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Drebrin and Spine Formation

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Drebrin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1006))

Abstract

Dendritic spines are the postsynaptic receptive regions of most excitatory synapses in the central nervous system. Thus, spines are supposed to act as a fundamental unit for information processing of the brains. Previous studies have demonstrated the roles of drebrin in the formation of dendritic spines and in the recruitment of synaptic proteins to postsynaptic sites. Further, a live imaging study has revealed the unique dynamics of drebrin in dendritic spines, which help to understand how drebrin is involved in dendritic spine formation. This review will provide a basic knowledge about dendritic spine and overview recent progresses in understanding of the roles of drebrin in dendritic spine morphogenesis and synaptogenesis.

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Authors and Affiliations

  1. Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, H2W 1R7, Canada

    Hideto Takahashi & Yusuke Naito

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  1. Hideto Takahashi
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  2. Yusuke Naito
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Correspondence to Hideto Takahashi .

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Editors and Affiliations

  1. Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Tomoaki Shirao

  2. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

    Yuko Sekino

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Takahashi, H., Naito, Y. (2017). Drebrin and Spine Formation. In: Shirao, T., Sekino, Y. (eds) Drebrin. Advances in Experimental Medicine and Biology, vol 1006. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56550-5_10

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