Abstract
Many studies using monoclonal antibodies have demonstrated that fucosylated carbohydrate chains are involved in various physiological functions including development, neuronal activity, and cancerous transformation. The genes encoding fucosyltransferases which synthesize fucosylated carbohydrate antigens have been cloned, and their function has been gradually elucidated by analyses of their substrate specificities and biological functions (Taniguchi et al. 2002).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Homeister JW, Thall AD et al (2001) The α(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15:115–126
Kudo T, Kaneko M et al (2004) Normal embryonic and germ cell development in mice lacking α1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Mol Cell Biol 24:4221–4228
Narimatsu H, Iwasaki H et al (1998) Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 58:512–518
Nishihara S, Hiraga T et al (1999) Molecular behavior of mutant Lewis enzymes in vivo. Glycobiology 9:373–382
Taniguchi N, Honke K, Fukuda M (eds) (2002) Handbook of glycosyltransferases and related genes. Springer, Tokyo
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Kudo, T., Narimatsu, H. (2008). Fucosyltransferase (α1,2/ α1,3/ α1,4-fucosyltransferases). In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77922-3_9
Download citation
DOI: https://doi.org/10.1007/978-4-431-77922-3_9
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77921-6
Online ISBN: 978-4-431-77922-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)