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TRP Channels in Vascular Endothelial Cells

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Endothelial cells regulate multiple vascular functions, such as vascular tone, permeability, remodeling, and angiogenesis. It is known for long that cytosolic Ca2+ level ([Ca2+]i) and membrane potential of endothelial cells are crucial factors to initiate the signal transduction cascades, leading to diverse vascular functions. Among the various kinds of endothelial ion channels that regulate ion homeostasis, transient receptor potential (TRP) channels emerge as the prime mediators for a diverse range of vascular signaling. The characteristics of TRP channels, including subunit heteromultimerization, diverse ion selectivity, and multiple modes of activation, permit their versatile functional roles in vasculatures. Substantial amount of evidence demonstrates that many TRP channels in endothelial cells participate in physiological and pathophysiological processes of vascular system. In this article, we summarize the recent findings of TRP research in endothelial cells, aiming at providing up-to-date information to the researchers in this rapidly growing field.

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Acknowledgments

We thank the support from Hong Kong RGC Grants (CUHK477307, CUHK477408 and CUHK479109), Focused Investment Scheme of CUHK and Li Ka Shing Institute of Health Sciences.

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  1. Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China

    Ching-On Wong & Xiaoqiang Yao

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Correspondence to Ching-On Wong .

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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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© 2011 Springer Science+Business Media B.V.

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Wong, CO., Yao, X. (2011). TRP Channels in Vascular Endothelial Cells. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_40

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