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β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice]

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The Islets of Langerhans

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 654))

Abstract

This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia. ob/ob Mice have large pancreatic islets. The β-cells respond adequately to most stimuli, and ob/ob mice have been used as a rich source of pancreatic islets with high insulin release capacity. ob/ob Mice can perhaps be described as a model for the prediabetic state. The large capacity for islet growth and insulin release makes ob/ob mice a good model for studies on how β-cells can cope with prolonged functional stress.

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  1. Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umeå University, S-901 87, Umeå, Sweden

    Per Lindström

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    Md. Shahidul Islam

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Lindström, P. (2010). β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice]. In: Islam, M. (eds) The Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 654. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3271-3_20

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