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TRP Channels and Neural Persistent Activity

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

One of the integrative properties of the nervous system is its capability to, by transient motor commands or brief sensory stimuli, evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing. This neural activity, named persistent activity, is found in a good number of brain regions and is thought to be a neural substrate for short-term storage and accumulation of sensory or motor information [1]. Examples of this persistent neural activity have been reported in prefrontal [2] and entorhinal [3] cortices, as part of the neural mechanisms involved in short-term working memory [4]. Interestingly, the general organization of the motor systems assumes the presence of bursts of short-lasting motor commands encoding movement characteristics such as velocity, duration, and amplitude, followed by a maintained tonic firing encoding the position at which the moving appendage should be maintained [5, 6]. Generation of qualitatively similar sustained discharges have also been found in spinal and supraspinal regions in relation to pain processing [7, 8]. Thus, persistent neural activity seems to be necessary for both behavioral (positions of fixation) and cognitive (working memory) processes. Persistent firing mechanisms have been proposed to involve the participation of a non-specific cationic current (CAN current) mainly mediated by activation of TRPC channels. Because the function and generation of persistent activity is still poorly understood, here we aimed to review and discuss the putative role of TRP-like channels on its generation and/or maintenance.

An erratum to this chapter can be found athttp://dx.doi.org/10.1007/978-94-007-0265-3_53

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Acknowledgments

This work was supported by Fundación Eugenio Rodriguez Pascual. L.J-D was supported by Juan de la Cierva MICINN Programme, J.D.N-L by Ramón y Cajal MICINN Programme and A.R. was supported by a CONSOLIDER-INGENIO grant The Spanish Ion Channel Initiative (SICI) (MICINN, CSD2008-00005).

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Authors and Affiliations

  1. Section of Physiology, Department of Functional Biology and Health Sciences, School of Biology, University of Vigo, Campus Lagoas-Marcosende, 36310, Vigo (Pontevedra), Spain

    Antonio Reboreda

  2. Instituto Neurociencias F. Oloriz, Universidad de Granada, 18071, Granada, Spain

    Lydia Jiménez-Díaz & Juan D. Navarro-López

  3. Department of Physiology, School of Medicine, Universidad de Granada, 18071, Granada, Spain

    Lydia Jiménez-Díaz & Juan D. Navarro-López

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  1. Antonio Reboreda
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  2. Lydia Jiménez-Díaz
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  3. Juan D. Navarro-López
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Correspondence to Antonio Reboreda .

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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Reboreda, A., Jiménez-Díaz, L., Navarro-López, J.D. (2011). TRP Channels and Neural Persistent Activity. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_32

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