Abstract
Disposable Wave bioreactors are presently used world-wide in many cell culture laboratories. In its simple operating mode, cells are cultivated in Wave reactors with limited at-line control of pH or DO. For process development purposes, and especially for high cell density cultivations, reliable in-line or on-line pH and DO monitoring and control systems are needed. In the present study, pH and DO in a Wave bioreactor was monitored and controlled using a standard control system for stirred tank bioreactors. Furthermore, measurements were performed with standard pH and DO sensors in an external loop with cell free supernatant.
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Aizawa, P., Benemar, C., Wingenblixt, C., Martinelle, K., Lindner, E. (2010). Conventional Stirred Bioreactor Control System for Monitoring and Controlling pH and DO in a Wave Bioreactor. In: Noll, T. (eds) Cells and Culture. ESACT Proceedings, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3419-9_144
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DOI: https://doi.org/10.1007/978-90-481-3419-9_144
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Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-3418-2
Online ISBN: 978-90-481-3419-9
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