  7. Menon AS, Rau M, Ramasarma T et al (1980) Vanadate inhibit mevalonate synthesis and activates NADH oxidation in microsomes. FEBS Lett 114:139–141

    CAS  Google Scholar 

  8. Golden MH, Golden BE (1981) Trace elements. Potential importance in human nutrition with particular reference to zinc and vanadium. Br Med Bull 37:31–36

    CAS  Google Scholar 

  9. Barceloux DG (1999) Vanadium. J Toxicol Clin Toxicol 37:265–278

    CAS  Google Scholar 

  10. Byrne AR, Kosta L (1978) Vanadium in foods and in human body fluids and tissues. Sci Total Environ 10:17–30

    CAS  Google Scholar 

  11. Badmaev V, Prakash S, Majeed M (1999) A review of its potential role in the fight against diabetes. J Altern Complement Med 5:273–291

    CAS  Google Scholar 

  12. Mongold JJ, Cros GH, Vian L et al (1990) Toxicological aspects of vanadyl sulphate on diabetic rats: effects on vanadium levels and pancreatic B-cell morphology. Pharmacol Toxicol 67:192–198

    CAS  Google Scholar 

  13. Philips TD, Nechay BR, Heidelbaugh ND (1983) Vanadium: chemistry and the kidney. Fed Proc 42:2969–2973

    Google Scholar 

  14. Nechay BR (1984) Mechanisms of actions of vanadium. Annu Rev Pharmacol Toxicol 24:501–524

    CAS  Google Scholar 

  15. Orvig C, Thompson KH, Battell M et al (1995) Vanadium compounds as insulin mimics. Met Ions Biol Syst 31:575–594

    CAS  Google Scholar 

  16. Kieler J, Gromek A, Nissen N (1965) Studies on the antineoplastic effect of vanadium salts. Acta Chir Scand Suppl 343:154–164

    CAS  Google Scholar 

  17. Thompson HJ, Chasten ND, Meeker LD (1984) Dietary vanadyl (IV) sulphate inhibits chemically-induced mammary carcinogenesis. Carcinogenesis 5:849–851

    CAS  Google Scholar 

  18. Bishayee A, Chatterjee M (1995) Inhibition of altered liver cell foci and persistent nodule growth by vanadium during diethylnitrosamine-induced hepatocarcinogenesis in rats. Anticancer Res 15:455–462

    CAS  Google Scholar 

  19. Harding MM, Mokdsi G (2000) Antitumor metallocenes: structure-activity studies and interactions with biomolecules. Curr Med Chem 7:1289–1303

    CAS  Google Scholar 

  20. Murthy MS, Rao LN, Kuo LY et al (2000) Antitumor and toxicologic properties of the organometallic anti-cancer agent vanadocene dichloride. Inorg Chem Acta 152:117–124

    Google Scholar 

  21. WHO (1988) Vanadium. Environmental Health Criteria No. 80. Geneva

    Google Scholar 

  22. Baroch EF (1983) Vanadium and vanadium alloys. In: Seidel A (ed) Encyclopedia of chemical technology, vol 23. Wiley, New York, pp 673–687

    Google Scholar 

  23. Rosenbaum JB (1983) Vanadium compounds. In: Seidel A (ed) Encyclopedia of chemical technology, vol 23. Wiley, New York, pp 688–704

    Google Scholar 

  24. Al-Swaidan HM (1993) Determination of vanadium and nickelin oil products from Saudi Arabia by inductively coupled plasma mass spectrometry (ICP/MS). Anal Lett 26:141–146

    CAS  Google Scholar 

  25. Crans DC (1998) Chemistry of relevance to vanadium in the environment. In: Nriagu JO (ed) Vanadium in the environment. Part 1: chemistry and biochemistry. Wiley, New York, pp 73–96

    Google Scholar 

  26. Dafnis E, Sabatini S (1994) Biochemistry and pathophysiology of vanadium. Nephron 67:133–143

    CAS  Google Scholar 

  27. Crans DC, Bunch RL, Theisen LA (1989) Interaction of race levels of vanadium (IV) and vanadium (V) in biological systems. J Am Chem Soc 111:7597–7607

    CAS  Google Scholar 

  28. Erdmann E, Werdan K, Krawietz W et al (1984) Vanadate and its significance in biochemistry and pharmacology. Biochem Pharmacol 33:945–950

    CAS  Google Scholar 

  29. Nechay BR, Nanninga LB, Nechay PSE et al (1986) Role of vanadium in biology. Fed Proc 45:123–132

    Google Scholar 

  30. Ueki H, Okuhama R, Gresser MJ et al (1988) Interaction of vanadate with uridine and adenosine monophosphate: formation of ADP and ATP analogues. J Am Chem Soc 110:5869–5874

    Google Scholar 

  31. Wenzel UO, Fouqueray B, Biswas P et al (1995) Activation of mesangial cells by the phosphatase inhibitor vanadate. J Clin Invest 95:1244–1252

    CAS  Google Scholar 

  32. Ding M, Gannett PM, Rojanasakul Y et al (1994) One-electron reduction of vanadate by ascorbate and related free radical generation at physiological pH. J Inorg Biochem 55: 101–112

    CAS  Google Scholar 

  33. Shi X, Wang P, Jiang H et al (1996) Vanadium (IV) causes 2′-deoxyguanosine hydroxylation and deoxyribonucleic acid damage via free radical reaction. Ann Clin Lab Sci 26:39–49

    CAS  Google Scholar 

  34. Imbert V, Peyron JF, Far F et al (1994) Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem J 297:163–173

    CAS  Google Scholar 

  35. Yamaguchi M, Oishi H, Araki S et al (1995) Respiratory burst and tyrosine phosphorylation by vanadate. Arch Biochem Biophys 323:382–386

    CAS  Google Scholar 

  36. Kalyani P, Vijaya S, Ramasarma T (1992) Characterisation of oxygen free radicals generated during vanadate-stimulated NADH oxidation. Mol Cell Biochem 111:33–40

    CAS  Google Scholar 

  37. Bencherif M, Lukas RJ (1992) Vanadate amplifies receptor-mediated accumulation of inositol tris-and tetrakis phosphatase activities. Neurosci Lett 134:157–160

    CAS  Google Scholar 

  38. Cantley LC Jr, Cantley LG, Josephson L (1978) A characterisation of vanadate interactions with the (Na, K)-ATPase. Mechanistic and regulatory implications. J Biol Chem 253: 7361–7368

    CAS  Google Scholar 

  39. Cantley LC, Aisen P Jr (1979) The fate of cytoplasmatic vanadium implication on (Na, K)-ATPase inhibition. J Biol Chem 254:1781–1784

    CAS  Google Scholar 

  40. Brichard SM, Henquin JC (1995) The role of vanadium in the management of diabetes. Trends Pharmacol Sci 16:265–270

    CAS  Google Scholar 

  41. Macara IG (1986) Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol. J Biol Chem 261:9321–9327

    CAS  Google Scholar 

  42. Stern A, Yin X, Tsang S-S et al (1993) Vanadium as a modulator of cellular regulatory cascades and oncogene expression. Biochem Cell Biol 71:103–112

    CAS  Google Scholar 

  43. Roden M, Liener K, Fűrnsinn C et al (1993) Non-insulin like action of sodium orthovanadate in the isolated perfused liver of fed non-diabetic rats. Diabetologia 36:602–607

    CAS  Google Scholar 

  44. Tertrin-Clary C, DeLaLlosa-Hermier MP, Roy M et al (1992) Activation of phospholipase C by different effectors in rat placement cells. Cell Signal 4:727–732

    CAS  Google Scholar 

  45. Zick Y, Sagi-Eisenberg R (1990) A combination of hydrogen peroxide and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines. Biochemistry 29:10240–10245

    CAS  Google Scholar 

  46. Richelmi P, Mirabelli F, Salis A et al (1989) On the role of mitochondria in cell injury caused by vanadate-induced Ca2+ overload. Toxicology 57:29–44

    CAS  Google Scholar 

  47. Schmitz W, Scholz H, Erdmann E et al (1982) Effect of vanadium in the +5, +4 and +3 oxidation states on cardiac force of contraction, adenylatecyclase and (Na+ + K+)-ATPase activity. Biochem Pharmacol 31:3853–3860

    CAS  Google Scholar 

  48. Madsen KL, Porter VM, Fedorak RN (1994) Vanadium reduces sodium-dependent glucose transport and increases glycolytic activity in LLC-PK1 epithelia. J Cell Physiol 158:459–466

    CAS  Google Scholar 

  49. Pilkis SJ, El-Maghrabi MR (1988) Hormonal regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Biochem 57:755–783

    CAS  Google Scholar 

  50. Cupo MA, Donaldson WE (1987) Chromium and vanadium effects on glucose metabolism and lipid synthesis in the chick. Poult Sci 66(1):120–126

    CAS  Google Scholar 

  51. Sera M, Tanaka K, Morita T et al (1990) Increasing effect of vanadate on lipoprotein lipase activity in isolated rat fat pads. Arch Biochem Biophys 279(2):291–297

    CAS  Google Scholar 

  52. Coulombe RA Jr, Briskin DP, Keller RJ et al (1987) Vanadium dependent oxidation of pyridine nucleotide in rat liver microsomal membranes. Arch Biochem Biophys 255(2): 267–273

    CAS  Google Scholar 

  53. Hajjar JJ, Fucci JC, Rowe WA et al (1987) Effect of vanadate on amino acid transport in rat jejunam. Proc Soc Exp Biol Med 184:403–409

    CAS  Google Scholar 

  54. Leonard A, Gerber GB (1994) Mutagenecity, carcinogenecity and teratogenicity of vanadium compounds. Mutat Res 317:81–88

    CAS  Google Scholar 

  55. Kopf-Maier P, Wagner W, Hesse B et al (1981) Tumor inhibition by metallocenes: activity against leukemias and detection of the systemic effect. Eur J Cancer 17:665–669

    CAS  Google Scholar 

  56. Kopf-Maier P, Krahl D (1983) Tumor inhibition by metallocenes: ultrastructural localisation of titanium and vanadium, in treated tumor cells by electron energy loss spectroscopy. Chem Biol Interact 44:317–328

    CAS  Google Scholar 

  57. Kopf-Maier P (1982) Development of necroses virus, activation and giant cell formation after treatment of Ehrlich ascites tumor with metallocene dichloride. J Cancer Res Clin Oncol 103:145–164

    CAS  Google Scholar 

  58. Kopf-Maier P, Wagner W, Liss E (1981) Cytokinetic behaviour of Ehrlich ascites tumor after in vivo treatment with cis-diamminedichloroplatinum (II) and metallocene dichloride. J Cancer Res Clin Oncol 201:21–30

    Google Scholar 

  59. El-Naggar MM, El-Waseef AM, El-Halafawy KM et al (1998) Antitumor activities of vanadium (IV), manganese(IV), iron(III), cobalt(II) and copper(II) complexes of 2-methylaminopyridine. Cancer Lett 133:71–76

    CAS  Google Scholar 

  60. Scrivens PJ, Alaoui MA, Giannini G et al (2003) Cdc-25A inhibitory properties and antineoplastic activity of bisperoxovanadium analogues. Mol Cancer Ther 2:1053–1059

    CAS  Google Scholar 

  61. D’Cruz OJ, Uckun FM (2002) Metavan: a novel oxovanadium (IV) complex with broad spectrum anticancer activity. Expert Opin Investig Drugs 11:1829–1836

    Google Scholar 

  62. Navara CS, Benyumov A, Vassilev A et al (2001) Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells. Anticancer Drugs 12(4):369–376

    CAS  Google Scholar 

  63. Bishayee A, Oinam S, Basu M et al (2000) Vanadium chemoprevention of 7, 12-dimethylbenz(a) anthracene-induced rat mammary carcinogenesis: probable involvement of representative hepatic phase I and II xenobiotic metabolizing enzymes. Breast Cancer Res Treat 63(2):133–145

    CAS  Google Scholar 

  64. Moore CJ, Tricomi WA, Gould MN (1986) Interspecies comparison of polycyclic aromatic hydrocarbon metabolism in human and rat mammary epithelial cells. Cancer Res 46:4946–4952

    CAS  Google Scholar 

  65. Ray RS, Roy S, Ghosh S et al (2001) Suppression of cell proliferation, DNA protein cross-links, and induction of apoptosis by vanadium in chemical rat mammary carcinogenesis. Anticancer Drugs 12(4):369–376

    Google Scholar 

  66. Ray RS, Roy S, Samanta S et al (2005) Protective role of vanadium on the early process of rat mammary carcinogenesis by influencing expression of metallothionein. GGT-positive foci and DNA fragmentation. Cell Biochem Funct 23(6):447–456

    CAS  Google Scholar 

  67. Ray RS, Basu M, Ghosh B et al (2005) Vanadium, a versatile biochemical effector in chemical rat mammary carcinogenesis. Nutr Cancer 51(2):184–196

    CAS  Google Scholar 

  68. Ray RS, Rana B, Swami B et al (2006) Vanadium mediated apoptosis and cell cycle arrest in MCF7 cell line. Chem Biol Interact 63(3):239–247

    Google Scholar 

  69. Ray RS, Ghosh B, Rana A et al (2006) Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: chemopreventive activity of vanadium in vivo and in vitro. Int J Cancer 120(1):13–23

    Google Scholar 

  70. Bishayee A, Chatterjee M (1993) Selective enhancement of glutathione S-transferase activity in liver and extrahepatic tissues of rat following oral administration of vanadate. Acta Physiol Pharmacol Bulg 19(3):83–89

    CAS  Google Scholar 

  71. Posner BI, Faure R, Burgess JW et al (1994) Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem 269(6):4596–4604

    CAS  Google Scholar 

  72. Bishayee A, Chatterjee M (1995) Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. Br J Cancer 71(6): 1214–1220

    CAS  Google Scholar 

  73. Bishayee A, Karmakar R, Mandal A et al (1997) Vanadium-mediated chemoprotection against chemical hepatocarcinogenesis in rats: haematological and histological characteristics. Eur J Cancer Prev 6(1):58–70

    CAS  Google Scholar 

  74. Bishayee A, Roy S, Chatterjee M (1999) Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis. Oncol Res 11(1):41–53

    CAS  Google Scholar 

  75. Chakraborty A, Selvaraj S (2000) Differential modulation of xenobiotic metabolizing enzymes by vanadium during diethylnitrosamine-induced hepatocarcinogenesis in Sprague-Dawley rats. Neoplasma 47(2):81–89

    CAS  Google Scholar 

  76. Basak R, Saha BK, Chatterjee M (2000) Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3). Biochim Biophys Acta 1502(2):273–282

    CAS  Google Scholar 

  77. Basak R, Chatterjee M (2000) Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis. Life Sci 68(2):217–231

    CAS  Google Scholar 

  78. Basak R, Basu M, Chatterjee M (2000) Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3) inhibit diethylnitrosamine-induced rat liver carcinogenesis. Chem Biol Interact 128(1):1–18

    CAS  Google Scholar 

  79. Bukietyńska K, Podsiadly H, Karwecka Z (2003) Complexes of vanadium(III) with L-alanine and L-aspartic acid. J Inorg Biochem 94(4):317–325

    Google Scholar 

  80. Osińska-Królicka I, Podsiadły H, Bukietyńska K et al (2004) Vanadium(III) complexes with L-cysteine-stability, speciation and the effect on actin in hepatoma Morris 5123 cells. J Inorg Biochem 98(12):2087–2098

    Google Scholar 

  81. Chakraborty T, Ghosh S, Datta S et al (2003) Vanadium suppresses sister-chromatid exchange and DNA-protein crosslink formation and restores antioxidant status and hepatocellular architecture during 2-acetylaminofluorene-induced experimental rat hepatocarcinogenesis. J Exp Ther Oncol 3(6):346–362

    CAS  Google Scholar 

  82. Chattopadhyay MB, Mahendrakumar CB, Kanna PS et al (2004) Combined supplementation of vanadium and beta-carotene suppresses placental glutathione S-transferase-positive foci and enhances antioxidant functions during the inhibition of diethylnitrosamine-induced rat liver carcinogenesis. J Gastroenterol Hepatol 19(6):683–693

    CAS  Google Scholar 

  83. Chakraborty T, Chatterjee A, Saralaya MG et al (2006) Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. Life Sci 78(24):2839–2851

    CAS  Google Scholar 

  84. Chakraborty T, Chatterjee A, Saralaya MG et al (2006) Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression. J Biol Inorg Chem 11(7):855–866

    CAS  Google Scholar 

  85. Chakraborty T, Chatterjee A, Dhachinamoorthi D et al (2006) Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. Environ Mol Mutagen 47(8):603–615

    CAS  Google Scholar 

  86. Chakraborty T, Pandey N, Chatterjee A et al (2006) Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats. Mutat Res 609(2):117–128

    CAS  Google Scholar 

  87. Chakraborty T, Chatterjee A, Rana A et al (2007) Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. Biochim Biophys Acta 1772(1):48–59

    CAS  Google Scholar 

  88. Chakraborty T, Swamy AH, Chatterjee A et al (2007) Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats. J Cell Biochem 101(1):244–258

    CAS  Google Scholar 

  89. Chakraborty T, Chatterjee A, Rana A et al (2007) Suppression of early stages of neoplastic transformation in a two-stage chemical hepatocarcinogenesis model: supplementation of vanadium, a dietary micronutrient, limits cell proliferation and inhibits the formations of 8-hydroxy-2′-deoxyguanosines and DNA strand-breaks in the liver of sprague-dawley rats. Nutr Cancer 59(2):228–247

    CAS  Google Scholar 

  90. Kordowiak AM, Klein A, Goc A et al (2007) Comparison of the effect of VOSO4, Na3VO4 and NaVO3 on proliferation, viability and morphology of H35-19 rat hepatoma cell line. Pol J Pathol 58(1):51–57

    CAS  Google Scholar 

  91. Greenle RT, Murry T, Wingo PA (2000) Cancer statistics, 2000. CA Cancer J Clin 50:7–33

    Google Scholar 

  92. Kingsnorth AN, LaMuraglia GM, Ross JS et al (1986) Vanadate supplements and 1, 2-dimethylhydrazine induced colon cancer in mice: increased thymidine incorporation without enhanced carcinogenesis. Br J Cancer 53(5):683–686

    CAS  Google Scholar 

  93. Kanna PS, Mahendrakumar CB, Chakraborty T et al (2003) Effect of vanadium on colonic aberrant crypt foci induced in rats by 1, 2 dimethyl hydrazine. World J Gastroenterol 9(5):1020–1027

    CAS  Google Scholar 

  94. Kanna PS, Mahendrakumar CB, Chatterjee M et al (2003) Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis. J Biochem Mol Toxicol 17(6):357–365

    CAS  Google Scholar 

  95. Kanna PS, Mahendrakumar CB, Indira BN et al (2004) Chemopreventive effects of vanadium toward 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon. Environ Mol Mutagen 44(2):113–118

    CAS  Google Scholar 

  96. Kanna PS, Saralaya MG, Samanta K et al (2005) Vanadium inhibits DNA-protein cross-links and ameliorates surface level changes of aberrant crypt foci during 1,2-dimethylhydrazine induced rat colon carcinogenesis. Cell Biol Toxicol 21(1):41–52

    Google Scholar 

  97. Tan EY, Richard CL, Zhang H et al (2006) Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway. Am J Physiol Cell Physiol 291(3):C433–C444

    CAS  Google Scholar 

  98. Etcheverry SB, Ferrer EG, Naso L et al (2008) Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention. J Biol Inorg Chem 13(3):435–447

    CAS  Google Scholar 

  99. Samanta S, Swamy V, Suresh D et al (2008) Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction. Mutat Res 650(2):123–131

    CAS  Google Scholar 

  100. Samanta S, Chatterjee M, Ghosh B et al (2008) Vanadium and 1, 25 (OH)2 vitamin D3 combination in inhibitions of 1,2, dimethylhydrazine-induced rat colon carcinogenesis. Biochim Biophys Acta 1780(10):1106–1114

    CAS  Google Scholar 

  101. Holko P, Ligeza J, Kisielewska J et al (2008) The effect of vanadyl sulphate (VOSO4) on autocrine growth of human epithelial cancer cell lines. Pol J Pathol 59(1):3–8

    CAS  Google Scholar 

  102. Klein A, Holko P, Ligeza J et al (2008) Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol (Krakow) 56(3–4):115–121

    CAS  Google Scholar 

  103. Papaioannou A, Manos M, Karkabounas S et al (2004) Solid state and solution studies of a vanadium(III)-L-cysteine compound and demonstration of its antimetastatic, antioxidant and inhibition of neutral endopeptidase activities. J Inorg Biochem 98(6):959–968

    CAS  Google Scholar 

  104. Hierowski MT, Liebow C, Schally AV et al (1985) Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. FEBS Lett 179(2):252–256

    CAS  Google Scholar 

  105. Cortizo MS, Alessandrini JL, Etcheverry SB et al (2001) A vanadium/aspirin complex controlled release using a poly(beta-propiolactone) film. Effects on osteosarcoma cells. J Biomater Sci Polym Ed 12(9):945–959

    CAS  Google Scholar 

  106. Cortizo AM, Bruzzone L, Molinuevo S et al (2000) A possible role of oxidative stress in the vanadium-induced cytotoxicity in the MC3T3E1 osteoblast and UMR106 osteosarcoma cell lines. Toxicology 147(2):89–99

    CAS  Google Scholar 

  107. Molinuevo MS, Cortizo AM, Etcheverry SB (2008) Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells. Cancer Chemother Pharmacol 61(5):767–773

    CAS  Google Scholar 

  108. Fallico R, Ferrante M, Fiore M et al (1998) Epidemiological research into the consequences of vanadium assimilated through diet and of its effects on human health following research carried out on people from the Etna massif. J Prev Med Hyg 39:74–79

    Google Scholar 

  109. Lener J, Kučera J, Kodl M et al (1998) Health effects of environmental exposure to vanadium. In: Nriagu JO (ed) Vanadium in the environment. Part 2: health effects. Wiley, New York

    Google Scholar 

  110. Greenwald P, Milner JA, Anderson DE et al (2002) Micronutrients in cancer chemoprevention. Cancer Metastasis Rev 21:217–230

    CAS  Google Scholar 

  111. Evangelou AM (2002) Vanadium in cancer treatment. Crit Rev Oncol Hematol 42:249–265

    Google Scholar 

  112. Bishayee A, Banik S, Marimuthu P et al (1997) Vanadium-mediated suppression of diethylnitrosamine-induced chromosomal aberrations in rat hepatocytes and its correlation with induction of hepatic glutathione and glutathione-S-transferase. Int J Oncol 102:413–423

    Google Scholar 

  113. Crans DC, Rithner CD, Theisen LA (1990) Application of time-resolved vanadium-51 2D NMR for quantitation of kinetic exchange pathways between vanadate monomer, dimer, tetramer, and pentamer. J Am Chem Soc 112:2901–2908

    CAS  Google Scholar 

  114. Heath E, Howarth OW (1981) Vanadium-51 and oxygen-17 nuclear magnetic resonance study of vanadate(V) equilibria and kinetics. J Chem Soc Dalton 1981:1105–1110

    Google Scholar 

  115. Hamilton EE, Wilker JJ (2004) Inorganic oxo compounds reacts with alkaline agents: implication for DNA damage. Angew Chem Int Ed Engl 43(25):3290–3292

    CAS  Google Scholar 

  116. Kawabe K, YoshikawaY AY et al (2006) Possible mode of action for insulin mimetic activity of vanadyl (IV) compounds in adipocytes. Life Sci 78:2860–2866

    CAS  Google Scholar 

  117. Zhang Z, Leonard SS, Huang C et al (2003) Role of oxygen species and MAPKs in vanadate- induced G2/M phase arrest. Free Radic Biol Med 34:1333–1342

    CAS  Google Scholar 

  118. Molinuevo MS, Barrio DA, Cortizo AM et al (2004) Antitumoral properties of two newvanadyl(IV) complexes in culture: role of apoptosis and oxidative stress. Cancer Chemother Pharmacol 53:163–172

    CAS  Google Scholar 

  119. Fawcett JP, Farquhar SJ, Thou T et al (1997) Oral vanadyl sulphate does not affect blood cells, viscosity or biochemistry in humans. Pharmacol Toxicol 80:202–206

    CAS  Google Scholar 

  120. Goldfine AB, Simonson DC, Folli F et al (1995) Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 80:3311–3320

    CAS  Google Scholar 

  121. Somerville J, Davies B (1962) Effect of vanadium on serum cholesterol. Am Heart J 64:54–56

    CAS  Google Scholar 

  122. Dimond EG, Caravace J, Benchimol A (1963) Vanadium, excretion, toxicity, lipid effect in man. Am J Clin Nutr 12:49–53

    CAS  Google Scholar 

  123. Schroeder HA, Balassa JJ, Tipton IH (1963) Abnormal trace metals in man- Vanadium. J Chronic Dis 16:1047–1071

    CAS  Google Scholar 

  124. Nemery B (1990) Metal toxicity and the respiratory tract. Eur Respir J 3(2):202–219

    CAS  Google Scholar 

  125. Ehrlich VA, Nersesyan AK, Atefie K et al (2008) Inhalative exposure to vanadium pentoxide causes DNA damage in workers: results of a multiple end point study. Environ Health Perspect 116(12):1689–1693

    CAS  Google Scholar 

  126. Maines MD (1994) Modulating factors that determine interindividual differences in response to metals. In: Mertz W et al (eds) Risk assessment of essential elements. ILSI Press, Washington, DC, pp 21–39

    Google Scholar 

Download references

Acknowledgement

We thank Subrata Pramanik (M. Pharm.), Rohullah Roien (M. Pharm.) and Dr. Kaushik Roy for their continuous help and support for the preparation of the manuscript.

Author information

Authors and Affiliations

  1. Chemical Carcinogenesis and Chemoprevention Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, West Bengal, India

    Subhadeep Das, Mary Chatterjee, Muthumani Janarthan & Malay Chatterjee

  2. Department of Surgery, Columbia University, 17-401, 630W, 168th street, New York, 10032, USA

    Hari Ramachandran

Authors
  1. Subhadeep Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mary Chatterjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Muthumani Janarthan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hari Ramachandran
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Malay Chatterjee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Malay Chatterjee .

Editor information

Editors and Affiliations

  1. , Biological Sciences, Hiroshima University, Kagamiyama 1-3-1, Hiroshima, 739-8526, Japan

    Hitoshi Michibata

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Das, S., Chatterjee, M., Janarthan, M., Ramachandran, H., Chatterjee, M. (2012). Vanadium in Cancer Prevention. In: Michibata, H. (eds) Vanadium. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0913-3_8

Download citation

Publish with us

Policies and ethics

Search

Navigation