Abstract
Hemoglobin (Hb) is a prototype of macromolecules whose functional properties are controlled by ionic effectors and a paradigm for study of the structure, function and allosteric interactions of proteins. By virtue of its well-defined roles in transporting O2 from the respiratory surfaces to the tissues and metabolic end-products such as CO2, protons, heat in the opposite direction, and its implication in regulating other processes in red cells, it forms an ideal model for probing the mechanisms of molecular adaptations to environmental conditions and physiological demands [[16], [62]].
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Weber, R.E. (2000). Adaptations for Oxygen Transport: Lessons from Fish Hemoglobins. In: Hemoglobin Function in Vertebrates. Springer, Milano. https://doi.org/10.1007/978-88-470-2111-2_2
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DOI: https://doi.org/10.1007/978-88-470-2111-2_2
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