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Immunological Aspects of Moyamoya Disease

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Moyamoya Disease Update

Abstract

Immunological phenomena have pervasive effects on the human body. Many physiological and pathological processes involve the immune system. Because of this pervasiveness, it is often difficult to know whether an observed immunological reaction truly underlies a process or whether it is simply an epiphenomenon. The role of the immune system in moyamoya disease is a controversial issue. The etiology of moyamoya disease is currently unknown. Various etiologies, genetic and environmental, have been proposed; however, none have been definitively proven. There is a lot of evidence for immunological abnormalities in patients with moyamoya disease. However, much of the evidence is indirect and lacks a solid causal relationship. Nonetheless, it is strongly believed that immunological processes play an important role at least in the progression of moyamoya disease. In this chapter, the pathological and epidemiological evidence that supports the immunological origin of moyamoya disease is discussed.

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References

  1. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165–197

    Article  PubMed  CAS  Google Scholar 

  2. Ridker PM, Hennekens CH, Buring JE et al (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342(12):836–843

    Article  PubMed  CAS  Google Scholar 

  3. Andersson J, Johansson L, Ladenvall P et al (2009) C-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study. Cerebrovasc Dis 27(6):544–551

    Article  PubMed  CAS  Google Scholar 

  4. Mach F, Schonbeck U, Sukhova GK et al (1998) Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 394(6689):200–203

    Article  PubMed  CAS  Google Scholar 

  5. Saha P, Modarai B, Humphries J et al (2009) The monocyte/macrophage as a therapeutic target in atherosclerosis. Curr Opin Pharmacol 9(2):109–118

    Article  PubMed  CAS  Google Scholar 

  6. Takebayashi S, Matsuo K, Kaneko M (1984) Ultrastructural studies of cerebral arteries and collateral vessels in moyamoya disease. Stroke 15(4):728–732

    Article  PubMed  CAS  Google Scholar 

  7. Takekawa Y, Umezawa T, Ueno Y et al (2004) Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease. Neuropathology 24(3):236–242

    Article  PubMed  Google Scholar 

  8. Masuda J, Ogata J, Yutani C (1993) Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease. Stroke 24(12):1960–1967

    Article  PubMed  CAS  Google Scholar 

  9. Houkin K, Yoshimoto T, Abe H et al (1998) Role of basic fibroblast growth factor in the pathogenesis of moyamoya disease. Neurosurg Focus 5(5):e2

    Article  PubMed  CAS  Google Scholar 

  10. Soriano SG, Cowan DB, Proctor MR et al (2002) Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery 50(3):544–549

    PubMed  Google Scholar 

  11. Nanba R, Kuroda S, Ishikawa T et al (2004) Increased expression of hepatocyte growth factor in cerebrospinal fluid and intracranial artery in moyamoya disease. Stroke 35(12):2837–2842

    Article  PubMed  CAS  Google Scholar 

  12. Kim SK, Yoo JI, Cho BK et al (2003) Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease. Stroke 34(12):2835–2841

    Article  PubMed  CAS  Google Scholar 

  13. Sasaki T, Nogawa S, Amano T (2006) Co-morbidity of moyamoya disease with Graves' disease. report of three cases and a review of the literature. Intern Med 45(9):649–653

    Article  PubMed  Google Scholar 

  14. Im SH, Oh CW, Kwon OK et al (2005) Moyamoya disease associated with Graves disease: special considerations regarding clinical significance and management. J Neurosurg 102(6):1013–1017

    Article  PubMed  Google Scholar 

  15. Tendler BE, Shoukri K, Malchoff C et al (1997) Concurrence of Graves' disease and dysplastic cerebral blood vessels of the moyamoya variety. Thyroid 7(4):625–629

    Article  PubMed  CAS  Google Scholar 

  16. Utku U, Asil T, Celik Y et al (2004) Reversible MR angiographic findings in a patient with autoimmune Graves disease. Am J Neuroradiol 25(9):1541–1543

    PubMed  Google Scholar 

  17. Booth F, Yanofsky R, Ross IB et al (1999) Primary antiphospholipid syndrome with moyamoya-like vascular changes. Pediatr Neurosurg 31(1):45–48

    Article  PubMed  CAS  Google Scholar 

  18. Bakdash T, Cohen AR, Hempel JM, Hoagland J, Newman AJ (2002) Moyamoya, dystonia during hyperventilation, and antiphospholipid antibodies. Pediatr Neurol 26(2):157–160

    Article  PubMed  Google Scholar 

  19. Bonduel M, Hepner M, Sciuccati G et al (2001) Prothrombotic disorders in children with moyamoya syndrome. Stroke 32(8):1786–1792

    Article  PubMed  CAS  Google Scholar 

  20. Jea A, Smith ER, Robertson R et al (2005) Moyamoya syndrome associated with Down syndrome: outcome after surgical revascularization. Pediatrics 116(5):e694–701

    Article  PubMed  Google Scholar 

  21. Kusters MA, Verstegen RH, Gemen EF et al (2009) Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol 156(2):189–193

    Article  PubMed  CAS  Google Scholar 

  22. Goldacre MJ, Wotton CJ, Seagroatt V et al (2004) Cancers and immune related diseases associated with Down's syndrome: a record linkage study. Arch Dis Child 89(11):1014–1017

    Article  PubMed  CAS  Google Scholar 

  23. Leno C, Mateo I, Cid C et al (1998) Autoimmunity in Down's syndrome: another possible mechanism of moyamoya disease. Stroke 29(4):868–869

    Article  PubMed  CAS  Google Scholar 

  24. Yamada H, Deguchi K, Tanigawara T et al (1997) The relationship between moyamoya disease and bacterial infection. Clin Neurol Neurosurg 99(Suppl 2):S221–224

    PubMed  Google Scholar 

  25. Tanigawara T, Yamada H, Sakai N et al (1997) Studies on cytomegalovirus and Epstein-Barr virus infection in moyamoya disease. Clin Neurol Neurosurg 99(Suppl 2):S225–228

    PubMed  Google Scholar 

  26. Visudhiphan P, Chiemchanya S, Sirinavin S (1992) Internal carotid artery occlusion associated with Mycoplasma pneumoniae infection. Pediatr Neurol 8(3):237–239

    Article  PubMed  CAS  Google Scholar 

  27. Leonardi S, Pavone P, Rotolo N et al (2005) Stroke in two children with Mycoplasma pneumoniae infection. A causal or casual relationship? Pediatr Infect Dis J 24(9):843–845

    Article  PubMed  Google Scholar 

  28. Fu M, Wong KS, Lam WW et al (1998) Middle cerebral artery occlusion after recent Mycoplasma pneumoniae infection. J Neurol Sci 157(1):113–115

    Article  PubMed  CAS  Google Scholar 

  29. Tanir G, Aydemir C, Yilmaz D et al (2006) Internal carotid artery occlusion associated with Mycoplasma pneumoniae infection in a child. Turk J Pediatr 48(2):166–171

    PubMed  Google Scholar 

  30. Greco F, Castellano Chiodo D, Sorge A et al (2006) Multiple arterial ischemic strokes in a child with moyamoya disease and Mycoplasma pneumoniae infection. Minerva Pediatr 58(1):63–68

    PubMed  CAS  Google Scholar 

  31. Eleftheriou D, Dillon MJ, Brogan PA (2009) Advances in childhood vasculitis. Curr Opin Rheumatol 21(4):411–418

    Article  PubMed  Google Scholar 

  32. Pinna GS, Kafetzis DA, Tselkas OI et al (2008) Kawasaki disease: an overview. Curr Opin Infect Dis 21(3):263–270

    Article  PubMed  Google Scholar 

  33. Tann OR, Tulloh RM, Hamilton MC (2008) Takayasu's disease: a review. Cardiol Young 18(3):250–259

    Article  PubMed  Google Scholar 

  34. Togao O, Mihara F, Yoshiura T et al (2004) Prevalence of stenoocclusive lesions in the renal and abdominal arteries in moyamoya disease. Am J Roentgenol 183(1):119–122

    Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, Republic of Korea

    Ji Hoon Phi, Kyu-Chang Wang & Byung-Kyu Cho

  2. Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Research Center for Rare Disease, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, 110–744, Republic of Korea

    Seung-Ki Kim

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  1. Ji Hoon Phi
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Correspondence to Ji Hoon Phi .

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Editors and Affiliations

  1. Department of Neurosurgery, Seoul National University College of Medicine Seoul National University Children's Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea

    Byung-Kyu Cho (Professor) (Professor)

  2. Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8578, Japan

    Teiji Tominaga (Professor, Chairman) (Professor, Chairman)

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© 2010 Springer

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Phi, J.H., Kim, SK., Wang, KC., Cho, BK. (2010). Immunological Aspects of Moyamoya Disease. In: Cho, BK., Tominaga, T. (eds) Moyamoya Disease Update. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99703-0_13

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  • DOI: https://doi.org/10.1007/978-4-431-99703-0_13

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-99702-3

  • Online ISBN: 978-4-431-99703-0

  • eBook Packages: MedicineMedicine (R0)

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