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Bone Marrow-Derived Mononuclear Cells

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Cell Therapy Against Cerebral Stroke

Abstract

Stem cell-based approaches have recently attracted much attention owing to their potential therapeutic effects in patients with stroke. Bone marrow-derived mononuclear cells (MNCs), a source of stem cells, contain populations of lymphocytes, mesenchymal and hematopoietic stem cells, and hematopoietic and endothelial progenitor cells. They can be rapidly harvested from the bone marrow, separated, isolated, and then returned back into the animal or human. Experimental studies have demonstrated that the beneficial effects of MNCs may occur due to neuroprotection, modulation of inflammation and the immune response, endogenous neurogenesis, arteriogenesis, and angiogenesis. Several clinical studies have shown the safety and efficacy of MNCs in patients with ischemic stroke. Therefore, MNC treatment is a potentially attractive candidate to promote stroke recovery. Further studies are required to develop therapeutic strategies for improved protection against stroke and optimal transplantation protocols, such as cell dose, timing, delivery route, patient selection (age, gender, comorbidities, stroke subtype, and location), and combination therapy.

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Acknowledgments

I would like to thank Dr. Kazumi Kimura and Chikako Nito for critical feedback on the manuscript. This manuscript was supported by a grant from the Nippon Medical School Alumni Association.

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  1. Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan

    Satoshi Suda M.D., Ph.D.

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Correspondence to Satoshi Suda M.D., Ph.D. .

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Editors and Affiliations

  1. Hokkaido University Graduate School of M, Department of Neurosurgery, Sapporo, Hokkaido, Japan

    Kiyohiro Houkin

  2. Okayama University Graduate School of Me, Department of Neurology, Okayama, Okayama, Japan

    Koji Abe

  3. Graduate School of Medicine and Pharmace, Department of Neurosurgery, Toyama, Toyama, Japan

    Satoshi Kuroda

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Suda, S. (2017). Bone Marrow-Derived Mononuclear Cells. In: Houkin, K., Abe, K., Kuroda, S. (eds) Cell Therapy Against Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56059-3_1

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