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ST3Gal-V (GM3 Synthase, SAT-I)

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Handbook of Glycosyltransferases and Related Genes

Abstract

ST3Gal-V (GM3 synthase) belongs to the sialyltransferase family, and is a unique enzyme among all sialyltransferases so far identified since it is specifically involved in ganglioside GM3 formation. Since GM3 is a common precursor of almost all gangliosides (especially ganglio-series gangliosides), GM3 synthase plays an important role in the biosynthesis of more complex gangliosides, and primarily regulates the amount of GM3. As is found in all members of the sialyltransferase family, the cloned ST3Gal-Vs from different animal origins encode type II membrane proteins with two conserved regions, i.e., sialylmotifs L and S, although an invariant aspartic acid residue in sialylmotif Ls of all other sialyltransferases is characteristically replaced by histidine residue (Ishii et al. 1998; Kono et al. 1998; Fukumoto et al. 1999).

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Authors and Affiliations

  1. Department of Oncology and Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo, 204-8588, Japan

    Masaki Saito

  2. Virology and Glycobiology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Masaki Saito & Atsushi Ishii

Authors
  1. Masaki Saito
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  2. Atsushi Ishii
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Saito, M., Ishii, A. (2002). ST3Gal-V (GM3 Synthase, SAT-I). In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_39

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_39

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

  • eBook Packages: Springer Book Archive

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