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Alterations of BMP signaling pathway(s) in skeletal diseases

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Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The existence of bone morphogenetic proteins (BMPs) was postulated by Urist already in 1965 based on the observation that dematerialized bone matrix is able to induce bone formation when transplanted into the muscle of rabbits or rats [1]. Because heat-denatured samples did not show this effect, he concluded that the inducing substance had to be a protein and suggested the name ‚bone morphogenetic protein’. It took 20 more years after that pioneering observation to actually prove this theory. The first report on purification of a BMP was in 1988 by Elizabeth Wang and colleagues [2] and soon thereafter a series of ground-breaking discoveries followed. BMPs were either purified or cloned from cartilage and/or bone [3–9]. It turned out that the different BMPs are quite homologous to each other and structurally related to TGF-β proteins [6, 10, 11]. Due to their similarities they were classified as the TGF-β superfamily with a large subgroup of proteins named BMPs and growth and differentiation factors (GDFs). With a few exceptions, BMPs and GDFs are capable of inducing ectopic bone and or cartilage formation in vitro and in vivo.

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Authors and Affiliations

  1. Max-Planck-Institut für Molekulare Genetik, Research Group Development & Disease, Ihnestr. 63-73, 14195, Berlin, Germany

    Petra Seemann & Stefan Mundlos

  2. Institut für Medizinische Genetik, Universitätsmedizin Berlin, Charité, Augustenburger Platz 1, 13353, Berlin, Germany

    Stefan Mundlos & Katarina Lehmann

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  1. Petra Seemann
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  1. School of Medicine Inst. Anatomy Drago Perovic, University of Zagreb, Salata 11, 10000, Zagreb, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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Seemann, P., Mundlos, S., Lehmann, K. (2008). Alterations of BMP signaling pathway(s) in skeletal diseases. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8552-1_8

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  • DOI: https://doi.org/10.1007/978-3-7643-8552-1_8

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