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The Use of Magnetic Resonance Imaging to Select Patients for Multiple Sclerosis Clinical Trials

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Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis

Part of the book series: Topics in Neuroscience ((TOPNEURO))

Abstract

The standard and most common approaches used in the selection of patients for multiple sclerosis (MS) treatment trials have been based primarily on clinical criteria. Entrance and selection criteria typically include disease classification (e.g. relapsing versus secondary progressive MS), an inclusive range of disability scores, the pre-trial exacerbation rate, and age. Today we are at an important junction in trials design, such that magnetic resonance imaging (MRI)-based criteria are recognized as increasingly important additional selection criteria in MS clinical trials.

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    J. H. Simon

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  1. J. H. Simon
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Editors and Affiliations

  1. Neuroimaging Research Unit, Department of Neuroscience Scientific Institute Ospedale San Raffaele, University of Milan, Italy

    Massimo Filippi

  2. Department of Radiology, University of Pennsylvania, Philadelphia, USA

    Robert I. Grossman

  3. Clinical Trials Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy

    Giancarlo Comi

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© 1999 Springer-Verlag Italia

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Simon, J.H. (1999). The Use of Magnetic Resonance Imaging to Select Patients for Multiple Sclerosis Clinical Trials. In: Filippi, M., Grossman, R.I., Comi, G. (eds) Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2153-2_3

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  • DOI: https://doi.org/10.1007/978-88-470-2153-2_3

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2180-8

  • Online ISBN: 978-88-470-2153-2

  • eBook Packages: Springer Book Archive

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