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Glucose Metabolism

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Cachexia and Wasting: A Modern Approach

Abstract

In 1919, glucose intolerance became the earliest recognised metabolic abnormality in cancer patients. Prior to the development of severe malnutrition, patients with colon, gastric, sarcoma, endometrial, prostate, localised head, neck and lung cancer had many of the metabolic abnormalities of type II (non-insulin-dependent) diabetes mellitus. These metabolic abnormalities included glucose intolerance, an increase in both hepatic glucose production (HGP) and glucose recycling, and insulin resistance. In a study of over 600 cancer patients, a diabetic pattern of glucose tolerance test was noted in over one-third of the patients [1].

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Author information

Authors and Affiliations

  1. Obstetrics and Ginecology Unit, Sirai Hospital, Carbonia, Italy

    Antonio Macciò

  2. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Clelia Madeddu & Giovanni Mantovani

Authors
  1. Antonio Macciò
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  2. Clelia Madeddu
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  3. Giovanni Mantovani
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Editor information

Editors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Giovanni Mantovani

  2. Department of Clinical Cardiology, Imperial College, NHLI, London, UK

    Stefan D. Anker

  3. Department of Cardiology Charité, Applied Cachexia Research, Campus Virchow-Klinikum, Berlin, Germany

    Stefan D. Anker

  4. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akio Inui

  5. GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St. Louis, MO, USA

    John E. Morley

  6. Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy

    Filippo Rossi Fanelli

  7. Department of Infectious Diseases, IRCCS S.Matteo Polyclinic, University of Pavia, Pavia, Italy

    Daniele Scevola

  8. Bone Marrow and Blood Stem Cell Transplantation Program, Center for Lymphoma and Myeloma, New York Presbyterian Hospital/Weill Medical Center, New York, NY, USA

    Michael W. Schuster

  9. Department of Medicine-Geriatrics, University of New York at Stony Brook VAMC, Northport, NY, USA

    Shing-Shing Yeh

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© 2006 Springer-Verlag Italia

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Macciò, A., Madeddu, C., Mantovani, G. (2006). Glucose Metabolism. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_20

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  • DOI: https://doi.org/10.1007/978-88-470-0552-5_20

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0471-9

  • Online ISBN: 978-88-470-0552-5

  • eBook Packages: MedicineMedicine (R0)

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