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The Biology of Ligament Reconstruction

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Reconstruction of the Knee Joint

Summary

Despite contemporary enthusiasm for ligament reconstruction procedures, only modest interest is evident in the literature with respect to the biology of ligament grafts. However, the long history of scientific investigation into tendon transplantation (tendons being the soft tissue most closely related to ligaments) contains numerous observations pertinent to the current interest in ligament transplantation. Both topics are reviewed, and encouraging evidence to support the ongoing scientific investigation into both tendon and ligament graft biology is described.

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References

  1. Peer LA (1955) Transplantation of tendon in humans. In: Peer LA (ed) Transplantation of tissues. Cartilage, bone, fascia, tendon, and muscle. Williams and Wilkins, Baltimore, pp 296–319

    Google Scholar 

  2. Peer LA (1955) Transplantation of tendon in animals. In: Peer LA (ed) Transplantation of tissues. Cartilage, bone, fascia, tendon, and muscle. Williams and Wilkins, Baltimore, pp 277–295

    Google Scholar 

  3. Amiel D, Frank CB, Harwood FL, Fronek J, Akeson WH (1983) Tendons and ligaments—A morphological and biochemical comparison. J Orthop Res 1:257–265

    Article  Google Scholar 

  4. Barth GP (1903) Tendon transplantation. Wisconsin Med J 1:180

    Google Scholar 

  5. Viering W (1891) Experimentelle untersuchung iber die regeneration des schnengewebes. Arch Pathol Anat 125:252

    Article  Google Scholar 

  6. Bougié R (1882) Greffe tendineuse. Bull Mem Soc Paris 27:193

    Google Scholar 

  7. Robson AWM (1888) A case of tendon grafting. Trans Clin Soc Lond 22:289

    Google Scholar 

  8. Lewis J, Davis CB (1911) Experimental direct transplantation of tendon and fascia. JAMA 57:540

    Article  Google Scholar 

  9. Potenza AD (1986) Philosophy of flexor tendon surgery. Orthop Clin North Am 17(3):349–352

    PubMed  CAS  Google Scholar 

  10. Helferich H (1882) Ueber muskeltransplantation beim mensehen. Verh Dtsch Ges Chir 11:2–212

    Google Scholar 

  11. Peyrot A (1886) Transplantation chez l’homme d’un tendon emprunté à un chien; guérison avec rétablissement partiel de la function. Bull Mem Soc Chir Par 12:356

    Google Scholar 

  12. Jalifier P (1920) Hé térogreffes morts de tendon. Lyon Chir 17:97

    Google Scholar 

  13. Monod L (1887) Plais de tendons–greffe tendineuse. Bull Mem Soc Med Hop 13:397

    Google Scholar 

  14. Rehn E (1924) The free transplantation of tendon. Neue Dtsch Chir 26:370

    Google Scholar 

  15. Hutchinson J (1923) Hernia and its radical cure. Froude and Hodder and Stroughton, London, pp 46–47 (Oxford medical publications)

    Google Scholar 

  16. Rehn E (1910) Die homoplastische schnentransplantation im tierexperiment. Beitr Klin Chir 68:417

    Google Scholar 

  17. Lange F (1927) Tendon transplantation. Surg Gynecol Obstet 44:455

    Google Scholar 

  18. Bloch JC, Bonnett P (1929) Evolution et traitement des plaies des tendons de la main. Congr Franc Chir 38:547

    Google Scholar 

  19. Koch SL (1933) Complicated contractures of the hand, their treatment by freeing fibrosed tendons and replacing destroyed tendons with grafts. Ann Surg 98:546–580

    Article  PubMed  CAS  Google Scholar 

  20. Murphy JB (1912) Contribution to surgery of bones, joints and tendons. JAMA 58:1660

    Article  Google Scholar 

  21. Kirschner M (1909) Ãœber freie sehnen- und fascientransplantation. Beitr Klin Chir 65:472

    Google Scholar 

  22. Hauck G (1924) Ueber schnenverletsungen, schnenregeneration und schnenenaht. Arch Klin Chir 128:568

    Google Scholar 

  23. Van Demark RE (1948) Tendon graft replacement of finger flexors. Lancet 68:259–261

    Google Scholar 

  24. Morganti (1939) Riparazzione chirugica di estese perdite tendinee. Chir D Org Movimento 25:182

    Google Scholar 

  25. Flynn JE (1949) Flexor tendon grafts in hand. N Engl J Med 241:807–812

    Article  PubMed  CAS  Google Scholar 

  26. Boyes JH (1950) Flexor tendon grafts in fingers and thumb; evaluation of end results. J Bone Joint Surg 32A:489–499

    Google Scholar 

  27. Peer LA, Walker JC (1951) The behavior of autogenous human tissue grafts; comparative study. Plast Reconstr Surg 7:6–23

    Article  CAS  Google Scholar 

  28. Harwood FL, Amiel D, Gelberman RH, Seiler JG (1993) Cellular expression of type I collagen mRNA in autogenous flexor tendon grafts: a comparison between intra- and extrasynovial donor tendons (abstract). Trans Orthop Res Soc 18:156

    Google Scholar 

  29. Peer LA (1955) Unpublished data. Cited in Peer LA (1955) Transplantation of tendon in humans. In: Peer LA (ed) Transplantation of tissues. Cartilage, bone, fascia, tendon and muscle. Williams and Wilkins, Baltimore, pp 296–319

    Google Scholar 

  30. Peer LA (1955) Transplantation of tissues. Cartilage, bone, fascia, tendon, and muscle. Willams and Wilkins, Baltimore

    Google Scholar 

  31. Neuhoff H (1923) The transplantation of tissues. Appleton, New York, pp 100–101

    Google Scholar 

  32. Peacock EE (1959) Morphology of homologous and heterologous tendon grafts. Surg Gynecol Obstet 109:735–742

    PubMed  Google Scholar 

  33. Peacock EE, Petty J (1960) Antigenicity of tendon. Surg Gynecol Obstet 110:187–192

    PubMed  Google Scholar 

  34. Flynn JE, Graham JH (1962) Healing following tendon suture and tendon transplants. Surg Gynecol Obstet 115:467–472

    PubMed  CAS  Google Scholar 

  35. Mason ML, Shearon CG (1932) The process of tendon repair; an experimental study of tendon suture and tendon graft. Arch Surg 25:615–692

    Article  Google Scholar 

  36. Cordrey LJ, McCorkle H, Hilton E (1963) A comparative study of fresh autogenous and preserved homogenous tendon grafts in rabbits. J Bone Joint Surg 45B:182–195

    Google Scholar 

  37. Andreef I, Dimoff G, Metschkarski S (1967) A comparative experimental study on transplantation of autogenous and homogenous tendon tissue. Acta Orthop Scand 38:35–44

    Article  Google Scholar 

  38. Lance EM, Fisher RL (1970) Transplantation of the rabbits’ patella. J Bone Joint Surg 52A(1):145–156

    Google Scholar 

  39. Cameron RR, Conrad RN, Sell KW, Latham WD (1971) Freeze-dried composite tendon allografts: an experimental study. Plast Reconstr Surg 47(1):39–46

    Article  PubMed  CAS  Google Scholar 

  40. Liu TK (1975) Transplantation of preserved composite tendon allografts. An experimental study in chickens. J Bone Joint Surg 57A(1):65–70

    Google Scholar 

  41. Potenza AD, Melone D (1978) Evaluation of freeze-dried flexor tendon grafts in dogs. J Hand Surg 3(2):157–162

    CAS  Google Scholar 

  42. Hey Groves EW (1917) Operation for the repair of the crucial ligaments. Lancet 2:674

    Article  Google Scholar 

  43. O’Donoghue DH (1963) A method for replacement of the anterior cruciate ligament of the knee. Report of twenty cases. J Bone Joint Surg 45A:905–924

    Google Scholar 

  44. Jones KG (1963) Reconstruction of the anterior cruciate ligament. A technique using the central one-third of the patellar ligament. J Bone Joint Surg 45A:925–932

    Google Scholar 

  45. Whiston TB, Walmsley R (1960) Some observations on the reaction of bone and tendon after tunnelling of bone and insertion of tendon. J Bone Joint Surg 42B:377–386

    Google Scholar 

  46. Forward AD, Cowan RJ (1963) Tendon suture to bone. J Bone Joint Surg 45A(4):807–823

    Google Scholar 

  47. Chiroff RT (1975) Experimental replacement of the anterior cruciate ligament. A histological and microradiographic study. J Bone Joint Surg 57A(8):1124–1127

    Google Scholar 

  48. Arnoczky SP, Tarvin GB, Marshall JL (1982) Anterior cruciate ligament replacement using patellar tendon: an evaluation of graft revascularization in the dog. J Bone Joint Surg 64A(2):217–224

    Google Scholar 

  49. Shino K, Kawasaki T, Hirose H, Gotoh I, Inoue M, Ono K (1984) Replacement of the anterior cruciate ligament by an allogeneic tendon graft. An experimental study in the dog. J Bone Joint Surg 66B:672–681

    Google Scholar 

  50. Nikolaou PK, Seaber AV, Glisson RR, Ribbeck BM, Bassett FH (1986) Anterior cruciate ligament allograft transplantation. Long-term function, histology, revascularization, and operative technique. Am J Sports Med 14:348–360

    Article  PubMed  CAS  Google Scholar 

  51. Jackson DW, Grood ES, Arnoczky SP, Butler DL, Simon TM (1987) Freeze dried anterior cruciate ligament allografts. Preliminary studies in a goat model. Am J Sports Med 15:295– 303 [Erratum in 15:482]

    Article  PubMed  Google Scholar 

  52. Horibe S, Shino K, Nakamura H, Tanaka M, Ono K (1990) Replacing the medial collateral ligament with an allogenic tendon graft. An experimental canine study. J Bone Joint Surg 72B(6):1044–1049

    Google Scholar 

  53. Jackson DW, Grood ES, Goldstein JD, Rosen MA, Kurzweil PR, Cummings JF, Simon TM (1993) A comparison of patellar tendon autograft and allograft used for anterior cruciate ligament reconstruction in the goat model. Am J Sports Med 21:176–185

    Article  PubMed  CAS  Google Scholar 

  54. Rodeo S, Arnoczky S, Torzilli P, Hidaka C, Warren R (1993) Tendon healing in a bone tunnel: a biomechanical and histologic study in the dog (abstract). Trans Orthop Res Soc 18:29

    Google Scholar 

  55. Sabiston CP, Frank CB, Lam TC, Shrive NG (1990) Allograft ligament transplantation. A morphological and biochemical evaluation of a medial collateral ligament complex in a rabbit model. Am J Sports Med 18(2):160–168

    Article  PubMed  CAS  Google Scholar 

  56. McMaster WC (1985) Bovine xenograft collateral ligament replacement in the dog. J Orthop Res 3:492–498

    Article  PubMed  CAS  Google Scholar 

  57. Webster DA, Werner FW (1983) Freeze-dried flexor tendons in anterior cruciate ligament reconstruction. Clin Orthop 181:238–243

    PubMed  Google Scholar 

  58. McMaster WC (1985) A histologic assessment of canine anterior cruciate substitution with bovine xenograft. Clin Orthop 196:196–201

    PubMed  Google Scholar 

  59. Amiel D, Kleiner JB, Akeson WH (1986) The natural history of the anterior cruciate ligament autograft of patellar tendon origin. Am J Sports Med 14:449–462

    Article  PubMed  CAS  Google Scholar 

  60. Kleiner JB, Amiel D, Harwood FL, Akeson WH (1989) Early histologic, metabolic and vascular assessment of anterior cruciate ligament autografts. J Orthop Res 7:235–242

    Article  PubMed  CAS  Google Scholar 

  61. Frank C, Edwards P, McDonald D, Bodie D, Sabiston P (1988) Viability of ligaments after freezing: an experimental study in a rabbit model. J Orthop Res 6:95–102

    Article  PubMed  CAS  Google Scholar 

  62. Jackson DW, Simon TM, Kurzweil PR, Rosen MA (1992) Survival of cells after intraarticular transplantation of fresh allografts of the patellar and anterior cruciate ligaments. DNA-probe analysis in a goat model. J Bone Joint Surg 74A:112–118

    Google Scholar 

  63. Yoshiya S, Andrish JT, Manley MT, Kurosaka M (1986) Augmentation of anterior cruciate ligament reconstruction in dogs with prostheses of different stiffnesses. J Orthop Res 4:475–485

    Article  PubMed  CAS  Google Scholar 

  64. McFarland EG (1986) The relationship of vascularity and water content to tensile strength in a patellar tendon replacement of the anterior cruciate in dogs. Am J Sports Med 14(6):436–448

    Article  PubMed  CAS  Google Scholar 

  65. Ballock PT, Woo SL, Lyon RM, Hollis JM, Akeson WH (1989) Use of patellar tendon autograft for anterior cruciate ligament reconstruction in the rabbit: a long-term histologic and biomechanical study. J Orthop Res 7:474–485

    Article  PubMed  CAS  Google Scholar 

  66. Decker B, Bosch U, Kasperczyk W, Oestern HJ, Reale E (1991) Ultrastructural changes of the patellar tendon as a cruciate ligament substitute (one-year and two-year results). J Submicrosc Cytol Pathol 23(1):9–21

    PubMed  CAS  Google Scholar 

  67. Bosch U, Decker B, Kasperczyk W, Nerlich A, Oestern HJ, Tscherne H (1992) The relationship of mechanical properties to morphology in patellar tendon autografts after posterior cruciate ligament replacement in sheep. J Biomech 25:821–830

    Article  PubMed  CAS  Google Scholar 

  68. Arnoczky SP, Warren RF, Ashlock MA (1986) Replacement of the anterior cruciate ligament using a patellar tendon allograft. An experimental study. J Bone Joint Surg 68A:376–385

    Google Scholar 

  69. Shino K, Inoue M, Horibe S, Nagano J, Ono K (1988) Maturation of allograft tendons transplanted into the knee. An arthroscopic and histological study. J Bone Joint Surg 70B:556–560

    Google Scholar 

  70. Shino K, Inoue M, Horibe S, Hamada M, Ono K (1990) Reconstruction of the anterior cruciate ligament using allogenic tendon. Long term follow-up. Am J Sports Med 18(5):457– 465

    Article  PubMed  CAS  Google Scholar 

  71. Rougraff B, Shelbourne KD, Gerth PK, Warner J (1993) Arthroscopic and histologic analysis of human patellar tendon autografts used for anterior cruciate ligament reconstruction. Am J Sports Med 21:277–284

    Article  PubMed  CAS  Google Scholar 

  72. Jackson DW, Grood ES, Arnoczky SP, Butler DL, Simon TM (1987) Cruciate reconstruction using freeze dried anterior cruciate ligament allograft and a ligament augmentation device (LAD). An experimental study in a goat model. Am J Sports Med 15:528–538

    Article  PubMed  CAS  Google Scholar 

  73. Shino K, Horibe S (1991) Experimental ligament reconstruction by allogenic tendon graft in a canine model. Acta Orthop Belg 57(suppl II):44–53

    PubMed  Google Scholar 

  74. Yin FCP, Tompkins WR, Peterson KL, Intaglietta M (1972) A video dimension analyser. IEEE Trans Biomed Eng 19(5):376–381

    Article  PubMed  CAS  Google Scholar 

  75. Kanatani Y, Hirohata K, Umetani T (1986) An autoradiographic study of the distribution of sensory nerve endings in the knee joint of the rat (in Japanese). Nippon Seikeigeka Gakkai Zasshi (J Jpn Orthop Assoc) 60:1283–1292

    CAS  Google Scholar 

  76. Kohn D (1990) Arthroscopic evaluation of anterior cruciate ligament reconstruction using a free patellar tendon autograft. A prospective, randomized study. Clin Orthop 254:220–224

    PubMed  Google Scholar 

  77. Aim A, Liljedahl SO, Strömberg B (1976) Clinical and experimental experience in reconstruction of the anterior cruciate ligament. Orthop Clin North Am 7(1): 181–189

    Google Scholar 

  78. Aim A, Strömberg B (1974) Vascular anatomy of the patellar and cruciate ligaments: a microangiographic and histologic investigation in the dog. Acta Chir Scand Suppl 445:25– 35

    Google Scholar 

  79. Vasseur PB, Stevenson S, Gregory CR, Rodrigo JJ, Pauli S, Heitter D, Sharkey N (1991) Anterior cruciate ligament allograft transplantation in dogs. Clin Orthop 269:295–304

    PubMed  Google Scholar 

  80. Vasseur PB, Rodrigo JJ, Stevenson S, Clark G, Sharkey N (1987) Replacement of the anterior cruciate ligament with a bone-ligament-bone anterior cruciate ligament allograft in dogs. Clin Orthop 219:268–277

    PubMed  Google Scholar 

  81. Minami A, Ishii S, Ogino T, Oikawa T, Kobayashi H (1982) Effects of immunological antigenicity of the allogeneic tendons on tendon grafting. Hand 19:111–119

    Google Scholar 

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© 1997 Springer-Verlag Tokyo

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Frank, C.B. (1997). The Biology of Ligament Reconstruction. In: Niwa, S., Yoshino, S., Kurosaka, M., Shino, K., Yamamoto, S. (eds) Reconstruction of the Knee Joint. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68464-0_5

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  • DOI: https://doi.org/10.1007/978-4-431-68464-0_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68466-4

  • Online ISBN: 978-4-431-68464-0

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