Abstract
Serotonin (5-hydroxytryptamine, 5-HT) has a significant, but certainly not exclusive, role in the core behaviors that are disturbed in affective disorders (e.g., mood, sleep, sexual activity, appetite, circadian and seasonal rhythms, neuroendocrine function, body temperature, motor activity, and cognitive function (Meltzer and Lowy 1987). There has been especially extensive interest in central 5-HT2 receptor dysfunction as an important factor in the etiology of affective disorders.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Affolter H, Erne P, Buergisser E, Pletscher A (1984) Ca2+ as messenger of 5-HT2- receptor stimulation in human blood platelets. Naunyn Schmiedebergs Arch Pharmacol 325: 337–342
Arora RC, Meltzer HY (1989a) Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatry 146: 730–736
Arora RC, Meltzer HY (1989b) Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients. Life Sci 44: 725–734
Biegon A, Weizman A, Karp L, Ram A, Tiano S, Wolff M (1987) Serotonin 5-HT2 receptor binding on blood platelets: a peripheral marker for depression Life Sci 41: 2485–2492
Biegon A, Grinspoon A, Blumenfeld B, Bleich A, Apter A, Mester R (1990) Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology 100: 165–167
Bothwell RA, Eccleston D, Marshall E (1994) Platelet intracellular calcium in patients with recurrent affective disorders. Psychopharmacology 114: 375–381
Brusov OS, Beliaev BS, Katasonov AB, Zlobina GP, Factor MI, Lideman RR (1989) Does platelet serotonin receptor supersensitivity accompany endogenous depression Biol Psychiatry 25: 375–381
Cheetham SC, Crompton MR, Katona CLE, Horton RW (1988) Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res 443: 272–280
Conn PJ, Sanders-Bush E (1986) Regulation of serotonin-stimulated phosphoinositide hydrolysis; relation to the serotonin 5-HT-2 binding site. J Neurosci 6: 3669–3675
Cook EH, Fletcher KE, Wainwright M, Marks N, Yan S-Y, Leventhal BL (1994) Primary structure of the human platelet serotonin 5-HT2A receptor: identity with frontal cortex serotonin 5-HT2A receptor. J Neurochem 63: 465–469
Cowen PJ, Charig EM, Fraser S, Elliott JM (1987) Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment. J Affect Disord 13: 45–50
Deakin JF, Pennell I, Upadhyaya AJ, Lofthouse R (1990) A neuroendocrine study of 5-HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology 101: 85–92
De Chaffoy de Courcelles D, Leysen JE, De Clerck F, Van Belle H, Janssen PAJ (1985) Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites. J Biol Chem 260: 7603–7608
Dubovsky SL, Christiano J, Daniell LC, Franks RD, Murphy J, Adler L, Baker N, Harris A (1989) Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 46: 632–638
Dubovsky SL, Lee C, Christiano J, Murphy J (1991) Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 29: 441–450
Eckert A, Riemann GD, Aldenhoff J, Mueller WE (1993) Elevated intracellular calcium levels after 5-HT2 receptor stimulation in platelets of depressed patients. Biol Psychiatry 34: 565–568
Kagaya A, Mikuni M, Kusumi I, Yamamoto H, Takahashi K (1990) Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C. J Pharmacol Exp Ther 255: 305–311
Koyama T, Meitzer HY (1986) A biochemical and neuroendocrine study of the serotonergic system in depression. In: Hippius H (ed) New results in depression research. Springer, Berlin Heidelberg, pp 169–188
Kusumi I, Mikuni M, Kuroda Y, Takahashi K (1990) Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices. J Neural Transm 80: 181–188
Kusumi I, Koyama T, Yamashita I (1991a) Effect of various factors on serotonin-induced Ca2+ response in human platelets. Life Sei 48: 2405–2412
Kusumi I, Koyama T, Yamashita I (1991b) Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients. Biol Psychiatry 30: 310–312
Kusumi I, Mikuni M, Takahashi K (1991c) Effect of subchronic antidepressant administration on serotonin-stimulated phosphoinositide hydrolysis in para- chlorophenylalanine-treated rat hippocampal slices. Prog Neuropsychopharmacol Biol Psychiatry 15: 393–403
Kusumi I, Koyama T, Yamashita I (1992) Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorder. Biol Psychiatry 32: 731–734
Kusumi I, Koyama T, Yamashita I (1994a) Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology 113: 322–327
Kusumi I, Koyama T, Yamashita I (1994b) Effect of mood stabilizing agents on agonist-induced calcium mobilization in human platelets. J Psychiatr Neurosci 19: 222–225
Maes M, Meitzer HY (1995) The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 933–944
Maes M, Vandervorst C, Suy E, Minner B, Raus J (1991) A multivariate study on the simultaneous urinary free Cortisol, plasma Cortisol, adrenocorticotropic hormone and beta-endorphin escape from suppression by dexamethasone in melancholic patients. Acta Psychiatr Scand 83: 480–491
Mann JJ, Stanley M, McBride PA, McEwen BS (1986) Increased serotonin2 and beta- adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 43: 954–959
Martin GR, Humphrey PPA (1994) Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology 33: 261–273
McKeith IG, Marshall EF, Ferrier IN, Armstrong MM, Kennedy WN, Perry RH, Perry EK, Eccleston D (1987) 5-HT receptor binding in post-mortem brain from patients with affective disorder. J Affect Disord 13: 67–74
Meitzer HY, Lowy MT (1987) The serotonin hypothesis of depression. In: Meitzer HY (ed) Psychopharmacology: the third generation of progress. Raven, New York, pp 513–526
Meitzer HY, Umberkoman-Wiita B, Robertson A, Tricou BJ, Lowy M, Perline R (1984) Effect of 5-hydroxytryptophan on serum Cortisol levels in major affective disorders; enhanced response in depression and mania. Arch Gen Psychiatry 41: 366–374
Mikuni M, Kusumi I, Kagaya A, Kuroda Y, Mori H, Takahashi K (1991) Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 15: 49–61
Mikuni M, Kagaya A, Takahashi K, Meitzer HY (1992) Serotonin but not norepinephrine-induced calcium mobilization of platelets is enhanced in affective disorders. Psychopharmacology 106: 311–314
Muraoka S, Mikuni M, Kagaya A, Saitoh K, Takahashi K (1993) Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells. Neuroendocrinology 57: 322–329
Nishizuka Y (1986) Studies and perspectives of protein kinase C. Science 233: 305–312
Okamoto Y, Kagaya A, Shinno H, Motohashi N, Yamawaki S (1994) Serotonin- induced platelet calcium mobilization is enhanced in mania. Life Sei 56: 327–332
Owen F, Chambers DR, Cooper SJ, Crow TJ, Johnson JA, Lofthouse R, Poulter M (1986) Serotonergic mechanisms in brains of suicide victims. Brain Res 362: 185–188
Pandey GN, Pandey SC, Janicak PG, Marks RC, Davis JM (1990) Platelet serotonin-2 receptor binding sites in depression and suicide. Biol Psychiatry 28: 215–222
Pletscher A (1988) Platelets as models: use and limitations. Experientia 44: 152–155
Sanders-Bush E, Canton H (1995) Serotonin receptors: signal transduction pathways. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 431–441
Schreiber G, Avissar S, Danon A, Belmaker RH (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 29: 273–280
Tan CH, Javors MA, Seleshi E, Lowrimore PA, Bowden CL (1990) Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sei 46: 1175–1180
Van Calker D, Foerstner U, Bohus M, Gebicke-Haerter P, Hecht H, Wark H-J, Berger M (1993) Increased sensitivity to agonist stimulation of the Ca2+ response in neutrophils of manic-depressive patients: effect of lithium therapy. Neuropsychobiology 27: 180–183
Yates M, Leake A, Candy JM, Fairbrairn AF, McKeith IG, Ferrier IN (1990) 5-HT2 receptor changes in major depression. Biol Psychiatry 27: 489–496
Young LT, Li PP, Kamble A, Siu KP, Warsh JJ (1994) Mononuclear leukocyte levels of G proteins with bipolar disorder or major depressive disorder. Am J Psychiatry 151: 594–596
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Tokyo
About this paper
Cite this paper
Kusumi, I., Koyama, T. (1998). Serotonin-2A Receptor Function in Affective Disorders. In: Ozawa, H., Saito, T., Takahata, N. (eds) Signal Transduction in Affective Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68479-4_3
Download citation
DOI: https://doi.org/10.1007/978-4-431-68479-4_3
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68481-7
Online ISBN: 978-4-431-68479-4
eBook Packages: Springer Book Archive