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Experimental and Epidemiological Studies on the Relation of Trace Elements in the Pathogenesis and Prevention of Cardiovascular Diseases

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Trace Elements in Clinical Medicine

Abstract

Review of previous experimental and epidemiological studies indicated some relationship of water quality with cardiovascular mortalities and the possible involvement of selenium in cardiomyopathy and of cadmium in hypertension. Present studies on rat models for hypertension, stroke and atherosclerosis revealed significant alterations in plasma and some organ contents of magnesium (Mg) among macroelements and of zinc (Zn) among microelements so far examined, suggestive of the possible involvement of these minerals in hypertension mechanisms, especially in its intracellular processes in addition to causative and preventive roles of macroelements such as sodium (Na), potassium (K) and calcium (Ca) that have been experimentally proven by our previous studies. In our world-wide epidemiological studies on cardiovascular diseases and nutrition, 24 hour urinalysis data of 5 Chinese populations showed not only correlation of Na but also inverse correlations of Ca and Mg with blood pressure. Moreover, comparative analysis on water quality in 6 populations with high and low cardiovascular mortalities has demonstrated Ca and/or Mg contents are obviously higher in those with low risks.

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Authors and Affiliations

  1. Department of Pathology, Shimane Medical University, Izumo, 693, Japan

    Yukio Yamori, Yasuo Nara & Ryoichi Horie

  2. WHO Collaborating Center for Research on Primary Prevention of CVD, Izumo, 693, Japan

    Yukio Yamori, Yasuo Nara & Ryoichi Horie

  3. College of Analytical Chemistry, Osaka, 530, Japan

    Fuji Morii

  4. Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, 160, Japan

    Taichiro Nishima

  5. Department of Hygiene, Jichi Medical School, Tochigi, 329-04, Japan

    Hiroko Nomiyama & Kazuo Nomiyama

Authors
  1. Yukio Yamori
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  2. Yasuo Nara
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  3. Ryoichi Horie
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  4. Fuji Morii
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  5. Taichiro Nishima
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  6. Hiroko Nomiyama
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  7. Kazuo Nomiyama
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Editors and Affiliations

  1. Department of Otorhinolaryngology, Nihon University School of Medicine, 173, Ohyaguchi, Itabashi-ku Tokyo, Japan

    Hiroshi Tomita M.D. (Professor and Chairman) (Professor and Chairman)

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© 1990 Springer-Verlag Tokyo

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Yamori, Y. et al. (1990). Experimental and Epidemiological Studies on the Relation of Trace Elements in the Pathogenesis and Prevention of Cardiovascular Diseases. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_7

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  • DOI: https://doi.org/10.1007/978-4-431-68120-5_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68122-9

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