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Cyclic AMP Signaling in Pancreatic Islets

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The Islets of Langerhans

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 654))

Abstract

Cyclic 3’5’AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

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  1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4ONR, Scotland

    Brian Furman

  2. University of Nottingham Malaysia Campus, Jalan Broga, 43500, Semenyih, Selangor Darul Ehsan, Malaysia

    Wee Kiat Ong

  3. Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Taylor Street, Glasgow, G4ONR, UK

    Nigel J. Pyne

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    Md. Shahidul Islam

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Furman, B., Ong, W.K., Pyne, N.J. (2010). Cyclic AMP Signaling in Pancreatic Islets. In: Islam, M. (eds) The Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 654. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3271-3_13

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