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Sympathetic Control of Sweating and Cutaneous Active Vasodilatation

  • Chapter
Thermotherapy for Neoplasia, Inflammation, and Pain

Summary

Eccrine sweat glands are innervated by postganglionic cholinergic fibers. Activities of these fibers, which can be percutaneously recorded as multiunit burst activities using a microelectrode technique, are controlled by central mechanisms. There are two distinctive central mechanisms for sweating. The central mechanism that governs the sweat glands in the general body surface, except the palm and the sole, involves the detection of local temperature and the integration of thermal and nonthermal signals. The preoptic and anterior hypothalamus is an important region for these functions. The thermal signals from various sites of the body (including the CNS and the skin) are integrated at thermosensitive neurons in these areas, and sudomotor signals are generated. Nonthermal signals also converge to these neurons to modify the thermosensitivity of the central mechanism and, thus, the sudomotor outflow. In this way, they contribute to the preservation of homeostasis in situations of competition between thermal and nonthermal drives. The central mechanism that governs the skin of the palm and the sole probably involves several CNS structures including the reticular formation, limbic system, and neocortex. Mental stimuli not only elicit responses in sudomotor nerve activity destined for the palm and the sole, but also influence the central mechanism for generalized sweating to alter sudomotor outflow to the general body surface. Several neuropeptides are found in the nerve terminals around the sweat gland. These peptides may have a role in increasing local blood flow. The hypothesis has been proposed that sudomotor efferents also mediate active cutaneous vasodilatation.

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References

  1. Kuno Y (1956) Human perspiration. Thomas, Springfield

    Google Scholar 

  2. Kennedy WR, Wendelschafer-Crab G, Brelje TC (1994) Innervation and vasculature of human sweat glands: an immunohistochemistry-laser scanning confocal fluorescence microscopy study. J Neurosci 14: 6825–6833

    PubMed  CAS  Google Scholar 

  3. Jenkinson DM, Montogomery I, Elder HY (1978) Studies on the nature of the peripheral sudomotor control mechanism. J Anat 125: 625–639

    PubMed  CAS  Google Scholar 

  4. Rechardt L, Waris T, Rintala A (1976) Innervation of human axillary sweat glands. Histochemical and electron microscopic study of hyperhidrotic and normal subjects. Scand J Reconstr Surg 10: 107–112

    Article  CAS  Google Scholar 

  5. Tainio H, Vaalasti A (1988) Electron microscopic study on the innervation of the human axillary sweat glands. Acta Histochem 83: 167–171

    Article  PubMed  CAS  Google Scholar 

  6. Montagna W (1960) Cholinesterases in the cutaneous nerves of man. In: Montagna W (ed) Advances in biology of skin, vol I. Cutaneous innervation. Pergamon, Oxford, pp 74–87

    Google Scholar 

  7. Uno H, Montagna W (1977) Sympathetic innervation of the sweat glands and piloarrector muscles of macaques and human beings. J Invest Dermatol 69: 112–120

    Article  PubMed  CAS  Google Scholar 

  8. Sato K (1977) The physiology, pharmacology, and biochemistry of the eccrine sweat gland. Rev Physiol Biochem Pharmacol 79: 51–131

    Article  PubMed  CAS  Google Scholar 

  9. Landis SC, Keefe D (1983) Evidence for neurotransmitter plasticity in vivo: developmental changes in properties of cholinergic sympathetic neurons. Dev Biol 98: 349–372

    Article  PubMed  CAS  Google Scholar 

  10. Tainio H, Vaalasti A, Rechhardt L (1987) The distribution of substance P-, CGRP-, galanin-and ANP-like immunoreactive nerves in human sweat glands. Histochem J 19: 375–380

    Article  PubMed  CAS  Google Scholar 

  11. Vaalasti A, Tainio H, Rechardt L (1985) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the nerves of human axillary sweat glands. J Invest Dermatol 85: 246–248

    Article  PubMed  CAS  Google Scholar 

  12. Schmitt M, Kummer W, Heym C (1988) Calcitonin gene-related peptide (CGRP)-immunoreactive neurons in the human cervico-thoracic paravertebral ganglia. J Chem Neuroanat 1: 287–292

    PubMed  CAS  Google Scholar 

  13. Lindh B, Haegerstrand A, Lundberg JM, et al (1988) Substance P-, VIP-, and CGRP-like immunoreactivities coexist in a population of cholinergic postganglionic sympathetic nerves innervating sweat glands in the cat. Acta Physiol Scand 134: 569–570

    Article  PubMed  CAS  Google Scholar 

  14. Riedl B, Nischik M, Birklein F, et al (1998) Spatial extension of sudomotor axon reflex sweating in human skin. J Auton Nery Syst 69: 83–88

    Article  CAS  Google Scholar 

  15. Schmelz M, Schmidt R, Bickel A, et al (1998) Innervation territories of single sympathetic C fibers in human skin. J Neurophysiol (Bethesda) 79: 1653–1660

    CAS  Google Scholar 

  16. Szabó G (1962) The number of eccrine sweat glands in human skin. In: Montagna W, Ellis RA, Silver AF (eds) Advances in biology of skin, vol III. Eccrine sweat glands and eccrine sweating. Pergamon, Oxford, pp 1–5

    Google Scholar 

  17. Kennedy WR, Sakuta M, Quick DC (1984) Rodent eccirne sweat glands: a case of multiple efferent innervation. Neuroscience 11: 741–749

    Article  PubMed  CAS  Google Scholar 

  18. Nishiyama T, Ogawa T, Sugenoya J, et al (1994) Videomicroscopic observation on activity of individual sweat glands in palm (in Japanese). Jpn J Biometeorol 31: 175–182

    Google Scholar 

  19. Sato K, Sato F (1983) Individual variations in structure and function of human eccrine sweat gland. Am J Physiol 245: R203 - R208

    PubMed  CAS  Google Scholar 

  20. Ogawa T, Sugenoya J (1993) Pulsatile sweating and sympathetic sudomotor activity. Jpn J Physiol 43: 275–289

    Article  PubMed  CAS  Google Scholar 

  21. Hagbarth K-E, Hallin RG, Hongel A, et al (1972) General characteristics of sympathetic activity in human skin nerves. Acta Physiol Scand 84: 164–176

    Article  PubMed  CAS  Google Scholar 

  22. Bini G, Hagbarth K-E, Hynninen P, et al (1980) Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol (Lond) 306: 537–552

    CAS  Google Scholar 

  23. Bini G, Hagbarth K-E, Hynninen P, et al (1980) Regional similarities and differences in thermoregulatory vaso-and sudomotor tone. J Physiol (Lond) 306: 553–565

    CAS  Google Scholar 

  24. Iwase S, Mano T, Sugenoya J, et al (1988) Relationship among skin sympathetic nerve activity, sweating, and skin blood flow. Environ Med 32: 55–67

    Google Scholar 

  25. Sugenoya J, Iwase S, Mano T, et al (1990) Identification of sudomotor activities in cutaneous sympathetic nerves using sweat expulsion as the effector responses. Eur J Appl Physiol 61: 302–308

    Article  CAS  Google Scholar 

  26. Schondorf R (1997) Skin potentials: normal and abnormal. In: Low PA (ed) Clinical autonomic disorders, 2nd edn. Lippincott-Raven, Phiadelphia, pp 221–231

    Google Scholar 

  27. Ogawa T, Terada E, Kobayashi M, et al (1965) Variations of the eccrine conductivity of the skin in relation to sweating. Jpn J Physiol 15: 296–309

    Article  Google Scholar 

  28. Edelberg R (1968) Biopotentials from the skin surface: the hydration effect. Ann NY Acad Sci 148: 252–262

    Article  PubMed  CAS  Google Scholar 

  29. Edelberg R (1964) Effect of vasoconstriction on galvanic skin response amplitude. J Appl Physiol 19: 427430

    Google Scholar 

  30. Edelberg R (1964) Independence of galvanic skin response amplitude and sweat production. J Invest Dermatol 42: 443–448

    PubMed  CAS  Google Scholar 

  31. Kunimoto M, Kirnö K, Elam M, et al (1991) Neuroeffector characteristics of sweat glands in the human hand activated by regular neural stimuli. J Physiol (Lond) 442: 391–411

    CAS  Google Scholar 

  32. Nishiyama T, Sugenoya J, Iwase S, et al (1998) Relationship of skin potential response on the sole to sudomotor nerve activity estimated by microneurography (abstract). Jpn J Physiol 48 (suppl): S177

    Google Scholar 

  33. Ogawa T, Bullard RW (1972) Characteristics of sub threshold sudomotor neural impulses. J Appl Physiol 33: 300–305

    PubMed  CAS  Google Scholar 

  34. Ogawa T, Asayama M, Ito M (1977) Comparison of sudomotor neural activities between palmar and nonpalmar sweating. Proc Int Congr Neuroveget Res 18: 236–238

    Google Scholar 

  35. McIntyre BA, Bullard RW, Banerjee M, et al (1968) Mechanism of enhancement of eccrine sweating by localized heating. J Appl Physiol 25: 255–260

    Google Scholar 

  36. Nadel ER, Mitchell JW, Saltin B, et al (1971) Peripheral modifications to the central drive for sweating. J Appl Physiol 31: 828–833

    PubMed  CAS  Google Scholar 

  37. Ogawa T (1975) Thermal influence on palmar sweating and mental influence on generalized sweating in man. Jpn J Physiol 25: 525–536

    Article  PubMed  CAS  Google Scholar 

  38. Okamoto T, Iwase S, Sugenoya J, et al (1994) Different thermal dependency of cutaneous sympathetic outflow to glabrus and hairy skin in humans. Eur J Appl Physiol 68: 460–464

    Article  CAS  Google Scholar 

  39. Nordin M (1990) Sympathetic discharges in the human supraorbital nerve and their relation to sudo-and vasomotor responses. J Physiol (Lond) 423: 241–255

    CAS  Google Scholar 

  40. Delius W, Hagbarth K-E, Hongel A, et al (1972) Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol Scand 84: 177–186

    Article  PubMed  CAS  Google Scholar 

  41. Vallbo AB, Hagbarth K-E, Torebjörk HE, et al (1979) Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919–957

    PubMed  CAS  Google Scholar 

  42. Saito H, Kogure K (1986) Sudomotor deficits in unilateral brain stem lesions: studies on central sympathetic pathways. Auton Nery Syst 23: 303–312

    Google Scholar 

  43. Nathan PW, Smith MC (1987) The location of descending fibers to sympathetic preganglionic vasomotor and sudomotor neurons in man. J Neurol Neurosurg Psychiatry 50: 1253–1262

    Article  PubMed  CAS  Google Scholar 

  44. Wallin B, Rea R (1988) Spinal sympathetic conduction velocity in humans. J Auton Nerv Syst 24: 221–225

    Article  PubMed  CAS  Google Scholar 

  45. Janig W, Szulczyk P (1981) The organization of lumber preganglionic neurons. J Auton Nery Syst 3: 177–191

    Article  CAS  Google Scholar 

  46. Fagius J, Wallin BG (1980) Sympathetic reflex latencies and conduction velocities in normal man. J Neurol Sci 47: 433–448

    Article  PubMed  CAS  Google Scholar 

  47. Takagi K, SakuriT (1950) A sweat reflex due to pressure on the body surface. Jpn J Physiol 1: 22–28

    Google Scholar 

  48. Ogawa T, Asayama M, Miyagawa T (1981) Dermatomal inhibition of sweating by skin pressure. In: Szelényi Z, Székely M (eds) Advances in physiological sciences, vol 32. Contributions to thermal physiology. Pergamon Press-Akadémiai Kiadó, Budapest, pp 413–415

    Google Scholar 

  49. Sugiyama Y, Watanabe T, Takeuch S, et al (1992) Asymmetric discharges of skin sympathetic nerve in humans with special reference to pressure hemihidrosis. Environ Med 36: 207–210

    Google Scholar 

  50. Hori T (1991) An update on thermosensitive neurons in the brain: from cellular biology to thermal and non-thermal homeostatic functions. Jpn J Physiol 41: 1–22

    Article  PubMed  CAS  Google Scholar 

  51. Simon E, Pierau F-K, Taylor DCM (1986) Central and peripheral thermal control of effectors in homeothermic temperature regulatoin. Physiol Rev 66: 235–300

    PubMed  CAS  Google Scholar 

  52. Hensel H (1981) Thermoreception and temperature regulation. Academic Press, London, pp 90–154

    Google Scholar 

  53. Wyndham CH, Atkins AR (1968) A physiological scheme and methematical model of temperature regulation in man. Pflügers Arch 303: 14–30

    Article  PubMed  CAS  Google Scholar 

  54. Boulant JA, Hardy JD (1974) The effect of spinal and skin temperatures on the firing rate and thermosensitivity of preoptic neurones. J Physiol (Lond) 240: 639–660

    CAS  Google Scholar 

  55. Sugenoya J, Ogawa T (1985) Characteristics of central sudomotor mechanism estimated by frequency of sweat expulsions. Jpn J Physiol 35: 783–794

    Article  PubMed  CAS  Google Scholar 

  56. Nadel ER, Bullard RW, Stolwijk JAJ (1971) Importance of skin temperature in the regulation of sweating. J Appl Physiol 31: 80–87

    PubMed  CAS  Google Scholar 

  57. Macefield VG, Wallin BG (1996) The discharge behaviour of single sympathetic neurones supplying human sweat glands. J Auton Nery Syst 61: 277–286

    Article  CAS  Google Scholar 

  58. Kunimoto M, Kirnö K, Elam M, et al (1991) Neuro-effector characteristics of sweat glands in the human hand activated by irregular stimuli. Acta Physiol Scand 146: 261–269

    Article  Google Scholar 

  59. Silva NL, Boulant JA (1984) Effects of osmotic pressure, glucose, and temperature on neurons in preoptic tissue slices. Am J Physiol 247: R335 - R345

    PubMed  CAS  Google Scholar 

  60. Hori T, Katafuchi T (1998) Cell biology and the functions of thermorsensitive neurons in the brain. In: Sharma HS, Westman J (eds) Progress in brain research, vol 115. Elsevier, Amsterdam, pp 9–23

    Google Scholar 

  61. Fortney SM, Wenger CB, Bove, et al (1984) Effect of hyperosmolality in control of blood flow and sweating. J Appl Physiol 57: 1688–1695

    PubMed  CAS  Google Scholar 

  62. Nakashima T, Hon T, Kiyohara T, Shibata M (1985) Omosensitivity of preoptic thermosensitive neurons in hypothalamic slices in vitro. Pflügers Arch 405: 112–117

    Article  PubMed  CAS  Google Scholar 

  63. Koga H, Hori T, Inoue T, et al (1987) Convergence of hepatoportal osmotic and cardiovascular signals on pre-optic thermosensitive neurons. Brain Res Bull 19: 109–113

    Article  PubMed  CAS  Google Scholar 

  64. Fortney SM, Nadel ER, Wenger CB, et al (1981) Effects of blood volume on sweating rate and body fluids in exercising humans. J Appl Physiol 51: 1594–1600

    PubMed  CAS  Google Scholar 

  65. Dodt C, Gunnarsson T, Elam M, et al (1995) Central blood volume influences sympathetic sudomotor nerve traffic in warm humans. Acta Physiol Scand 155: 41–51

    Article  PubMed  CAS  Google Scholar 

  66. Solak SD, Brengelmann GL, Freund PR (1985) Sweat vs. forearm blood flow during lower body negative pressure. J Appl Physiol 58: 1546–1552

    Google Scholar 

  67. Vissing SF, Scherrer U, Victor RG (1994) Increase of sympathetic discharge to skeletal muscle but not to skin during mild lower body negative pressure in humans J Physiol (Camb) 481: 233–241

    CAS  Google Scholar 

  68. Mack G, Nishiyasu T, Shi X (1995) Baroreceptor modulation of cutaneous vasodilator and sudomotor responses to thermal stress in humans. J Physiol (Camb) 483: 537–547

    CAS  Google Scholar 

  69. Thornton SN, Beaurepaire RD, Nicolaidis S (1984) Electrophysiological investigation of cells in the region of the anterior hypothalamus firing in relation to blood pressure and volaemic changes. Brain Res 299: 1–7

    Article  PubMed  CAS  Google Scholar 

  70. Koga H, Hori T, Kiyohara T, et al (1987) Responses of preoptic thermosensitive neurons to changes in blood flow. Brain Res Bull 18: 749–755

    Article  PubMed  CAS  Google Scholar 

  71. Bini G, Hagbarth K-E, Wallin BG (1981) Cardiac rhythmicity of skin sympathetic activity recorded from peripheral nerves in man. J Auton Nery Syst 4: 17–24

    Article  CAS  Google Scholar 

  72. Berne C, Fagius J (1986) Skin nerve sympathetic activity during insulin-induced hypoglycaemia. Diabetologia 29: 855–860

    Article  PubMed  CAS  Google Scholar 

  73. Bullard RW (1964) Effects of carbon dioxide inhalation on sweating. J Appl Physiol 19: 137–141

    PubMed  CAS  Google Scholar 

  74. Matsumura K, Nakayama T, Kaminaga T (1987) Effects of carbon dioxide on preoptic thermosensitive neurons in vitro. Pflügers Arch 408: 120–123

    Article  PubMed  CAS  Google Scholar 

  75. Tamaki Y, Nakayama T, Kanosue K (1989) Effects of peripheral chemo-and baro-receptor denervation on responses of preoptic thermosensitive neurons to inspired CO2. Pflügers Arch 414: 495–499

    Article  PubMed  CAS  Google Scholar 

  76. Ogawa T, Satoh T, Takagi K (1967) Sweating during night sleep. Jpn J Physiol 17: 135–148

    Article  PubMed  CAS  Google Scholar 

  77. Sagot JC, Amoros C, Candas V, et al (1987) Sweating responses and body temperatures during nocturnal sleep in humans. Am J Physiol 252: R462 - R470

    PubMed  CAS  Google Scholar 

  78. Satinoff F (1978) Neural organization and evolution of thermal regulation in mammals. Science 201: 16–22

    Article  PubMed  CAS  Google Scholar 

  79. Noll G, Elam M, Kunimoto M, et al (1994) Skin sympathetic nerve activity and effector function during sleep in humans. Acta Physiol Scand 151: 319–329

    Article  PubMed  CAS  Google Scholar 

  80. Takeuchi S, Iwase S, Mano T, et al (1994) Sleep-related changes in human muscle and skin sympathetic nerve activities. J Auton Nery Syst 47: 121–129

    Article  CAS  Google Scholar 

  81. Kodama Y, Iwase S, Mano T, et al (1998) Attenuation of regional differentiation of sympathetic nerve activity during sleep in humans. J Auton Nery Syst 74: 126133

    Google Scholar 

  82. Yamazaki F, Kondo N, Ikegami H (1991) The role of central and peripheral mechanisms in the sweat rate change during exercise (in Japanese). Jpn J Biometeorol 28: 95–106

    Google Scholar 

  83. Ohnishi N, Ogawa T, Sugenoya J, et al (1994) Central motor command affects the sweating activity during exercise. In: Temperature regulation. Advances in pharmacological sciences. Birkhäuser, Basel, pp 183–187

    Google Scholar 

  84. Kondo N, Tominaga H, Shibasaki M, et al (1999) Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans. J Physiol (Camb) 515: 591–598

    Article  CAS  Google Scholar 

  85. Vissing SF, Scherrer U, Victor RG (1991) Stimulation of skin sympathetic nerve discharge by central command: differential control of sympathetic outflow to skin and skeletal muscle during static exercise. Circ Res 69: 228–238

    Article  PubMed  CAS  Google Scholar 

  86. Vissing SF, Hjorts0 EM (1996) Central motor command activates sympathetic outflow to the cutaneous circulation in humans. J Physiol (Camb) 492: 931–939

    CAS  Google Scholar 

  87. Vissing SF (1997) Differential activation of sympathetic discharge to skin and skeletal muscle in humans. Acta Physiol Scand Suppl 639: 1–32

    PubMed  CAS  Google Scholar 

  88. Saito M, Naito M, Mano T (1990) Different responses in skin and muscle sympathetic nerve activity to static muscle contraction. J Appl Physiol 69: 2085–2090

    PubMed  CAS  Google Scholar 

  89. Hori T, Kiyohara T, Shibata M, et al (1986) Responsiveness of monkey preoptic thermosensitive neurons to non-thermal emotional stimuli. Brain Res Bull 17: 75–82

    Article  PubMed  CAS  Google Scholar 

  90. Wang GH (1964) The neural control of sweating. University of Wisconsin Press, Madison

    Google Scholar 

  91. Davison MA, Koss MC (1975) Brain loci for activation of electrodermal response in the cat. Am J Physiol 229: 930–934

    PubMed  CAS  Google Scholar 

  92. Roy JC, Sequeira H, Delerm B (1993) Neural control of electrodermal activity: spinal and reticular mechanisms. In: Roy JC, Boucsein W, Fowles DC, et al (eds) Progress in electrodermal research. Plenum, New York, pp 73–92

    Chapter  Google Scholar 

  93. Yokota T, Sato A, Fujimori B (1963) Analysis of inhibitory influence of bulbar reticular formation upon sudomotor activity. Jpn J Physiol 13: 145–154

    Article  PubMed  CAS  Google Scholar 

  94. Yokota T, Sato A, Fujimori B (1963) Inhibition of sympathetic activity by stimulation of limbic system. Jpn J Physiol 13: 137–143

    Google Scholar 

  95. Cannon TD, Fuhrmann M, Mednick SA, et al (1988) Third ventricle enlargement and reduced electrodermal responsiveness. Psychophysiology 25: 153–156

    Article  PubMed  CAS  Google Scholar 

  96. Bagshaw MH, Kimble DP, Pribram KH (1965) The GSR of monkeys during orienting and habituation and after ablation of the amygdala, hipocampus and inferotemporal cortex. Neuropsychologia 3: 111–119

    Article  Google Scholar 

  97. Bechara AB, Tranel D, Damasio H, et al (1995) Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269: 1115–1118

    Article  PubMed  CAS  Google Scholar 

  98. Raine A, Reynolds GP, Sheard C (1991) Neuroanatomical correlates of skin conductance orienting in normal humans: a magnetic resonance imaging study. Psychophysiology 28: 548–558

    Article  PubMed  CAS  Google Scholar 

  99. Tranel D, Damasio H (1989) Intact electrodermal skin conductance responses after bilateral amygdala damage. Neuropsychologia 27: 381–390

    Article  PubMed  CAS  Google Scholar 

  100. Tranel D, Hyman BT (1990) Neuropsychological correlates of bilateral amygdala damage. Arch Neurol 47: 349–355

    Article  PubMed  CAS  Google Scholar 

  101. Tranel D, Damasio H (1994) Neuroanatomical correlates of electrodermal skin conductance responses. Psychophysiology 31: 427–438

    Article  PubMed  CAS  Google Scholar 

  102. Mangina CA, Beuzeron-Mangina JH (1996) Direct electrical stimulation of specific human brain structures and bilateral electrodermal activity. Int J Psychophysiol 22: 1–8

    Article  PubMed  CAS  Google Scholar 

  103. Homma S, Nakajima Y, Toma S, et al (1998) Intracerebral source localization of mental process-related potentials elicited prior to mental sweting response in humans. Neurosci Lett 247: 25–28

    Article  PubMed  CAS  Google Scholar 

  104. Wang GH, Brown VW (1956) Suprasegmental inhibition of an autonomic reflex. J Neurophysiol (Bethesda) 19: 564–572

    Google Scholar 

  105. Grueninger WE, Kimble DP, Grueninger J, et al (1965) GSR and corticosteroid response in monkeys with frontal ablations. Neuropsychology 3: 205–216

    Article  Google Scholar 

  106. Knight RT (1984) Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalogr Clin Neurophysiol 59: 9–20

    Article  PubMed  CAS  Google Scholar 

  107. Sourek K (1965) The nervous control of skin potentials in man. Nakladatelstvf Ceskoslovenské Akademie Ved, Praha

    Google Scholar 

  108. Lundberg JM, Hökfelt T, Schultzberg M, et al (1979) Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: evidence from combined immunohistochemistry and acethyicholinesterase staining. Neuroscience 4: 1539–1559

    Article  PubMed  CAS  Google Scholar 

  109. Lundberg JM, Änggfird A, Fahrenkrug J, et al (1980) Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilatation and secretion. Proc Natl Acad Sci USA 77: 1651–1655

    Article  PubMed  CAS  Google Scholar 

  110. Sato K, Sato F (1987) Effect of VIP on sweat secretion and cAMP accumulation in isolated simian eccrine glands. Am J Physiol 253: R935 - R941

    PubMed  CAS  Google Scholar 

  111. Sugenoya J, Ogawa T, Imai K, et al (1995) Cutaneous vasodilatation responses synchronize with sweat expulsions. Eur J Appl Physiol 71: 33–40

    Article  CAS  Google Scholar 

  112. Sugenoya J, Iwase S, Mano T, et al (1998) Vasodilator component in sympathetic nerve activity destined for the skin of the dorsal foot of mildly heated humans. J Physiol (Camb) 507: 603–610

    Article  CAS  Google Scholar 

  113. Kumazawa K, Sobue G, Mitsuma T, et al (1994) Modulatory effects of calcitonin gene-related peptide and substance P on human cholinergic sweat secretion. Clin Auton Res 4: 319–322

    Article  PubMed  CAS  Google Scholar 

  114. Yamashita Y, Ogawa T, Ohnishi N, et al (1987) Local effect of vasoactive intestinal polypeptide on human sweat gland function. Jpn J Physiol 37: 929–936

    Article  PubMed  CAS  Google Scholar 

  115. Yamashita Y, Ogawa T, Sugenoya J, et al (1989) Effects of trial natriuretic peptides on human sweating activity (in Japanese). Auton Nery Syst 26: 523–530

    Google Scholar 

  116. Roddie IC (1983) Circulation to skin and adipose tissue. In: Shepard JT, Abboud FM (eds) Handbook of physiology. The cardiovascular system, vol III, part 1. American Physiological Society, Bethesda, pp 285–317

    Google Scholar 

  117. Rowell LB (1981) Active neurogenic vasodilatation in man. In: Vanhoutte PM, Leusen I (eds) Vasodilatation. Raven Press, New York, pp 1–17

    Google Scholar 

  118. Love AH, Shanks RG (1962) The relationship between the onset of sweating and vasodilatation in the forearm during body heating. J Physiol (Lond) 162: 121–128

    CAS  Google Scholar 

  119. Kolka MA, Stephenson LA (1987) Cutaneous blood flow and local sweating after systemic atropine administration. Pflügers Arch 410: 524–529

    Article  PubMed  CAS  Google Scholar 

  120. Kellogg DL, Pergola PE, Piest KL, et al (1995) Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res 77: 1222–1228

    Article  PubMed  CAS  Google Scholar 

  121. Johnson JM, Proppe DW (1996) Cardiovascular adjustments to heat stress. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology, sect 4. Environmental physiology, vol I. Oxford University Press, New York, pp 215–243

    Google Scholar 

  122. Bell C, Jänig W, Kümmel H, et al (1985) Differentiation of vasodilator and sudomotor resonses in the cat paw pad to preganglionic sympathetic stimulation. J Physiol (Lond) 364: 93–104

    CAS  Google Scholar 

  123. Gregor M, Jänig W, Riedel W (1976) Response pattern of cutaneous postganglionic neurones to the hindlimb in spinal cord heating and cooling in the cat. Pflügers Arch 363:135–140

    Google Scholar 

  124. Grewe W, Jänig W, Kummel H (1995) Effects of hypothalamic thermal stimuli on sympathetic neurones innervating skin and skeletal muscle of the cat hindlimb J Physiol (Camb) 488: 139–152

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Aichi Medical University, Nagakute-cho, Aichi, 480-1195, Japan

    Junichi Sugenoya, Takaaki Matsumoto, Tetsunari Nishiyama & Yoko Sakamoto

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  1. Junichi Sugenoya
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  2. Takaaki Matsumoto
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  3. Tetsunari Nishiyama
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  4. Yoko Sakamoto
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Editors and Affiliations

  1. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852-8523, Nagasaki, Japan

    Mitsuo Kosaka

  2. Health Research Foundation, 606-8225, Kyoto, Japan

    Tsutomu Sugahara

  3. Clinic of Rheumatology, Physical Medicine, and Balneology, University of Giessen, Bad Nauheim, Germany

    Klaus L. Schmidt

  4. Max Planck Institute for Physiological and Clinical Research, W.G. Kerckhoff Institute, Bad Nauheim, Germany

    Eckhart Simon

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Sugenoya, J., Matsumoto, T., Nishiyama, T., Sakamoto, Y. (2001). Sympathetic Control of Sweating and Cutaneous Active Vasodilatation. In: Kosaka, M., Sugahara, T., Schmidt, K.L., Simon, E. (eds) Thermotherapy for Neoplasia, Inflammation, and Pain. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67035-3_20

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  • DOI: https://doi.org/10.1007/978-4-431-67035-3_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67037-7

  • Online ISBN: 978-4-431-67035-3

  • eBook Packages: Springer Book Archive

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