Summary
During the course of stereotactic surgery for parkinson’s disease (PA) and other involuntary movement disorders, depth electrode recordings were made from components of the basal ganglia: putamen, external and internal segments of globus pallidus. These revealed that the spontaneous activity in the internal segment of globus pallidus (GPi) was very high, especially in rigid and akinetic type of PA.
In the posterior part of GPi, we observed unitary or multiunitary spike discharges related to the voluntary movement of the contralateral body part (extremity, mouth). In patients with choreic movement, irregular burst discharges were frequently found in GPI area.
Although still preliminary, depth recording from the human basal ganglia directly demonstrated that the behavior of GPi neurons in rigid and akinetic type of PA was similar to that found in experimental model of PA in monkeys. A hypothetical organization of human GPi is briefly discussed.
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Ohye, C. (1995). Activity of the Pallidal Neurons Related to Voluntary and Involuntary Movements in Humans. In: Kimura, M., Graybiel, A.M. (eds) Functions of the Cortico-Basal Ganglia Loop. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68547-0_12
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DOI: https://doi.org/10.1007/978-4-431-68547-0_12
Publisher Name: Springer, Tokyo
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