Abstract
A number of methods utilize the feeding artery of the tumor for the treatment of hepatocellular carcinoma (HCC); such methods include implantation of an infusion pump, placement of a catheter for injection into the artery, and embolization of the artery with gelatin-gel or microspheres containing anticancer agents. However, very few methods have exploited the use of lipid as a carrier and depository of an anticancer agent. Recently, we developed a procedure in which Lipiodol ultrafluid (Lipiodol) is used as a carrier of anticancer agents for injection into the feeding artery, a significant breakthrough in the treatment of solid tumors. The lipid lymphographic agent, Lipiodol, has been found to be selectively retained in HCC when injected into the hepatic artery [1]. In addition, a lipid contrast medium has various diagnostic applications, as described in this chapter. Anticancer agents, such as styrene maleic acid conjugates of neocarzinostatin (SMANCS) [2,3], mitomycin C (MMC), or aclarubicin (ACR), were dissolved into Lipiodol. As SMANCS/Lipiodol (LPD), MMC/LPD, ACR/LPD, or a mixture of these, these oily anticancer agents were administered by catheterization of the celiac or hepatic artery under X-ray monitor. Anticancer effects and the advantages of this targeting chemotherapy for HCC are described in the succeeding sections of this review.
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References
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© 1987 Springer Japan
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Konno, T., Maeda, H. (1987). Targeting Chemotherapy of Hepatocellular Carcinoma. In: Okuda, K., Ishak, K.G. (eds) Neoplasms of the Liver. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68349-0_27
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DOI: https://doi.org/10.1007/978-4-431-68349-0_27
Publisher Name: Springer, Tokyo
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